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Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS.
Anal Bioanal Chem. 2009 Jan; 393(2):709-18.AB

Abstract

An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography-tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a TurboIonSpray source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis.

Authors+Show Affiliations

Department of Food Science, University of Teramo, Via C. R. Lerici 1, Mosciano S.A., 64023, Teramo, Italy. msergi@unite.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18982317

Citation

Sergi, M, et al. "Multiclass Analysis of Illicit Drugs in Plasma and Oral Fluids By LC-MS/MS." Analytical and Bioanalytical Chemistry, vol. 393, no. 2, 2009, pp. 709-18.
Sergi M, Bafile E, Compagnone D, et al. Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS. Anal Bioanal Chem. 2009;393(2):709-18.
Sergi, M., Bafile, E., Compagnone, D., Curini, R., D'Ascenzo, G., & Romolo, F. S. (2009). Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS. Analytical and Bioanalytical Chemistry, 393(2), 709-18. https://doi.org/10.1007/s00216-008-2456-3
Sergi M, et al. Multiclass Analysis of Illicit Drugs in Plasma and Oral Fluids By LC-MS/MS. Anal Bioanal Chem. 2009;393(2):709-18. PubMed PMID: 18982317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS. AU - Sergi,M, AU - Bafile,E, AU - Compagnone,D, AU - Curini,R, AU - D'Ascenzo,G, AU - Romolo,F S, Y1 - 2008/11/04/ PY - 2008/07/07/received PY - 2008/10/02/accepted PY - 2008/10/01/revised PY - 2008/11/5/pubmed PY - 2009/2/12/medline PY - 2008/11/5/entrez SP - 709 EP - 18 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 393 IS - 2 N2 - An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography-tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a TurboIonSpray source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/18982317/Multiclass_analysis_of_illicit_drugs_in_plasma_and_oral_fluids_by_LC_MS/MS_ L2 - https://dx.doi.org/10.1007/s00216-008-2456-3 DB - PRIME DP - Unbound Medicine ER -