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Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent.
J Pharm Sci. 2009 Jul; 98(7):2422-31.JP

Abstract

Solid dispersions of a poorly water-soluble drug piroxicam in polyvinylpyrrolidone (PVP) were prepared by precipitation with compressed antisolvent (PCA) and spray drying techniques. Physicochemical properties of the products and drug-polymer interactions were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, etc. Piroxicam was found amorphously dispersed in both solid dispersion systems with the drug to polymer weight ratio of 1:4. Spectra data indicated the formation of hydrogen bonding between the drug and the polymer. Both techniques evaluated in this work resulted in improved dissolution of piroxicam. By comparison, PCA-processed solid dispersions showed distinctly superior performance in that piroxicam dissolved completely within the first 5 min and the dissolution rate was at least 20 times faster than raw drug did within the first 15 min. PCA processing could provide an effective pharmaceutical formulation technology to improve the bioavailability of poorly water-soluble drug.

Authors+Show Affiliations

Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18972575

Citation

Wu, Ke, et al. "Formation and Characterization of Solid Dispersions of Piroxicam and Polyvinylpyrrolidone Using Spray Drying and Precipitation With Compressed Antisolvent." Journal of Pharmaceutical Sciences, vol. 98, no. 7, 2009, pp. 2422-31.
Wu K, Li J, Wang W, et al. Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent. J Pharm Sci. 2009;98(7):2422-31.
Wu, K., Li, J., Wang, W., & Winstead, D. A. (2009). Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent. Journal of Pharmaceutical Sciences, 98(7), 2422-31. https://doi.org/10.1002/jps.21598
Wu K, et al. Formation and Characterization of Solid Dispersions of Piroxicam and Polyvinylpyrrolidone Using Spray Drying and Precipitation With Compressed Antisolvent. J Pharm Sci. 2009;98(7):2422-31. PubMed PMID: 18972575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent. AU - Wu,Ke, AU - Li,Jing, AU - Wang,Wayne, AU - Winstead,Denita A, PY - 2008/10/31/pubmed PY - 2009/8/20/medline PY - 2008/10/31/entrez SP - 2422 EP - 31 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 98 IS - 7 N2 - Solid dispersions of a poorly water-soluble drug piroxicam in polyvinylpyrrolidone (PVP) were prepared by precipitation with compressed antisolvent (PCA) and spray drying techniques. Physicochemical properties of the products and drug-polymer interactions were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, etc. Piroxicam was found amorphously dispersed in both solid dispersion systems with the drug to polymer weight ratio of 1:4. Spectra data indicated the formation of hydrogen bonding between the drug and the polymer. Both techniques evaluated in this work resulted in improved dissolution of piroxicam. By comparison, PCA-processed solid dispersions showed distinctly superior performance in that piroxicam dissolved completely within the first 5 min and the dissolution rate was at least 20 times faster than raw drug did within the first 15 min. PCA processing could provide an effective pharmaceutical formulation technology to improve the bioavailability of poorly water-soluble drug. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/18972575/Formation_and_characterization_of_solid_dispersions_of_piroxicam_and_polyvinylpyrrolidone_using_spray_drying_and_precipitation_with_compressed_antisolvent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(16)33007-6 DB - PRIME DP - Unbound Medicine ER -