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TLR4 and IL-18 gene variants in aggressive periodontitis.
J Clin Periodontol. 2008 Dec; 35(12):1020-6.JC

Abstract

AIM

We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants in the pathogen-recognition receptor Toll-like receptor 4 (TLR4) and variants in the promoter region of the pro-inflammatory cytokine interleukin-18 (IL-18).

MATERIAL AND METHODS

One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A). The genotype and allele frequencies, as well as the frequency of combined genotypes were compared between study groups.

RESULTS

There were no statistical differences in genotype and allele frequencies within the four variants between the groups. All study subjects were further classified into carriers and non-carriers of at least one variant of both genes. The logistic regression analysis adjusted for gender and smoking showed no association between carrier status of at least one variant of both genes and periodontal status (OR=1.41, 95% CI: 0.43-4.70).

CONCLUSIONS

Our results reject the hypothesis that functionally relevant IL-18 and TLR4 gene mutations have a major effect on aggressive periodontitis susceptibility alone or in combination.

Authors+Show Affiliations

Department of Conservative Dentistry, Medical Faculty Carl Gustav Carus, TU Dresden, Germany. Barbara.Noack@uniklinikum-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18983635

Citation

Noack, Barbara, et al. "TLR4 and IL-18 Gene Variants in Aggressive Periodontitis." Journal of Clinical Periodontology, vol. 35, no. 12, 2008, pp. 1020-6.
Noack B, Görgens H, Lorenz K, et al. TLR4 and IL-18 gene variants in aggressive periodontitis. J Clin Periodontol. 2008;35(12):1020-6.
Noack, B., Görgens, H., Lorenz, K., Ziegler, A., Hoffmann, T., & Schackert, H. K. (2008). TLR4 and IL-18 gene variants in aggressive periodontitis. Journal of Clinical Periodontology, 35(12), 1020-6. https://doi.org/10.1111/j.1600-051X.2008.01334.x
Noack B, et al. TLR4 and IL-18 Gene Variants in Aggressive Periodontitis. J Clin Periodontol. 2008;35(12):1020-6. PubMed PMID: 18983635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TLR4 and IL-18 gene variants in aggressive periodontitis. AU - Noack,Barbara, AU - Görgens,Heike, AU - Lorenz,Katrin, AU - Ziegler,Andreas, AU - Hoffmann,Thomas, AU - Schackert,Hans Konrad, Y1 - 2008/10/28/ PY - 2008/11/6/pubmed PY - 2009/3/5/medline PY - 2008/11/6/entrez SP - 1020 EP - 6 JF - Journal of clinical periodontology JO - J Clin Periodontol VL - 35 IS - 12 N2 - AIM: We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants in the pathogen-recognition receptor Toll-like receptor 4 (TLR4) and variants in the promoter region of the pro-inflammatory cytokine interleukin-18 (IL-18). MATERIAL AND METHODS: One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A). The genotype and allele frequencies, as well as the frequency of combined genotypes were compared between study groups. RESULTS: There were no statistical differences in genotype and allele frequencies within the four variants between the groups. All study subjects were further classified into carriers and non-carriers of at least one variant of both genes. The logistic regression analysis adjusted for gender and smoking showed no association between carrier status of at least one variant of both genes and periodontal status (OR=1.41, 95% CI: 0.43-4.70). CONCLUSIONS: Our results reject the hypothesis that functionally relevant IL-18 and TLR4 gene mutations have a major effect on aggressive periodontitis susceptibility alone or in combination. SN - 1600-051X UR - https://www.unboundmedicine.com/medline/citation/18983635/TLR4_and_IL_18_gene_variants_in_aggressive_periodontitis_ L2 - https://doi.org/10.1111/j.1600-051X.2008.01334.x DB - PRIME DP - Unbound Medicine ER -