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[Intolerance to food additives: an update].
Minerva Pediatr 2008; 60(6):1401-9MP

Abstract

Contrary to common believing, the prevalence of the intolerance to food additives in the general population is rather low. Nowadays many doubts persist with regard both to the pathogenetic mechanisms and to the clinical and diagnostic aspects in this field. Symptoms due to, or exacerbated from, food additives usually involve non-IgE-mediate mechanisms (pseudo-allergic reactions, PAR) and are usually less severe of those induced by food allergy. The most frequent clinical feature of the intolerance to food additives still remains the urticaria-angioedema syndrome, although these substances are really involved only in a minority of patients. Other possible clinical features include anaphylaxis, atopic eczema, behaviour disturbances, asthma and non-allergic rhinitis. The diagnostic approach consists in diary cards, reporting symptoms and food habits, elimination diet and double blinded placebo-controlled oral challenge with suspected additives. However, such procedure still remains poorly standardized and numerous uncertainties persist with regard to optimal conditions for performing and interpret the challenge results. The therapeutic approach consists in the exclusion of foods and products containing the additive involved, and, in patients not compliant to the diet, in treatment with symptomatic drugs.

Authors+Show Affiliations

Clinica Pediatrica 1, Dipartimento di Biomedicina dell'Età Evolutiva, Università di Bari, Bari, Italia. fabiocardinale@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

ita

PubMed ID

18971901

Citation

Cardinale, F, et al. "[Intolerance to Food Additives: an Update]." Minerva Pediatrica, vol. 60, no. 6, 2008, pp. 1401-9.
Cardinale F, Mangini F, Berardi M, et al. [Intolerance to food additives: an update]. Minerva Pediatr. 2008;60(6):1401-9.
Cardinale, F., Mangini, F., Berardi, M., Sterpeta Loffredo, M., Chinellato, I., Dellino, A., ... Armenio, L. (2008). [Intolerance to food additives: an update]. Minerva Pediatrica, 60(6), pp. 1401-9.
Cardinale F, et al. [Intolerance to Food Additives: an Update]. Minerva Pediatr. 2008;60(6):1401-9. PubMed PMID: 18971901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intolerance to food additives: an update]. AU - Cardinale,F, AU - Mangini,F, AU - Berardi,M, AU - Sterpeta Loffredo,M, AU - Chinellato,I, AU - Dellino,A, AU - Cristofori,F, AU - Di Domenico,F, AU - Mastrototaro,M F, AU - Cappiello,A, AU - Centoducati,T, AU - Carella,F, AU - Armenio,L, PY - 2008/10/31/pubmed PY - 2009/2/3/medline PY - 2008/10/31/entrez SP - 1401 EP - 9 JF - Minerva pediatrica JO - Minerva Pediatr. VL - 60 IS - 6 N2 - Contrary to common believing, the prevalence of the intolerance to food additives in the general population is rather low. Nowadays many doubts persist with regard both to the pathogenetic mechanisms and to the clinical and diagnostic aspects in this field. Symptoms due to, or exacerbated from, food additives usually involve non-IgE-mediate mechanisms (pseudo-allergic reactions, PAR) and are usually less severe of those induced by food allergy. The most frequent clinical feature of the intolerance to food additives still remains the urticaria-angioedema syndrome, although these substances are really involved only in a minority of patients. Other possible clinical features include anaphylaxis, atopic eczema, behaviour disturbances, asthma and non-allergic rhinitis. The diagnostic approach consists in diary cards, reporting symptoms and food habits, elimination diet and double blinded placebo-controlled oral challenge with suspected additives. However, such procedure still remains poorly standardized and numerous uncertainties persist with regard to optimal conditions for performing and interpret the challenge results. The therapeutic approach consists in the exclusion of foods and products containing the additive involved, and, in patients not compliant to the diet, in treatment with symptomatic drugs. SN - 0026-4946 UR - https://www.unboundmedicine.com/medline/citation/18971901/[Intolerance_to_food_additives:_an_update]_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -