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Squamous cell carcinoma of the buccal mucosa in a young adult with history of allogeneic bone marrow transplantation for childhood acute leukemia.
Head Neck. 2009 Apr; 31(4):565-8.HN

Abstract

BACKGROUND

Secondary cancers are severe complications in patients who have had allogeneic bone marrow transplantation for childhood leukemia. We describe here a case of squamous cell carcinoma (SCC) of the buccal mucosa in a young adult patient who had had allogeneic bone marrow transplantation for childhood acute leukemia.

METHODS AND RESULTS

The primary tumor was treated with interstitial brachytherapy, and lymph node metastasis was treated by supraomohyoid neck dissection. The patient had a history of acute lymphoblastic leukemia (ALL) at 11 years of age and had received an allogeneic bone marrow transplant from a female donor. Further investigation of the tissue specimens by fluorescent in situ hybridization (FISH) revealed that an XX chromosome pattern was dominant in the tumor region, and this suggested that donor-derived cells might affect carcinogenesis in the recipient.

CONCLUSIONS

This case presents an incidence of secondary oral cancer associated with allogeneic bone marrow transplantation.

Authors+Show Affiliations

Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan. tokei@sapmed.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18972418

Citation

Tomihara, Kei, et al. "Squamous Cell Carcinoma of the Buccal Mucosa in a Young Adult With History of Allogeneic Bone Marrow Transplantation for Childhood Acute Leukemia." Head & Neck, vol. 31, no. 4, 2009, pp. 565-8.
Tomihara K, Dehari H, Yamaguchi A, et al. Squamous cell carcinoma of the buccal mucosa in a young adult with history of allogeneic bone marrow transplantation for childhood acute leukemia. Head Neck. 2009;31(4):565-8.
Tomihara, K., Dehari, H., Yamaguchi, A., Abe, M., Miyazaki, A., Nakamori, K., Hareyama, M., & Hiratsuka, H. (2009). Squamous cell carcinoma of the buccal mucosa in a young adult with history of allogeneic bone marrow transplantation for childhood acute leukemia. Head & Neck, 31(4), 565-8. https://doi.org/10.1002/hed.20931
Tomihara K, et al. Squamous Cell Carcinoma of the Buccal Mucosa in a Young Adult With History of Allogeneic Bone Marrow Transplantation for Childhood Acute Leukemia. Head Neck. 2009;31(4):565-8. PubMed PMID: 18972418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Squamous cell carcinoma of the buccal mucosa in a young adult with history of allogeneic bone marrow transplantation for childhood acute leukemia. AU - Tomihara,Kei, AU - Dehari,Hironari, AU - Yamaguchi,Akira, AU - Abe,Masato, AU - Miyazaki,Akihiro, AU - Nakamori,Kenji, AU - Hareyama,Masato, AU - Hiratsuka,Hiroyoshi, PY - 2008/10/31/pubmed PY - 2009/7/22/medline PY - 2008/10/31/entrez SP - 565 EP - 8 JF - Head & neck JO - Head Neck VL - 31 IS - 4 N2 - BACKGROUND: Secondary cancers are severe complications in patients who have had allogeneic bone marrow transplantation for childhood leukemia. We describe here a case of squamous cell carcinoma (SCC) of the buccal mucosa in a young adult patient who had had allogeneic bone marrow transplantation for childhood acute leukemia. METHODS AND RESULTS: The primary tumor was treated with interstitial brachytherapy, and lymph node metastasis was treated by supraomohyoid neck dissection. The patient had a history of acute lymphoblastic leukemia (ALL) at 11 years of age and had received an allogeneic bone marrow transplant from a female donor. Further investigation of the tissue specimens by fluorescent in situ hybridization (FISH) revealed that an XX chromosome pattern was dominant in the tumor region, and this suggested that donor-derived cells might affect carcinogenesis in the recipient. CONCLUSIONS: This case presents an incidence of secondary oral cancer associated with allogeneic bone marrow transplantation. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/18972418/Squamous_cell_carcinoma_of_the_buccal_mucosa_in_a_young_adult_with_history_of_allogeneic_bone_marrow_transplantation_for_childhood_acute_leukemia_ L2 - https://doi.org/10.1002/hed.20931 DB - PRIME DP - Unbound Medicine ER -