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Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet.
Int J Food Sci Nutr 2008; 59(5):357-67IJ

Abstract

This study examined the effect of plant sterols added, together with an emulsifying agent, to a low-fat yoghurt on the serum lipid and plant sterol values in moderately hypercholesterolaemic volunteers. Study I was a randomized double-blind, cross-over trial. For 4 weeks, 15 volunteers consumed yoghurt containing 1 g plant sterols or a placebo yoghurt. Study II was a randomized, double-blind, parallel-group study. For 8 weeks, the sterol group (n = 12) ingested daily two yoghurts (2 g/day plant sterols) and the placebo group (n = 14) ingested two yoghurts without plant sterols. Study I: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.15 mmol/l (2.2%, P=0.235) and low-density lipoprotein (LDL) cholesterol by 0.19 mmol/l (4.3%, P=0.082), and increased serum campesterol by 0.26 mg/100 ml (P=0.006) and sitosterol by 0.11 mg/100 ml (P=0.015). Study II: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.41 mmol/l (6.3%, P=0.167) and LDL cholesterol by 0.28 mmol/l (6.4%, P=0.306), and increased serum campesterol by 0.28 mg/100 ml (P=0.016) and sitosterol by 0.40 mg/100 ml (P=0.206). Meta-analysis: the pooled treatment difference was -0.34 mmol/l (5.2%, P=0.173) in total cholesterol and was -0.26 mmol/l (-5.8%, P=0.261) in LDL cholesterol, when the sterol yoghurt was compared with the placebo. A low-fat yoghurt enriched with 1-2 g/day plant sterols reduced serum cholesterol levels in moderately hypercholesterolaemic subjects. Campesterol and sitosterol serum levels increased, but their concentration remained in the range of normal values.

Authors+Show Affiliations

Vihti, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18979616

Citation

Niittynen, Leena H., et al. "Effects of Yoghurt Enriched With Free Plant Sterols On the Levels of Serum Lipids and Plant Sterols in Moderately Hypercholesterolaemic Subjects On a High-fat Diet." International Journal of Food Sciences and Nutrition, vol. 59, no. 5, 2008, pp. 357-67.
Niittynen LH, Jauhiainen TA, Poussa TA, et al. Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet. Int J Food Sci Nutr. 2008;59(5):357-67.
Niittynen, L. H., Jauhiainen, T. A., Poussa, T. A., & Korpela, R. (2008). Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet. International Journal of Food Sciences and Nutrition, 59(5), pp. 357-67.
Niittynen LH, et al. Effects of Yoghurt Enriched With Free Plant Sterols On the Levels of Serum Lipids and Plant Sterols in Moderately Hypercholesterolaemic Subjects On a High-fat Diet. Int J Food Sci Nutr. 2008;59(5):357-67. PubMed PMID: 18979616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet. AU - Niittynen,Leena H, AU - Jauhiainen,Tiina A, AU - Poussa,Tuija A, AU - Korpela,Riitta, PY - 2008/11/4/pubmed PY - 2009/1/14/medline PY - 2008/11/4/entrez SP - 357 EP - 67 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 59 IS - 5 N2 - This study examined the effect of plant sterols added, together with an emulsifying agent, to a low-fat yoghurt on the serum lipid and plant sterol values in moderately hypercholesterolaemic volunteers. Study I was a randomized double-blind, cross-over trial. For 4 weeks, 15 volunteers consumed yoghurt containing 1 g plant sterols or a placebo yoghurt. Study II was a randomized, double-blind, parallel-group study. For 8 weeks, the sterol group (n = 12) ingested daily two yoghurts (2 g/day plant sterols) and the placebo group (n = 14) ingested two yoghurts without plant sterols. Study I: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.15 mmol/l (2.2%, P=0.235) and low-density lipoprotein (LDL) cholesterol by 0.19 mmol/l (4.3%, P=0.082), and increased serum campesterol by 0.26 mg/100 ml (P=0.006) and sitosterol by 0.11 mg/100 ml (P=0.015). Study II: compared with the placebo, the sterol yoghurt reduced serum total cholesterol by 0.41 mmol/l (6.3%, P=0.167) and LDL cholesterol by 0.28 mmol/l (6.4%, P=0.306), and increased serum campesterol by 0.28 mg/100 ml (P=0.016) and sitosterol by 0.40 mg/100 ml (P=0.206). Meta-analysis: the pooled treatment difference was -0.34 mmol/l (5.2%, P=0.173) in total cholesterol and was -0.26 mmol/l (-5.8%, P=0.261) in LDL cholesterol, when the sterol yoghurt was compared with the placebo. A low-fat yoghurt enriched with 1-2 g/day plant sterols reduced serum cholesterol levels in moderately hypercholesterolaemic subjects. Campesterol and sitosterol serum levels increased, but their concentration remained in the range of normal values. SN - 0963-7486 UR - https://www.unboundmedicine.com/medline/citation/18979616/Effects_of_yoghurt_enriched_with_free_plant_sterols_on_the_levels_of_serum_lipids_and_plant_sterols_in_moderately_hypercholesterolaemic_subjects_on_a_high_fat_diet_ L2 - http://www.tandfonline.com/doi/full/10.1080/09637480701554137 DB - PRIME DP - Unbound Medicine ER -