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No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study.
J Am Coll Nutr. 2008 Aug; 27(4):463-9.JA

Abstract

OBJECTIVE

The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people.

DESIGN

Multicentre prospective intervention study, randomized, double-blind, placebo-control.

SETTING

France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine).

SUBJECTS

A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months.

METHODS

Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months.

RESULTS

Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity.

CONCLUSIONS

In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.

Authors+Show Affiliations

INSERM and LBFA, Université J. Fourier, Grenoble, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18978165

Citation

Andriollo-Sanchez, Maud, et al. "No Antioxidant Beneficial Effect of Zinc Supplementation On Oxidative Stress Markers and Antioxidant Defenses in Middle-aged and Elderly Subjects: the Zenith Study." Journal of the American College of Nutrition, vol. 27, no. 4, 2008, pp. 463-9.
Andriollo-Sanchez M, Hininger-Favier I, Meunier N, et al. No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. J Am Coll Nutr. 2008;27(4):463-9.
Andriollo-Sanchez, M., Hininger-Favier, I., Meunier, N., Venneria, E., O'Connor, J. M., Maiani, G., Polito, A., Bord, S., Ferry, M., Coudray, C., & Roussel, A. M. (2008). No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. Journal of the American College of Nutrition, 27(4), 463-9.
Andriollo-Sanchez M, et al. No Antioxidant Beneficial Effect of Zinc Supplementation On Oxidative Stress Markers and Antioxidant Defenses in Middle-aged and Elderly Subjects: the Zenith Study. J Am Coll Nutr. 2008;27(4):463-9. PubMed PMID: 18978165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study. AU - Andriollo-Sanchez,Maud, AU - Hininger-Favier,Isabelle, AU - Meunier,Nathalie, AU - Venneria,Eugenia, AU - O'Connor,Jacqueline M, AU - Maiani,Giuseppe, AU - Polito,Angela, AU - Bord,Séverine, AU - Ferry,Monique, AU - Coudray,Charles, AU - Roussel,Anne-Marie, PY - 2008/11/4/pubmed PY - 2009/1/24/medline PY - 2008/11/4/entrez SP - 463 EP - 9 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 27 IS - 4 N2 - OBJECTIVE: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. DESIGN: Multicentre prospective intervention study, randomized, double-blind, placebo-control. SETTING: France (Clermont-Ferrand/Theix, and Grenoble), Italy (Rome), Northern Ireland (Coleraine). SUBJECTS: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. METHODS: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. RESULTS: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly, after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. CONCLUSIONS: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/18978165/No_antioxidant_beneficial_effect_of_zinc_supplementation_on_oxidative_stress_markers_and_antioxidant_defenses_in_middle_aged_and_elderly_subjects:_the_Zenith_study_ L2 - https://www.tandfonline.com/doi/full/10.1080/07315724.2008.10719726 DB - PRIME DP - Unbound Medicine ER -