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Pediatric obesity: an inflammatory condition?
JPEN J Parenter Enteral Nutr 2008 Nov-Dec; 32(6):633-7JJ

Abstract

Childhood obesity has grown at an alarming rate, and concomitant with this rise there is an increasing prevalence of metabolic risk factors in young children and adolescents. These metabolic risk factors include elevated circulating triglycerides and low levels of high-density lipoprotein, but also an increase in inflammatory biomarkers such as C-reactive protein and interleukin-6. Each of these factors has been associated with the development of chronic diseases such as type 2 diabetes and cardiovascular disease. Recent research has indicated that dietary modifications such as increased intakes of antioxidants or omega-3 fatty acids or increased physical activity and physical fitness may independently modify the inflammation associated with excess adiposity. Additional research on the impact of diet and exercise on inflammation in children is warranted, especially studies that are prospective in nature. Finally, current biomarkers of inflammation may not be sensitive enough to detect metabolic risk in youth, and novel biomarkers may be needed to detect the subtle changes in inflammation due to diet and physical activity modifications.

Authors+Show Affiliations

John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA. jennifer.sacheck@tufts.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18974243

Citation

Sacheck, Jennifer. "Pediatric Obesity: an Inflammatory Condition?" JPEN. Journal of Parenteral and Enteral Nutrition, vol. 32, no. 6, 2008, pp. 633-7.
Sacheck J. Pediatric obesity: an inflammatory condition? JPEN J Parenter Enteral Nutr. 2008;32(6):633-7.
Sacheck, J. (2008). Pediatric obesity: an inflammatory condition? JPEN. Journal of Parenteral and Enteral Nutrition, 32(6), pp. 633-7. doi:10.1177/0148607108324876.
Sacheck J. Pediatric Obesity: an Inflammatory Condition. JPEN J Parenter Enteral Nutr. 2008;32(6):633-7. PubMed PMID: 18974243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric obesity: an inflammatory condition? A1 - Sacheck,Jennifer, PY - 2008/11/1/pubmed PY - 2009/2/6/medline PY - 2008/11/1/entrez SP - 633 EP - 7 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 32 IS - 6 N2 - Childhood obesity has grown at an alarming rate, and concomitant with this rise there is an increasing prevalence of metabolic risk factors in young children and adolescents. These metabolic risk factors include elevated circulating triglycerides and low levels of high-density lipoprotein, but also an increase in inflammatory biomarkers such as C-reactive protein and interleukin-6. Each of these factors has been associated with the development of chronic diseases such as type 2 diabetes and cardiovascular disease. Recent research has indicated that dietary modifications such as increased intakes of antioxidants or omega-3 fatty acids or increased physical activity and physical fitness may independently modify the inflammation associated with excess adiposity. Additional research on the impact of diet and exercise on inflammation in children is warranted, especially studies that are prospective in nature. Finally, current biomarkers of inflammation may not be sensitive enough to detect metabolic risk in youth, and novel biomarkers may be needed to detect the subtle changes in inflammation due to diet and physical activity modifications. SN - 0148-6071 UR - https://www.unboundmedicine.com/medline/citation/18974243/Pediatric_obesity:_an_inflammatory_condition L2 - https://doi.org/10.1177/0148607108324876 DB - PRIME DP - Unbound Medicine ER -