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The aminothiol redox status in haemodialysis patients does not improve with folate therapy.
Scand J Clin Lab Invest 2009; 69(2):265-71SJ

Abstract

BACKGROUND

Patients on haemodialysis suffer from high cardiovascular morbidity and mortality, and oxidative stress may play a role in the pathophysiology of cardiovascular disease in these patients. Hyperhomocysteinemia is common in dialysis patients and may have pro-oxidant effects. Moreover, the redox status of the major plasma aminothiols (homocysteine [Hcy], cysteine and cysteinylglycine) may be regarded as a biomarker of oxidative stress. In the present study, we investigated the aminothiol redox status during a period of homocysteine-lowering therapy with folinic acid.

MATERIAL AND METHODS

In the first part of the study, 32 stable patients receiving maintenance haemodialysis were compared with 32 reference subjects. In the second part, the patients were given folinic acid intravenously for 3 months.

RESULTS

Before intervention with folinic acid, the patients had elevated concentrations of all redox species of Hcy. The aminothiol redox ratios were low. Folinic acid therapy lowered the concentrations of all Hcy redox species; however, the redox ratios did not improve.

CONCLUSIONS

The low aminothiol redox ratios indicate the presence of oxidative stress in haemodialysis patients. Therapy with folinic acid lowered total Hcy concentrations, but did not improve the redox status. Thus, hyperhomocysteinemia appears to be of little importance in regard to the total level of oxidative stress in uraemia.

Authors+Show Affiliations

Department of Medicine, Stavanger University Hospital, Stavanger, Norway. apeland@online.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18972259

Citation

Apeland, T, et al. "The Aminothiol Redox Status in Haemodialysis Patients Does Not Improve With Folate Therapy." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 69, no. 2, 2009, pp. 265-71.
Apeland T, Kristensen O, Mansoor MA. The aminothiol redox status in haemodialysis patients does not improve with folate therapy. Scand J Clin Lab Invest. 2009;69(2):265-71.
Apeland, T., Kristensen, O., & Mansoor, M. A. (2009). The aminothiol redox status in haemodialysis patients does not improve with folate therapy. Scandinavian Journal of Clinical and Laboratory Investigation, 69(2), pp. 265-71. doi:10.1080/00365510802521143.
Apeland T, Kristensen O, Mansoor MA. The Aminothiol Redox Status in Haemodialysis Patients Does Not Improve With Folate Therapy. Scand J Clin Lab Invest. 2009;69(2):265-71. PubMed PMID: 18972259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The aminothiol redox status in haemodialysis patients does not improve with folate therapy. AU - Apeland,T, AU - Kristensen,O, AU - Mansoor,M A, PY - 2008/10/31/pubmed PY - 2009/5/20/medline PY - 2008/10/31/entrez SP - 265 EP - 71 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 69 IS - 2 N2 - BACKGROUND: Patients on haemodialysis suffer from high cardiovascular morbidity and mortality, and oxidative stress may play a role in the pathophysiology of cardiovascular disease in these patients. Hyperhomocysteinemia is common in dialysis patients and may have pro-oxidant effects. Moreover, the redox status of the major plasma aminothiols (homocysteine [Hcy], cysteine and cysteinylglycine) may be regarded as a biomarker of oxidative stress. In the present study, we investigated the aminothiol redox status during a period of homocysteine-lowering therapy with folinic acid. MATERIAL AND METHODS: In the first part of the study, 32 stable patients receiving maintenance haemodialysis were compared with 32 reference subjects. In the second part, the patients were given folinic acid intravenously for 3 months. RESULTS: Before intervention with folinic acid, the patients had elevated concentrations of all redox species of Hcy. The aminothiol redox ratios were low. Folinic acid therapy lowered the concentrations of all Hcy redox species; however, the redox ratios did not improve. CONCLUSIONS: The low aminothiol redox ratios indicate the presence of oxidative stress in haemodialysis patients. Therapy with folinic acid lowered total Hcy concentrations, but did not improve the redox status. Thus, hyperhomocysteinemia appears to be of little importance in regard to the total level of oxidative stress in uraemia. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/18972259/The_aminothiol_redox_status_in_haemodialysis_patients_does_not_improve_with_folate_therapy_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510802521143 DB - PRIME DP - Unbound Medicine ER -