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No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study.
J Am Coll Nutr. 2008 Aug; 27(4):463-9.JA

Abstract

OBJECTIVE

The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people.

DESIGN

Multicentre prospective intervention study, randomized, double-blind, placebo-control.

SETTING

France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine).

SUBJECTS

A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months.

METHODS

Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months.

RESULTS

Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity.

CONCLUSIONS

In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.

Authors+Show Affiliations

Andriollo-Sanchez M
INSERM and LBFA, Université J. Fourier, Grenoble, France.
Hininger-Favier I
No affiliation info available
Meunier N
No affiliation info available
Venneria E
No affiliation info available
O'Connor JM
No affiliation info available
Maiani G
No affiliation info available
Polito A
No affiliation info available
Bord S
No affiliation info available
Ferry M
No affiliation info available
Coudray C
No affiliation info available
Roussel AM
No affiliation info available

MeSH

AgedAged, 80 and overAntioxidantsBiomarkersCreatinineDietary SupplementsDouble-Blind MethodHumansIsoprostanesLipid PeroxidationMiddle AgedOxidative StressSuperoxide DismutaseZinc

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18978165

Citation

Andriollo-Sanchez, Maud, et al. "No Antioxidant Beneficial Effect of Zinc Supplementation On Oxidative Stress Markers and Antioxidant Defenses in Middle-aged and Elderly Subjects: the Zenith Study." Journal of the American College of Nutrition, vol. 27, no. 4, 2008, pp. 463-9.
Andriollo-Sanchez M, Hininger-Favier I, Meunier N, et al. No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. J Am Coll Nutr. 2008;27(4):463-9.
Andriollo-Sanchez, M., Hininger-Favier, I., Meunier, N., Venneria, E., O'Connor, J. M., Maiani, G., Polito, A., Bord, S., Ferry, M., Coudray, C., & Roussel, A. M. (2008). No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. Journal of the American College of Nutrition, 27(4), 463-9.
Andriollo-Sanchez M, et al. No Antioxidant Beneficial Effect of Zinc Supplementation On Oxidative Stress Markers and Antioxidant Defenses in Middle-aged and Elderly Subjects: the Zenith Study. J Am Coll Nutr. 2008;27(4):463-9. PubMed PMID: 18978165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. AU - Andriollo-Sanchez,Maud, AU - Hininger-Favier,Isabelle, AU - Meunier,Nathalie, AU - Venneria,Eugenia, AU - O'Connor,Jacqueline M, AU - Maiani,Giuseppe, AU - Polito,Angela, AU - Bord,Séverine, AU - Ferry,Monique, AU - Coudray,Charles, AU - Roussel,Anne-Marie, PY - 2008/11/4/pubmed PY - 2009/1/24/medline PY - 2008/11/4/entrez SP - 463 EP - 9 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 27 IS - 4 N2 - OBJECTIVE: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. DESIGN: Multicentre prospective intervention study, randomized, double-blind, placebo-control. SETTING: France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine). SUBJECTS: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. METHODS: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. RESULTS: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. CONCLUSIONS: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/18978165/No_antioxidant_beneficial_effect_of_zinc_supplementation_on_oxidative_stress_markers_and_antioxidant_defenses_in_middle_aged_and_elderly_subjects:_the_Zenith_study_ DB - PRIME DP - Unbound Medicine ER -