Tags

Type your tag names separated by a space and hit enter

Assessment of the role of nonheme-iron availability in iron balance.
Am J Clin Nutr. 1991 Oct; 54(4):717-22.AJ

Abstract

To assess the nutritional relevance of absorption studies that use extrinsically labeled single meals, we developed a method for measuring nonheme-iron absorption from the diet and compared the results with absorption from single meals. When subjects consumed their usual diet, there was good agreement between dietary absorption (6.4%) and representative single meals fed in the laboratory (6.1%). Nonheme-iron availability, as estimated by a model that incorporated the effect of both enhancers and inhibitors, correlated significantly with absorption from single meals but not with dietary absorption. When the diet was modified to promote iron absorption maximally, dietary absorption increased only slightly (8.0%) and remained significantly lower than it was from single meals (13.5%). With an inhibitory diet, the decrease in absorption from single meals was similarly exaggerated. These results indicate that in the context of a varied Western diet, nonheme-iron bioavailability is less important than absorption studies with single meals would suggest.

Authors+Show Affiliations

Department of Medicine, Kansas University Medical Center, Kansas City 66103.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1897479

Citation

Cook, J D., et al. "Assessment of the Role of Nonheme-iron Availability in Iron Balance." The American Journal of Clinical Nutrition, vol. 54, no. 4, 1991, pp. 717-22.
Cook JD, Dassenko SA, Lynch SR. Assessment of the role of nonheme-iron availability in iron balance. Am J Clin Nutr. 1991;54(4):717-22.
Cook, J. D., Dassenko, S. A., & Lynch, S. R. (1991). Assessment of the role of nonheme-iron availability in iron balance. The American Journal of Clinical Nutrition, 54(4), 717-22.
Cook JD, Dassenko SA, Lynch SR. Assessment of the Role of Nonheme-iron Availability in Iron Balance. Am J Clin Nutr. 1991;54(4):717-22. PubMed PMID: 1897479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the role of nonheme-iron availability in iron balance. AU - Cook,J D, AU - Dassenko,S A, AU - Lynch,S R, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 717 EP - 22 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 54 IS - 4 N2 - To assess the nutritional relevance of absorption studies that use extrinsically labeled single meals, we developed a method for measuring nonheme-iron absorption from the diet and compared the results with absorption from single meals. When subjects consumed their usual diet, there was good agreement between dietary absorption (6.4%) and representative single meals fed in the laboratory (6.1%). Nonheme-iron availability, as estimated by a model that incorporated the effect of both enhancers and inhibitors, correlated significantly with absorption from single meals but not with dietary absorption. When the diet was modified to promote iron absorption maximally, dietary absorption increased only slightly (8.0%) and remained significantly lower than it was from single meals (13.5%). With an inhibitory diet, the decrease in absorption from single meals was similarly exaggerated. These results indicate that in the context of a varied Western diet, nonheme-iron bioavailability is less important than absorption studies with single meals would suggest. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/1897479/Assessment_of_the_role_of_nonheme_iron_availability_in_iron_balance_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/54.4.717 DB - PRIME DP - Unbound Medicine ER -