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Influence of fibrinogen beta-chain gene variations on risk of myocardial infarction in a Chinese Han population.
Chin Med J (Engl). 2008 Aug 20; 121(16):1549-53.CM

Abstract

BACKGROUND

Although the role of fibrinogen as a predictor of acute myocardial infarction (MI) has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen beta-chain (FGB) gene and MI in Chinese Han population.

METHODS

The occurrence of 3 common polymorphisms (i.e., -455G/A, R448K and 8558C/G) in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors (adjusted odds ratio(OR) = 0.71 for KK/RK versus RR, P = 0.023). The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype (-455A, 448K, 8558G) was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 (95% CI, 0.51-0.90; P = 0.006).

CONCLUSION

These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population.

Authors+Show Affiliations

Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18982866

Citation

Lu, Xiang-feng, et al. "Influence of Fibrinogen Beta-chain Gene Variations On Risk of Myocardial Infarction in a Chinese Han Population." Chinese Medical Journal, vol. 121, no. 16, 2008, pp. 1549-53.
Lu XF, Yu HJ, Zhou XY, et al. Influence of fibrinogen beta-chain gene variations on risk of myocardial infarction in a Chinese Han population. Chin Med J (Engl). 2008;121(16):1549-53.
Lu, X. F., Yu, H. J., Zhou, X. Y., Wang, L. Y., Huang, J. F., & Gu, D. F. (2008). Influence of fibrinogen beta-chain gene variations on risk of myocardial infarction in a Chinese Han population. Chinese Medical Journal, 121(16), 1549-53.
Lu XF, et al. Influence of Fibrinogen Beta-chain Gene Variations On Risk of Myocardial Infarction in a Chinese Han Population. Chin Med J (Engl). 2008 Aug 20;121(16):1549-53. PubMed PMID: 18982866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of fibrinogen beta-chain gene variations on risk of myocardial infarction in a Chinese Han population. AU - Lu,Xiang-feng, AU - Yu,Hong-jiang, AU - Zhou,Xiao-yang, AU - Wang,Lai-yuan, AU - Huang,Jian-feng, AU - Gu,Dong-feng, PY - 2008/11/6/pubmed PY - 2008/12/17/medline PY - 2008/11/6/entrez SP - 1549 EP - 53 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 121 IS - 16 N2 - BACKGROUND: Although the role of fibrinogen as a predictor of acute myocardial infarction (MI) has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen beta-chain (FGB) gene and MI in Chinese Han population. METHODS: The occurrence of 3 common polymorphisms (i.e., -455G/A, R448K and 8558C/G) in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors (adjusted odds ratio(OR) = 0.71 for KK/RK versus RR, P = 0.023). The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype (-455A, 448K, 8558G) was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 (95% CI, 0.51-0.90; P = 0.006). CONCLUSION: These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/18982866/Influence_of_fibrinogen_beta_chain_gene_variations_on_risk_of_myocardial_infarction_in_a_Chinese_Han_population_ L2 - https://Insights.ovid.com/pubmed?pmid=18982866 DB - PRIME DP - Unbound Medicine ER -