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Pediatric obesity: an inflammatory condition?

Abstract

Childhood obesity has grown at an alarming rate, and concomitant with this rise there is an increasing prevalence of metabolic risk factors in young children and adolescents. These metabolic risk factors include elevated circulating triglycerides and low levels of high-density lipoprotein, but also an increase in inflammatory biomarkers such as C-reactive protein and interleukin-6. Each of these factors has been associated with the development of chronic diseases such as type 2 diabetes and cardiovascular disease. Recent research has indicated that dietary modifications such as increased intakes of antioxidants or omega-3 fatty acids or increased physical activity and physical fitness may independently modify the inflammation associated with excess adiposity. Additional research on the impact of diet and exercise on inflammation in children is warranted, especially studies that are prospective in nature. Finally, current biomarkers of inflammation may not be sensitive enough to detect metabolic risk in youth, and novel biomarkers may be needed to detect the subtle changes in inflammation due to diet and physical activity modifications.

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  • Publisher Full Text
  • Authors+Show Affiliations

    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA. jennifer.sacheck@tufts.edu

    Source

    MeSH

    Adolescent
    Biomarkers
    C-Reactive Protein
    Child
    Diet
    Exercise
    Humans
    Inflammation
    Interleukin-6
    Obesity
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18974243

    Citation

    Sacheck, Jennifer. "Pediatric Obesity: an Inflammatory Condition?" JPEN. Journal of Parenteral and Enteral Nutrition, vol. 32, no. 6, 2008, pp. 633-7.
    Sacheck J. Pediatric obesity: an inflammatory condition? JPEN J Parenter Enteral Nutr. 2008;32(6):633-7.
    Sacheck, J. (2008). Pediatric obesity: an inflammatory condition? JPEN. Journal of Parenteral and Enteral Nutrition, 32(6), pp. 633-7. doi:10.1177/0148607108324876.
    Sacheck J. Pediatric Obesity: an Inflammatory Condition. JPEN J Parenter Enteral Nutr. 2008;32(6):633-7. PubMed PMID: 18974243.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pediatric obesity: an inflammatory condition? A1 - Sacheck,Jennifer, PY - 2008/11/1/pubmed PY - 2009/2/6/medline PY - 2008/11/1/entrez SP - 633 EP - 7 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 32 IS - 6 N2 - Childhood obesity has grown at an alarming rate, and concomitant with this rise there is an increasing prevalence of metabolic risk factors in young children and adolescents. These metabolic risk factors include elevated circulating triglycerides and low levels of high-density lipoprotein, but also an increase in inflammatory biomarkers such as C-reactive protein and interleukin-6. Each of these factors has been associated with the development of chronic diseases such as type 2 diabetes and cardiovascular disease. Recent research has indicated that dietary modifications such as increased intakes of antioxidants or omega-3 fatty acids or increased physical activity and physical fitness may independently modify the inflammation associated with excess adiposity. Additional research on the impact of diet and exercise on inflammation in children is warranted, especially studies that are prospective in nature. Finally, current biomarkers of inflammation may not be sensitive enough to detect metabolic risk in youth, and novel biomarkers may be needed to detect the subtle changes in inflammation due to diet and physical activity modifications. SN - 0148-6071 UR - https://www.unboundmedicine.com/medline/citation/18974243/Pediatric_obesity:_an_inflammatory_condition L2 - https://doi.org/10.1177/0148607108324876 DB - PRIME DP - Unbound Medicine ER -