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Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats.
Phytother Res. 2008 Dec; 22(12):1563-9.PR

Abstract

Intracerebroventricular (i.c.v.) administration of colchicine, a microtubule-disrupting agent, causes cognitive dysfunction and oxidative stress. The present study was designed to investigate the protective effects of quercetin against colchicine-induced memory impairment and oxidative damage in rats. An i.c.v. cannula was implanted in the lateral ventricle of male Wistar rats. Colchicine was administered at dose of 15 microg/rat. Morris water maze and plus-maze performance tests were used to assess memory tasks. Various biochemical parameters such as lipid peroxidation, reduced glutathione, nitrite level, acetylcholinesterase and proteins were also assessed. Central administration of colchicine (15 microg/rat) showed poor retention of memory. Chronic treatment with quercetin (20 and 40 mg/kg, p.o.) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment. Biochemical analysis revealed that i.c.v. colchicine injection significantly increased lipid peroxidation, nitrite and depleted reduced glutathione activity in the brains of rats. Chronic administration of quercetin significantly attenuated elevated lipid peroxidation and restored the depleted reduced glutathione, acetylcholinesterase activity and nitrite activity. The results of the present study clearly indicated that quercetin has a neuroprotective effect against colchicine-induced cognitive dysfunctions and oxidative damage. This article was published online on 3 November 2008. An error was subsequently identified. This notice is included in the online and print version to indicate that both have been corrected.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India. kumaruips@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18980205

Citation

Kumar, Anil, et al. "Protective Effect of Quercetin Against ICV Colchicine-induced Cognitive Dysfunctions and Oxidative Damage in Rats." Phytotherapy Research : PTR, vol. 22, no. 12, 2008, pp. 1563-9.
Kumar A, Sehgal N, Kumar P, et al. Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res. 2008;22(12):1563-9.
Kumar, A., Sehgal, N., Kumar, P., Padi, S. S., & Naidu, P. S. (2008). Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytotherapy Research : PTR, 22(12), 1563-9. https://doi.org/10.1002/ptr.2454
Kumar A, et al. Protective Effect of Quercetin Against ICV Colchicine-induced Cognitive Dysfunctions and Oxidative Damage in Rats. Phytother Res. 2008;22(12):1563-9. PubMed PMID: 18980205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. AU - Kumar,Anil, AU - Sehgal,Neha, AU - Kumar,Puneet, AU - Padi,S S V, AU - Naidu,P S, PY - 2008/11/5/entrez PY - 2008/11/5/pubmed PY - 2009/1/29/medline SP - 1563 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 12 N2 - Intracerebroventricular (i.c.v.) administration of colchicine, a microtubule-disrupting agent, causes cognitive dysfunction and oxidative stress. The present study was designed to investigate the protective effects of quercetin against colchicine-induced memory impairment and oxidative damage in rats. An i.c.v. cannula was implanted in the lateral ventricle of male Wistar rats. Colchicine was administered at dose of 15 microg/rat. Morris water maze and plus-maze performance tests were used to assess memory tasks. Various biochemical parameters such as lipid peroxidation, reduced glutathione, nitrite level, acetylcholinesterase and proteins were also assessed. Central administration of colchicine (15 microg/rat) showed poor retention of memory. Chronic treatment with quercetin (20 and 40 mg/kg, p.o.) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment. Biochemical analysis revealed that i.c.v. colchicine injection significantly increased lipid peroxidation, nitrite and depleted reduced glutathione activity in the brains of rats. Chronic administration of quercetin significantly attenuated elevated lipid peroxidation and restored the depleted reduced glutathione, acetylcholinesterase activity and nitrite activity. The results of the present study clearly indicated that quercetin has a neuroprotective effect against colchicine-induced cognitive dysfunctions and oxidative damage. This article was published online on 3 November 2008. An error was subsequently identified. This notice is included in the online and print version to indicate that both have been corrected. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18980205/Protective_effect_of_quercetin_against_ICV_colchicine_induced_cognitive_dysfunctions_and_oxidative_damage_in_rats_ L2 - https://doi.org/10.1002/ptr.2454 DB - PRIME DP - Unbound Medicine ER -