Tags

Type your tag names separated by a space and hit enter

Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia.
Arch Gen Psychiatry 2008; 65(11):1259-68AG

Abstract

CONTEXT

Structural brain abnormalities have consistently been found in schizophrenia, with increased familial risk for the disease associated with these abnormalities. Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-related factors is unknown.

OBJECTIVE

To investigate whether genetic and/or environmental factors are associated with progressive brain volume changes in schizophrenia.

DESIGN

Longitudinal 5-year follow-up in monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for schizophrenia and healthy comparison twin pairs using brain magnetic resonance imaging.

SETTING

Participants were recruited from the twin pair cohort at the University Medical Center Utrecht.

PARTICIPANTS

A total of 92 participants completed the study: 9 MZ and 10 DZ twin pairs discordant for schizophrenia and 14 MZ and 13 DZ healthy twin pairs.

MAIN OUTCOME MEASURES

Percentage volume changes of the whole brain; cerebral gray and white matter of the frontal, temporal, parietal, and occipital lobes; cerebellum; and lateral and third ventricles over time between and within twin pairs were compared using repeated measures analysis of covariance. Structural equation modeling was applied to estimate contributions of additive genetic and common and unique environmental factors.

RESULTS

Significant decreases over time in whole brain and frontal and temporal lobe volumes were found in patients with schizophrenia and their unaffected co-twins compared with control twins. Bivariate structural equation modeling using cross-trait/cross-twin correlations revealed significant additive genetic influences on the correlations between schizophrenia liability and progressive whole brain (66%; 95% confidence interval [CI], 51%-100%), frontal lobe (76%; 95% CI, 54%-100%), and temporal lobe (79%; CI, 56%-100%) volume change.

CONCLUSION

The progressive brain volume loss found in patients with schizophrenia and their unaffected co-twins is at least partly attributable to genetic factors related to the illness.

Authors+Show Affiliations

Department of Psychiatry, A01-126, University Medical Center Utrecht, Heidelberglaan 100, Utrecht CX 3584, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

18981337

Citation

Brans, Rachel G H., et al. "Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia." Archives of General Psychiatry, vol. 65, no. 11, 2008, pp. 1259-68.
Brans RG, van Haren NE, van Baal GC, et al. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch Gen Psychiatry. 2008;65(11):1259-68.
Brans, R. G., van Haren, N. E., van Baal, G. C., Schnack, H. G., Kahn, R. S., & Hulshoff Pol, H. E. (2008). Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Archives of General Psychiatry, 65(11), pp. 1259-68. doi:10.1001/archpsyc.65.11.1259.
Brans RG, et al. Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia. Arch Gen Psychiatry. 2008;65(11):1259-68. PubMed PMID: 18981337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. AU - Brans,Rachel G H, AU - van Haren,Neeltje E M, AU - van Baal,G Caroline M, AU - Schnack,Hugo G, AU - Kahn,René S, AU - Hulshoff Pol,Hilleke E, PY - 2008/11/5/pubmed PY - 2008/11/19/medline PY - 2008/11/5/entrez SP - 1259 EP - 68 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 65 IS - 11 N2 - CONTEXT: Structural brain abnormalities have consistently been found in schizophrenia, with increased familial risk for the disease associated with these abnormalities. Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-related factors is unknown. OBJECTIVE: To investigate whether genetic and/or environmental factors are associated with progressive brain volume changes in schizophrenia. DESIGN: Longitudinal 5-year follow-up in monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for schizophrenia and healthy comparison twin pairs using brain magnetic resonance imaging. SETTING: Participants were recruited from the twin pair cohort at the University Medical Center Utrecht. PARTICIPANTS: A total of 92 participants completed the study: 9 MZ and 10 DZ twin pairs discordant for schizophrenia and 14 MZ and 13 DZ healthy twin pairs. MAIN OUTCOME MEASURES: Percentage volume changes of the whole brain; cerebral gray and white matter of the frontal, temporal, parietal, and occipital lobes; cerebellum; and lateral and third ventricles over time between and within twin pairs were compared using repeated measures analysis of covariance. Structural equation modeling was applied to estimate contributions of additive genetic and common and unique environmental factors. RESULTS: Significant decreases over time in whole brain and frontal and temporal lobe volumes were found in patients with schizophrenia and their unaffected co-twins compared with control twins. Bivariate structural equation modeling using cross-trait/cross-twin correlations revealed significant additive genetic influences on the correlations between schizophrenia liability and progressive whole brain (66%; 95% confidence interval [CI], 51%-100%), frontal lobe (76%; 95% CI, 54%-100%), and temporal lobe (79%; CI, 56%-100%) volume change. CONCLUSION: The progressive brain volume loss found in patients with schizophrenia and their unaffected co-twins is at least partly attributable to genetic factors related to the illness. SN - 1538-3636 UR - https://www.unboundmedicine.com/medline/citation/18981337/Heritability_of_changes_in_brain_volume_over_time_in_twin_pairs_discordant_for_schizophrenia_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18981337.ui DB - PRIME DP - Unbound Medicine ER -