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Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases.
Acta Radiol. 2008 Dec; 49(10):1167-73.AR

Abstract

BACKGROUND

Precisely defining the number and location of brain metastases is very important for establishing a treatment strategy for malignancies. Although magnetic resonance imaging (MRI) is now considered the best modality, various improvements in sequences are still being made.

PURPOSE

To prospectively compare the diagnostic ability of three-dimensional, magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging in detecting metastatic brain tumors, with that of two-dimensional spin-echo (2D SE) T1-weighted imaging.

MATERIAL AND METHODS

A total of 123 examinations were included in this study, and 119 examinations from 88 patients with known malignancies were analyzed. All patients underwent T1- and T2-weighted 2D SE transverse imaging, followed by gadolinium-enhanced T1-weighted transverse and coronal 2D SE imaging and 3D MP-RAGE transverse imaging. Four radiologists interpreted the images to compare the accuracy and the time required for interpretation for each imaging.

RESULTS

3D MP-RAGE imaging was significantly better than 2D SE imaging for detecting metastatic brain lesions, regardless of the readers' experience. The sensitivities of the 3D MP-RAGE and 2D SE imaging for all observers were 0.81 vs. 0.80 (P>0.05), specificities were 0.93 vs. 0.87 (P<0.05), positive predictive values were 0.92 vs. 0.86 (P<0.05), negative predictive values were 0.78 vs. 0.75 (P>0.05), and accuracies were 0.84 vs. 0.78 (P<0.05), respectively. There was no significant difference in the time required for image interpretation between the two modalities (15.6+/-4.0 vs. 15.4+/-4.1 min).

CONCLUSION

3D MP-RAGE imaging proved superior to 2D SE imaging in the detection of brain metastases.

Authors+Show Affiliations

Department of Radiology, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18979271

Citation

Takeda, T, et al. "Gadolinium-enhanced Three-dimensional Magnetization-prepared Rapid Gradient-echo (3D MP-RAGE) Imaging Is Superior to Spin-echo Imaging in Delineating Brain Metastases." Acta Radiologica (Stockholm, Sweden : 1987), vol. 49, no. 10, 2008, pp. 1167-73.
Takeda T, Takeda A, Nagaoka T, et al. Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. Acta Radiol. 2008;49(10):1167-73.
Takeda, T., Takeda, A., Nagaoka, T., Kunieda, E., Takemasa, K., Watanabe, M., Hatou, T., Oguro, S., & Katayama, M. (2008). Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. Acta Radiologica (Stockholm, Sweden : 1987), 49(10), 1167-73. https://doi.org/10.1080/02841850802477924
Takeda T, et al. Gadolinium-enhanced Three-dimensional Magnetization-prepared Rapid Gradient-echo (3D MP-RAGE) Imaging Is Superior to Spin-echo Imaging in Delineating Brain Metastases. Acta Radiol. 2008;49(10):1167-73. PubMed PMID: 18979271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases. AU - Takeda,T, AU - Takeda,A, AU - Nagaoka,T, AU - Kunieda,E, AU - Takemasa,K, AU - Watanabe,M, AU - Hatou,T, AU - Oguro,S, AU - Katayama,M, PY - 2008/11/4/pubmed PY - 2008/12/19/medline PY - 2008/11/4/entrez SP - 1167 EP - 73 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 49 IS - 10 N2 - BACKGROUND: Precisely defining the number and location of brain metastases is very important for establishing a treatment strategy for malignancies. Although magnetic resonance imaging (MRI) is now considered the best modality, various improvements in sequences are still being made. PURPOSE: To prospectively compare the diagnostic ability of three-dimensional, magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging in detecting metastatic brain tumors, with that of two-dimensional spin-echo (2D SE) T1-weighted imaging. MATERIAL AND METHODS: A total of 123 examinations were included in this study, and 119 examinations from 88 patients with known malignancies were analyzed. All patients underwent T1- and T2-weighted 2D SE transverse imaging, followed by gadolinium-enhanced T1-weighted transverse and coronal 2D SE imaging and 3D MP-RAGE transverse imaging. Four radiologists interpreted the images to compare the accuracy and the time required for interpretation for each imaging. RESULTS: 3D MP-RAGE imaging was significantly better than 2D SE imaging for detecting metastatic brain lesions, regardless of the readers' experience. The sensitivities of the 3D MP-RAGE and 2D SE imaging for all observers were 0.81 vs. 0.80 (P>0.05), specificities were 0.93 vs. 0.87 (P<0.05), positive predictive values were 0.92 vs. 0.86 (P<0.05), negative predictive values were 0.78 vs. 0.75 (P>0.05), and accuracies were 0.84 vs. 0.78 (P<0.05), respectively. There was no significant difference in the time required for image interpretation between the two modalities (15.6+/-4.0 vs. 15.4+/-4.1 min). CONCLUSION: 3D MP-RAGE imaging proved superior to 2D SE imaging in the detection of brain metastases. SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/18979271/Gadolinium_enhanced_three_dimensional_magnetization_prepared_rapid_gradient_echo__3D_MP_RAGE__imaging_is_superior_to_spin_echo_imaging_in_delineating_brain_metastases_ L2 - https://journals.sagepub.com/doi/10.1080/02841850802477924?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -