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Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids.
Talanta. 2005 Oct 15; 67(4):703-12.T

Abstract

The voltammetric behavior of cefixime was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefixime was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. Different parameters were tested to optimize the conditions for the determination of cefixime. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was investigated. According to the linear relationship between the peak current and the concentration, differential pulse (DPV) and square wave (SWV) voltammetric methods for cefixime assay in pharmaceutical dosage forms and biological fluids were developed. For the determination of cefixime were proposed in acetate buffer at pH 4.5, which allows quantitation over the 6 x 10(-6)-2 x 10(-4)M range in supporting electrolyte and spiked serum sample; 8 x 10(-6)-2 x 10(-4)M range in urine sample; 6 x 10(-6)-1 x 10(-4)M range in breast milk samples for both techniques. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and in the biological samples, respectively.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science and Arts, Kahramanmaras Sutcu Imam University, Campus of Avsar, Kahramanmaras, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18970228

Citation

Golcu, Ayşegul, et al. "Anodic Voltammetric Behavior and Determination of Cefixime in Pharmaceutical Dosage Forms and Biological Fluids." Talanta, vol. 67, no. 4, 2005, pp. 703-12.
Golcu A, Dogan B, Ozkan SA. Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids. Talanta. 2005;67(4):703-12.
Golcu, A., Dogan, B., & Ozkan, S. A. (2005). Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids. Talanta, 67(4), 703-12. https://doi.org/10.1016/j.talanta.2005.03.020
Golcu A, Dogan B, Ozkan SA. Anodic Voltammetric Behavior and Determination of Cefixime in Pharmaceutical Dosage Forms and Biological Fluids. Talanta. 2005 Oct 15;67(4):703-12. PubMed PMID: 18970228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids. AU - Golcu,Ayşegul, AU - Dogan,Burcu, AU - Ozkan,Sibel A, Y1 - 2005/04/25/ PY - 2004/12/08/received PY - 2005/03/03/revised PY - 2005/03/18/accepted PY - 2008/10/31/pubmed PY - 2008/10/31/medline PY - 2008/10/31/entrez SP - 703 EP - 12 JF - Talanta JO - Talanta VL - 67 IS - 4 N2 - The voltammetric behavior of cefixime was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefixime was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. Different parameters were tested to optimize the conditions for the determination of cefixime. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was investigated. According to the linear relationship between the peak current and the concentration, differential pulse (DPV) and square wave (SWV) voltammetric methods for cefixime assay in pharmaceutical dosage forms and biological fluids were developed. For the determination of cefixime were proposed in acetate buffer at pH 4.5, which allows quantitation over the 6 x 10(-6)-2 x 10(-4)M range in supporting electrolyte and spiked serum sample; 8 x 10(-6)-2 x 10(-4)M range in urine sample; 6 x 10(-6)-1 x 10(-4)M range in breast milk samples for both techniques. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and in the biological samples, respectively. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/18970228/Anodic_voltammetric_behavior_and_determination_of_cefixime_in_pharmaceutical_dosage_forms_and_biological_fluids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(05)00177-3 DB - PRIME DP - Unbound Medicine ER -
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