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Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice.
Nutrition. 2009 Feb; 25(2):233-9.N

Abstract

OBJECTIVE

The aim of this study was to investigate the effects of enteral nutrition (EN) supplemented with glutamine (GLN) on Peyer's patches and intestinal immunoglobulin A (IgA) response in burned mice.

METHODS

Thirty-four mice were randomly assigned to a normal control group (n = 10), an EN group (n = 12), and an EN supplemented with GLN (EN + GLN) group (n = 12) and mice in the EN and EN + GLN groups received a 20% total body surface area, full-thickness scald burn on the back. Then the burned mice were fed with conventional EN or EN + GLN for 7 d. There was isonitrogenous and isocaloric intake in the EN and EN + GLN groups. On day 7 after injury, entire intestines were collected and intestinal IgA levels, total lymphocyte yield, lymphocyte subpopulations, and total apoptotic ratio in Peyer's patches were analyzed.

RESULTS

Total lymphocyte yield, numbers of lymphocyte subpopulations, and intestinal IgA levels in the EN + GLN group were significantly higher than those in the EN group (P < 0.05). The total apoptotic ratio in Peyer's patches was markedly decreased in the EN + GLN group compared with that in the EN group (P < 0.05).

CONCLUSION

The results indicated that EN supplemented with GLN is superior to conventional EN with respect to improvement of intestinal immunity in burned mice.

Authors+Show Affiliations

Department of Burns, The Northern Hospital, Shenyang, Liaoning, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18977117

Citation

Fan, Jun, et al. "Effects of Enteral Nutrition Supplemented With Glutamine On Intestinal Mucosal Immunity in Burned Mice." Nutrition (Burbank, Los Angeles County, Calif.), vol. 25, no. 2, 2009, pp. 233-9.
Fan J, Meng Q, Guo G, et al. Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice. Nutrition. 2009;25(2):233-9.
Fan, J., Meng, Q., Guo, G., Xie, Y., Xiu, Y., Li, T., Feng, W., & Ma, L. (2009). Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice. Nutrition (Burbank, Los Angeles County, Calif.), 25(2), 233-9. https://doi.org/10.1016/j.nut.2008.08.009
Fan J, et al. Effects of Enteral Nutrition Supplemented With Glutamine On Intestinal Mucosal Immunity in Burned Mice. Nutrition. 2009;25(2):233-9. PubMed PMID: 18977117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice. AU - Fan,Jun, AU - Meng,Qingyan, AU - Guo,Guanghua, AU - Xie,Yong, AU - Xiu,Yiping, AU - Li,Tairan, AU - Feng,Wei, AU - Ma,Liang, Y1 - 2008/10/31/ PY - 2008/04/08/received PY - 2008/08/11/revised PY - 2008/08/30/accepted PY - 2008/11/4/pubmed PY - 2009/4/17/medline PY - 2008/11/4/entrez SP - 233 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 25 IS - 2 N2 - OBJECTIVE: The aim of this study was to investigate the effects of enteral nutrition (EN) supplemented with glutamine (GLN) on Peyer's patches and intestinal immunoglobulin A (IgA) response in burned mice. METHODS: Thirty-four mice were randomly assigned to a normal control group (n = 10), an EN group (n = 12), and an EN supplemented with GLN (EN + GLN) group (n = 12) and mice in the EN and EN + GLN groups received a 20% total body surface area, full-thickness scald burn on the back. Then the burned mice were fed with conventional EN or EN + GLN for 7 d. There was isonitrogenous and isocaloric intake in the EN and EN + GLN groups. On day 7 after injury, entire intestines were collected and intestinal IgA levels, total lymphocyte yield, lymphocyte subpopulations, and total apoptotic ratio in Peyer's patches were analyzed. RESULTS: Total lymphocyte yield, numbers of lymphocyte subpopulations, and intestinal IgA levels in the EN + GLN group were significantly higher than those in the EN group (P < 0.05). The total apoptotic ratio in Peyer's patches was markedly decreased in the EN + GLN group compared with that in the EN group (P < 0.05). CONCLUSION: The results indicated that EN supplemented with GLN is superior to conventional EN with respect to improvement of intestinal immunity in burned mice. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18977117/Effects_of_enteral_nutrition_supplemented_with_glutamine_on_intestinal_mucosal_immunity_in_burned_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00385-7 DB - PRIME DP - Unbound Medicine ER -