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Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis.
J Periodontal Res. 2009 Aug; 44(4):452-8.JP

Abstract

BACKGROUND AND OBJECTIVE

An association has been found between periodontal disease and the development of atherosclerosis. We investigated the hypothesis that periodontal disease triggers the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in blood. Increased levels of these parameters might then indicate early atherosclerosis.

MATERIAL AND METHODS

In this cross-sectional study, the material comprised 80 subjects with chronic periodontitis and 31 subjects with no periodontal disease. Sixteen years after diagnosis of periodontal disease ultrasonography revealed a statistically significant difference (p < 0.001) of carotid intima-media thickness between the subjects with chronic periodontitis and the periodontally healthy subjects. Matrix metalloproteinase-9 and TIMP-1 were analyzed from blood as periodontal and systemic inflammatory markers. The relationship between MMP-9, TIMP-1 and MMP-9/TIMP-1 as dependent variables and several independent variables (age, sex, smoking, education, body mass index, hypertension, periodontal disease and cholesterol) were analyzed in multiple logistic regression models to assess the value of the inflammatory markers in predicting carotid atherosclerosis.

RESULTS

Matrix metalloproteinase-9 and TIMP-1 were significantly higher in plasma from subjects with periodontal disease and atherosclerosis. Periodontal disease was identified as the principal independent predictor both for atherosclerosis (odds ratio 3.89 for increase in bilateral carotid intima-media thickness) and for increased MMP-9, TIMP-1 and MMP-9/TIMP-1 (odds ratio 2.58, 5.53 and 3.41, respectively). Classical atherosclerosis risk factors, such as increased total cholesterol, age and sex (women), were significant predictors in the model.

CONCLUSION

Matrix metalloproteinase-9, TIMP-1 and MMP-9/TIMP-1 in blood from subjects with periodontal disease could be useful laboratory markers for increased carotid artery intima-media thickness.

Authors+Show Affiliations

Institute of Odontology, Karolinska Institute, Huddinge, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18973519

Citation

Söder, P-O, et al. "Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Blood as Markers for Early Atherosclerosis in Subjects With Chronic Periodontitis." Journal of Periodontal Research, vol. 44, no. 4, 2009, pp. 452-8.
Söder PO, Meurman JH, Jogestrand T, et al. Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. J Periodont Res. 2009;44(4):452-8.
Söder, P. O., Meurman, J. H., Jogestrand, T., Nowak, J., & Söder, B. (2009). Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. Journal of Periodontal Research, 44(4), 452-8. https://doi.org/10.1111/j.1600-0765.2008.01145.x
Söder PO, et al. Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Blood as Markers for Early Atherosclerosis in Subjects With Chronic Periodontitis. J Periodont Res. 2009;44(4):452-8. PubMed PMID: 18973519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. AU - Söder,P-O, AU - Meurman,J H, AU - Jogestrand,T, AU - Nowak,J, AU - Söder,B, Y1 - 2008/10/22/ PY - 2008/11/1/pubmed PY - 2009/10/30/medline PY - 2008/11/1/entrez SP - 452 EP - 8 JF - Journal of periodontal research JO - J. Periodont. Res. VL - 44 IS - 4 N2 - BACKGROUND AND OBJECTIVE: An association has been found between periodontal disease and the development of atherosclerosis. We investigated the hypothesis that periodontal disease triggers the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in blood. Increased levels of these parameters might then indicate early atherosclerosis. MATERIAL AND METHODS: In this cross-sectional study, the material comprised 80 subjects with chronic periodontitis and 31 subjects with no periodontal disease. Sixteen years after diagnosis of periodontal disease ultrasonography revealed a statistically significant difference (p < 0.001) of carotid intima-media thickness between the subjects with chronic periodontitis and the periodontally healthy subjects. Matrix metalloproteinase-9 and TIMP-1 were analyzed from blood as periodontal and systemic inflammatory markers. The relationship between MMP-9, TIMP-1 and MMP-9/TIMP-1 as dependent variables and several independent variables (age, sex, smoking, education, body mass index, hypertension, periodontal disease and cholesterol) were analyzed in multiple logistic regression models to assess the value of the inflammatory markers in predicting carotid atherosclerosis. RESULTS: Matrix metalloproteinase-9 and TIMP-1 were significantly higher in plasma from subjects with periodontal disease and atherosclerosis. Periodontal disease was identified as the principal independent predictor both for atherosclerosis (odds ratio 3.89 for increase in bilateral carotid intima-media thickness) and for increased MMP-9, TIMP-1 and MMP-9/TIMP-1 (odds ratio 2.58, 5.53 and 3.41, respectively). Classical atherosclerosis risk factors, such as increased total cholesterol, age and sex (women), were significant predictors in the model. CONCLUSION: Matrix metalloproteinase-9, TIMP-1 and MMP-9/TIMP-1 in blood from subjects with periodontal disease could be useful laboratory markers for increased carotid artery intima-media thickness. SN - 1600-0765 UR - https://www.unboundmedicine.com/medline/citation/18973519/Matrix_metalloproteinase_9_and_tissue_inhibitor_of_matrix_metalloproteinase_1_in_blood_as_markers_for_early_atherosclerosis_in_subjects_with_chronic_periodontitis_ L2 - https://doi.org/10.1111/j.1600-0765.2008.01145.x DB - PRIME DP - Unbound Medicine ER -