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Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis.
JOP. 2008 Nov 03; 9(6):683-9.JOP

Abstract

CONTEXT

Histopathological analysis has demonstrated lymphocytic infiltration in both the endocrine and the exocrine pancreas in some patients with type 1 diabetes and non-alcoholic chronic pancreatitis, suggesting an immune-mediated mechanism which affects both diabetes mellitus and chronic pancreatitis.

OBJECTIVE

The examination of exocrine pancreatic humoral markers in Caucasian patients with respect to the interactions between exocrine and endocrine pancreatic diseases.

PATIENTS

One hundred and thirty-six European Caucasian subjects subdivided into three groups: type 1 diabetes (n=48); non-alcoholic chronic pancreatitis (n=48); controls (n=40).

MAIN OUTCOME MEASURE

Autoantibodies against carbonic anhydrase II (CAIIAb) and lactoferrin (LACAb) (both of which are exocrine pancreatic antigens) were analyzed by enzyme-linked immunosorbent assay.

RESULTS

No positivity for CAIIAb and LACAb were found in the controls. Patients with type 1 diabetes had a significantly higher prevalence of CAIIAb (25.0%) than the controls while the prevalence of LACAb (8.3%) was not significantly higher than the controls. The prevalence of CAIIAb (12.5%) and LACAb (20.8%) in the patients with non-alcoholic chronic pancreatitis was significantly higher than that in the controls. A significantly higher prevalence of CAIIAb and/or LACAb was found in patients with type 1 diabetes (29.2%) and non-alcoholic chronic pancreatitis (22.9%) compared to that in the controls (0%). There was a significant association between CAIIAb and LACAb titers both in patients with type 1 diabetes (P=0.042) and in patients with non-alcoholic chronic pancreatitis (P<0.001).

CONCLUSION

We have clearly demonstrated that some European Caucasian patients with type 1 diabetes and non-alcoholic chronic pancreatitis have autoantibodies against the exocrine pancreatic antigens CAIIAb and LACAb.

Authors+Show Affiliations

Third Medical Department, University Hospital Giessen and Marburg, Giessen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18981548

Citation

Hardt, Philip D., et al. "Distinct Autoantibodies Against Exocrine Pancreatic Antigens in European Patients With Type 1 Diabetes Mellitus and Non-alcoholic Chronic Pancreatitis." JOP : Journal of the Pancreas, vol. 9, no. 6, 2008, pp. 683-9.
Hardt PD, Ewald N, Bröckling K, et al. Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis. JOP. 2008;9(6):683-9.
Hardt, P. D., Ewald, N., Bröckling, K., Tanaka, S., Endo, T., Kloer, H. U., Bretzel, R. G., Jaeger, C., Shimura, H., & Kobayashi, T. (2008). Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis. JOP : Journal of the Pancreas, 9(6), 683-9.
Hardt PD, et al. Distinct Autoantibodies Against Exocrine Pancreatic Antigens in European Patients With Type 1 Diabetes Mellitus and Non-alcoholic Chronic Pancreatitis. JOP. 2008 Nov 3;9(6):683-9. PubMed PMID: 18981548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis. AU - Hardt,Philip D, AU - Ewald,Nils, AU - Bröckling,Kristian, AU - Tanaka,Shoichiro, AU - Endo,Toyoshi, AU - Kloer,Hans U, AU - Bretzel,Reinhard G, AU - Jaeger,Clemens, AU - Shimura,Hiroki, AU - Kobayashi,Tetsuro, Y1 - 2008/11/03/ PY - 2008/11/5/pubmed PY - 2008/12/30/medline PY - 2008/11/5/entrez SP - 683 EP - 9 JF - JOP : Journal of the pancreas JO - JOP VL - 9 IS - 6 N2 - CONTEXT: Histopathological analysis has demonstrated lymphocytic infiltration in both the endocrine and the exocrine pancreas in some patients with type 1 diabetes and non-alcoholic chronic pancreatitis, suggesting an immune-mediated mechanism which affects both diabetes mellitus and chronic pancreatitis. OBJECTIVE: The examination of exocrine pancreatic humoral markers in Caucasian patients with respect to the interactions between exocrine and endocrine pancreatic diseases. PATIENTS: One hundred and thirty-six European Caucasian subjects subdivided into three groups: type 1 diabetes (n=48); non-alcoholic chronic pancreatitis (n=48); controls (n=40). MAIN OUTCOME MEASURE: Autoantibodies against carbonic anhydrase II (CAIIAb) and lactoferrin (LACAb) (both of which are exocrine pancreatic antigens) were analyzed by enzyme-linked immunosorbent assay. RESULTS: No positivity for CAIIAb and LACAb were found in the controls. Patients with type 1 diabetes had a significantly higher prevalence of CAIIAb (25.0%) than the controls while the prevalence of LACAb (8.3%) was not significantly higher than the controls. The prevalence of CAIIAb (12.5%) and LACAb (20.8%) in the patients with non-alcoholic chronic pancreatitis was significantly higher than that in the controls. A significantly higher prevalence of CAIIAb and/or LACAb was found in patients with type 1 diabetes (29.2%) and non-alcoholic chronic pancreatitis (22.9%) compared to that in the controls (0%). There was a significant association between CAIIAb and LACAb titers both in patients with type 1 diabetes (P=0.042) and in patients with non-alcoholic chronic pancreatitis (P<0.001). CONCLUSION: We have clearly demonstrated that some European Caucasian patients with type 1 diabetes and non-alcoholic chronic pancreatitis have autoantibodies against the exocrine pancreatic antigens CAIIAb and LACAb. SN - 1590-8577 UR - https://www.unboundmedicine.com/medline/citation/18981548/Distinct_autoantibodies_against_exocrine_pancreatic_antigens_in_European_patients_with_type_1_diabetes_mellitus_and_non_alcoholic_chronic_pancreatitis_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -