Tags

Type your tag names separated by a space and hit enter

[The antioxidative effect of Sanwei Tanxiang powder on rats' hearts against myocardial ischemia and reperfusion injury].
Zhong Yao Cai. 2008 Jul; 31(7):1013-5.ZY

Abstract

OBJECTIVE

To study the effect of Sanwei Tanxiang powder on myocardial pathologic change, myocardium lipid peroxidation and antioxidation on anesthetized rats' hearts against myocardial ischemia and reperfusion injury.

METHODS

A model of regional myocardial ischemia-reperfusion injury (IR) was established by 30 min ligation of the left anterior descending coronary artery followed by 40 min reperfusion in hearts of anesthetized rats'. The experimental animals were randomly divided into the sham operation, IR model group, positive control group and two dose Sanwei Tanxiang powder groups. The changes of ECG, LDH, CK, SOD, GSH-Px and MDA in the heart were measured and ultrastructural pathological changes were observed.

RESULTS

In Sanwei Tanxiang groups the displacement of ST segment reduced (P < 0.05), the activity of LDH, CK decreased (P < 0.05), the activities of SOD, GSH-Px significantly increased and the contents of MDA reduced (P < 0.05). Moreover, the development of ultrastructral pathological changes obviously improved compared with the IR model group.

CONCLUSION

The protective effects of Sanwei Tanxiang powder on anesthetized rats' hearts against myocardial ischemia and reperfusion injury may be related to protecting the antioxidants and inhibiting the lipid peroxidation in the myocardium.

Authors+Show Affiliations

Kou YY
Medical College Qinghai University, Xining 810001, China. kouyiying2000@yahoo.com.cn
Zha XD
No affiliation info available
Li YF
No affiliation info available
Ge RL
No affiliation info available

MeSH

AnimalsAntioxidantsCreatine KinaseDisease Models, AnimalDrug CombinationsDrugs, Chinese HerbalElectrocardiographyFemaleL-Lactate DehydrogenaseMaleMalondialdehydeMyocardial IschemiaMyocardial Reperfusion InjuryMyocardiumPlants, MedicinalRandom AllocationRatsRats, Sprague-DawleySantalumSuperoxide Dismutase

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18973018

Citation

Kou, Yi-Ying, et al. "[The Antioxidative Effect of Sanwei Tanxiang Powder On Rats' Hearts Against Myocardial Ischemia and Reperfusion Injury]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 31, no. 7, 2008, pp. 1013-5.
Kou YY, Zha XD, Li YF, et al. [The antioxidative effect of Sanwei Tanxiang powder on rats' hearts against myocardial ischemia and reperfusion injury]. Zhong Yao Cai. 2008;31(7):1013-5.
Kou, Y. Y., Zha, X. D., Li, Y. F., & Ge, R. L. (2008). [The antioxidative effect of Sanwei Tanxiang powder on rats' hearts against myocardial ischemia and reperfusion injury]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 31(7), 1013-5.
Kou YY, et al. [The Antioxidative Effect of Sanwei Tanxiang Powder On Rats' Hearts Against Myocardial Ischemia and Reperfusion Injury]. Zhong Yao Cai. 2008;31(7):1013-5. PubMed PMID: 18973018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The antioxidative effect of Sanwei Tanxiang powder on rats' hearts against myocardial ischemia and reperfusion injury]. AU - Kou,Yi-Ying, AU - Zha,Xi-Duojie, AU - Li,Yong-Fang, AU - Ge,Ri-Li, PY - 2008/11/1/pubmed PY - 2009/11/10/medline PY - 2008/11/1/entrez SP - 1013 EP - 5 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 31 IS - 7 N2 - OBJECTIVE: To study the effect of Sanwei Tanxiang powder on myocardial pathologic change, myocardium lipid peroxidation and antioxidation on anesthetized rats' hearts against myocardial ischemia and reperfusion injury. METHODS: A model of regional myocardial ischemia-reperfusion injury (IR) was established by 30 min ligation of the left anterior descending coronary artery followed by 40 min reperfusion in hearts of anesthetized rats'. The experimental animals were randomly divided into the sham operation, IR model group, positive control group and two dose Sanwei Tanxiang powder groups. The changes of ECG, LDH, CK, SOD, GSH-Px and MDA in the heart were measured and ultrastructural pathological changes were observed. RESULTS: In Sanwei Tanxiang groups the displacement of ST segment reduced (P < 0.05), the activity of LDH, CK decreased (P < 0.05), the activities of SOD, GSH-Px significantly increased and the contents of MDA reduced (P < 0.05). Moreover, the development of ultrastructral pathological changes obviously improved compared with the IR model group. CONCLUSION: The protective effects of Sanwei Tanxiang powder on anesthetized rats' hearts against myocardial ischemia and reperfusion injury may be related to protecting the antioxidants and inhibiting the lipid peroxidation in the myocardium. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/18973018/[The_antioxidative_effect_of_Sanwei_Tanxiang_powder_on_rats'_hearts_against_myocardial_ischemia_and_reperfusion_injury]_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -