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Acute and sensitized response to 3,4-methylenedioxymethamphetamine in rats: different behavioral profiles reflected in different patterns of Fos expression.
Eur J Neurosci. 2008 Nov; 28(9):1895-910.EJ

Abstract

The behavioral profile in response to (+/-)-3,4-methylenedioxymethamphetamine (MDMA) is characterized by acute hyperlocomotion that is primarily restricted to the periphery of the open field, whereas behavioral sensitization to MDMA reflects a selective increase in activity in the central zone, suggesting that acute effects and sensitization might rely on neuroadaptations in different systems. This study was thus undertaken to determine whether specific changes in neuronal activation could be correlated with either the acute or sensitized behavioral responses to MDMA. Animals received five daily intraperitoneal (i.p.) injections of saline or MDMA (10 mg/kg). Two days later, animals that received saline were injected with saline or MDMA (5 or 10 mg/kg, i.p.). Animals pretreated with MDMA were injected with saline or MDMA (5 mg/kg, i.p.). Locomotor activity was measured in an open field, and neuronal activation was examined by immunodetection of Fos. Acute MDMA exposure produced a dose-dependent increase in locomotion in the peripheral zone of the open field that was related to an increase in Fos expression in the ventromedial shell of the nucleus accumbens, ventral pallidum, several hypothalamic nuclei and rhomboid thalamic nucleus. Following repeated, intermittent exposure to MDMA, drug-produced hyperactivity became sensitized but, unlike the effect of increasing dose, the increased response was due to increased activity and time spent in the central zone. Furthermore, the sensitized behavioral response was related to changes in Fos expression in the lateral shell of the nucleus accumbens, central nucleus of the amygdala and anteromedial part of the lateral habenula. This study identifies neural substrates that might specifically underlie the sensitized response to MDMA.

Authors+Show Affiliations

School of Psychology, Victoria University of Wellington, Wellington, PO Box 600, New Zealand.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18973603

Citation

Colussi-Mas, Joyce, and Susan Schenk. "Acute and Sensitized Response to 3,4-methylenedioxymethamphetamine in Rats: Different Behavioral Profiles Reflected in Different Patterns of Fos Expression." The European Journal of Neuroscience, vol. 28, no. 9, 2008, pp. 1895-910.
Colussi-Mas J, Schenk S. Acute and sensitized response to 3,4-methylenedioxymethamphetamine in rats: different behavioral profiles reflected in different patterns of Fos expression. Eur J Neurosci. 2008;28(9):1895-910.
Colussi-Mas, J., & Schenk, S. (2008). Acute and sensitized response to 3,4-methylenedioxymethamphetamine in rats: different behavioral profiles reflected in different patterns of Fos expression. The European Journal of Neuroscience, 28(9), 1895-910. https://doi.org/10.1111/j.1460-9568.2008.06467.x
Colussi-Mas J, Schenk S. Acute and Sensitized Response to 3,4-methylenedioxymethamphetamine in Rats: Different Behavioral Profiles Reflected in Different Patterns of Fos Expression. Eur J Neurosci. 2008;28(9):1895-910. PubMed PMID: 18973603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute and sensitized response to 3,4-methylenedioxymethamphetamine in rats: different behavioral profiles reflected in different patterns of Fos expression. AU - Colussi-Mas,Joyce, AU - Schenk,Susan, PY - 2008/11/1/pubmed PY - 2009/1/22/medline PY - 2008/11/1/entrez SP - 1895 EP - 910 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 28 IS - 9 N2 - The behavioral profile in response to (+/-)-3,4-methylenedioxymethamphetamine (MDMA) is characterized by acute hyperlocomotion that is primarily restricted to the periphery of the open field, whereas behavioral sensitization to MDMA reflects a selective increase in activity in the central zone, suggesting that acute effects and sensitization might rely on neuroadaptations in different systems. This study was thus undertaken to determine whether specific changes in neuronal activation could be correlated with either the acute or sensitized behavioral responses to MDMA. Animals received five daily intraperitoneal (i.p.) injections of saline or MDMA (10 mg/kg). Two days later, animals that received saline were injected with saline or MDMA (5 or 10 mg/kg, i.p.). Animals pretreated with MDMA were injected with saline or MDMA (5 mg/kg, i.p.). Locomotor activity was measured in an open field, and neuronal activation was examined by immunodetection of Fos. Acute MDMA exposure produced a dose-dependent increase in locomotion in the peripheral zone of the open field that was related to an increase in Fos expression in the ventromedial shell of the nucleus accumbens, ventral pallidum, several hypothalamic nuclei and rhomboid thalamic nucleus. Following repeated, intermittent exposure to MDMA, drug-produced hyperactivity became sensitized but, unlike the effect of increasing dose, the increased response was due to increased activity and time spent in the central zone. Furthermore, the sensitized behavioral response was related to changes in Fos expression in the lateral shell of the nucleus accumbens, central nucleus of the amygdala and anteromedial part of the lateral habenula. This study identifies neural substrates that might specifically underlie the sensitized response to MDMA. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/18973603/Acute_and_sensitized_response_to_34_methylenedioxymethamphetamine_in_rats:_different_behavioral_profiles_reflected_in_different_patterns_of_Fos_expression_ L2 - https://doi.org/10.1111/j.1460-9568.2008.06467.x DB - PRIME DP - Unbound Medicine ER -