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Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome.
Fertil Steril. 2009 Oct; 92(4):1372-7.FS

Abstract

OBJECTIVE

To determine whether or not plasma advanced oxidation protein products (AOPPs) are associated with known cardiovascular risk factors or carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS).

DESIGN

A prospective, controlled study.

SETTING

University hospital.

PATIENT(S)

Forty-six women with PCOS and 46 age- and body mass index-matched healthy women.

INTERVENTION(S)

Carotid IMT was evaluated for both common carotid arteries. We measured serum levels of AOPP, homocysteine (Hcy), C-reactive protein (CRP), malonyldialdehyde (MDA), vitamin B(12), folate, lipid, and hormone profiles. The presence of insulin resistance was investigated by means of homeostasis model assessment (HOMA).

MAIN OUTCOME MEASURE(S)

Serum AOPP, fasting insulin, HOMA index, Hcy, MDA, CRP, and carotid IMT.

RESULT(S)

The women with PCOS had significantly higher serum AOPP than control women. High AOPP was defined as equaling or exceeding the mean + 2 SD of the plasma AOPP in control subjects (56.2 pg/mLl). Carotid IMT, fasting insulin, HOMA index, Hcy, MDA, and CRP were significantly higher in PCOS patients with high AOPP than in those with normal AOPP. Fasting insulin, insulin resistance, and Hcy were independent determinants of plasma AOPP.

CONCLUSION(S)

Increased AOPP may contribute to the increased risk of atherosclerotic cardiovascular disease in women with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey. kayacemil000@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18976759

Citation

Kaya, Cemil, et al. "Advanced Oxidation Protein Products Are Increased in Women With Polycystic Ovary Syndrome: Relationship With Traditional and Nontraditional Cardiovascular Risk Factors in Patients With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 92, no. 4, 2009, pp. 1372-7.
Kaya C, Erkan AF, Cengiz SD, et al. Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome. Fertil Steril. 2009;92(4):1372-7.
Kaya, C., Erkan, A. F., Cengiz, S. D., Dünder, I., Demirel, O. E., & Bilgihan, A. (2009). Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome. Fertility and Sterility, 92(4), 1372-7. https://doi.org/10.1016/j.fertnstert.2008.08.016
Kaya C, et al. Advanced Oxidation Protein Products Are Increased in Women With Polycystic Ovary Syndrome: Relationship With Traditional and Nontraditional Cardiovascular Risk Factors in Patients With Polycystic Ovary Syndrome. Fertil Steril. 2009;92(4):1372-7. PubMed PMID: 18976759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome. AU - Kaya,Cemil, AU - Erkan,Aycan Fahri, AU - Cengiz,S Dinçer, AU - Dünder,Ilkkan, AU - Demirel,Ozlem Erbaş, AU - Bilgihan,Ayşe, Y1 - 2008/10/31/ PY - 2008/04/02/received PY - 2008/07/25/revised PY - 2008/08/07/accepted PY - 2008/11/4/pubmed PY - 2009/11/5/medline PY - 2008/11/4/entrez SP - 1372 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 92 IS - 4 N2 - OBJECTIVE: To determine whether or not plasma advanced oxidation protein products (AOPPs) are associated with known cardiovascular risk factors or carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). DESIGN: A prospective, controlled study. SETTING: University hospital. PATIENT(S): Forty-six women with PCOS and 46 age- and body mass index-matched healthy women. INTERVENTION(S): Carotid IMT was evaluated for both common carotid arteries. We measured serum levels of AOPP, homocysteine (Hcy), C-reactive protein (CRP), malonyldialdehyde (MDA), vitamin B(12), folate, lipid, and hormone profiles. The presence of insulin resistance was investigated by means of homeostasis model assessment (HOMA). MAIN OUTCOME MEASURE(S): Serum AOPP, fasting insulin, HOMA index, Hcy, MDA, CRP, and carotid IMT. RESULT(S): The women with PCOS had significantly higher serum AOPP than control women. High AOPP was defined as equaling or exceeding the mean + 2 SD of the plasma AOPP in control subjects (56.2 pg/mLl). Carotid IMT, fasting insulin, HOMA index, Hcy, MDA, and CRP were significantly higher in PCOS patients with high AOPP than in those with normal AOPP. Fasting insulin, insulin resistance, and Hcy were independent determinants of plasma AOPP. CONCLUSION(S): Increased AOPP may contribute to the increased risk of atherosclerotic cardiovascular disease in women with PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18976759/Advanced_oxidation_protein_products_are_increased_in_women_with_polycystic_ovary_syndrome:_relationship_with_traditional_and_nontraditional_cardiovascular_risk_factors_in_patients_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)03362-1 DB - PRIME DP - Unbound Medicine ER -