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High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis.
BMC Pulm Med. 2008 Nov 04; 8:23.BP

Abstract

BACKGROUND

The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UIP). Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is increased in various fibrotic diseases. We investigated the autoantibodies to HSP47 in IIPs.

METHODS

We measured the serum levels of the autoantibodies to HSP47 in 38 patients with various forms of IIP [16 with idiopathic pulmonary fibrosis (IPF), 15 with idiopathic NSIP, 7 with cryptogenic organizing pneumonia (COP)] and 18 healthy volunteers.

RESULTS

The serum levels of autoantibodies to HSP47 in patients with idiopathic NSIP were significantly higher than in patients with IPF (P < 0.01), COP (P < 0.05), and healthy volunteers (P < 0.05). In addition, those in fibrosing NSIP were significantly higher than those of cellular and fibrosing NSIP (p < 0.05).

CONCLUSION

We found high levels of anti-HSP47 autoantibody titers in sera of patients with idiopathic fibrosing NSIP compared with other IIPs and healthy volunteers.

Authors+Show Affiliations

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. tomoyukikakugawa@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18983650

Citation

Kakugawa, Tomoyuki, et al. "High Serum Concentrations of Autoantibodies to HSP47 in Nonspecific Interstitial Pneumonia Compared With Idiopathic Pulmonary Fibrosis." BMC Pulmonary Medicine, vol. 8, 2008, p. 23.
Kakugawa T, Yokota S, Mukae H, et al. High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis. BMC Pulm Med. 2008;8:23.
Kakugawa, T., Yokota, S., Mukae, H., Kubota, H., Sakamoto, N., Mizunoe, S., Matsuoka, Y., Kadota, J., Fujii, N., Nagata, K., & Kohno, S. (2008). High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis. BMC Pulmonary Medicine, 8, 23. https://doi.org/10.1186/1471-2466-8-23
Kakugawa T, et al. High Serum Concentrations of Autoantibodies to HSP47 in Nonspecific Interstitial Pneumonia Compared With Idiopathic Pulmonary Fibrosis. BMC Pulm Med. 2008 Nov 4;8:23. PubMed PMID: 18983650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis. AU - Kakugawa,Tomoyuki, AU - Yokota,Shin-ichi, AU - Mukae,Hiroshi, AU - Kubota,Hiroshi, AU - Sakamoto,Noriho, AU - Mizunoe,Syunji, AU - Matsuoka,Yasuhiro, AU - Kadota,Jun-ichi, AU - Fujii,Nobuhiro, AU - Nagata,Kazuhiro, AU - Kohno,Shigeru, Y1 - 2008/11/04/ PY - 2008/03/18/received PY - 2008/11/04/accepted PY - 2008/11/6/pubmed PY - 2008/12/17/medline PY - 2008/11/6/entrez SP - 23 EP - 23 JF - BMC pulmonary medicine JO - BMC Pulm Med VL - 8 N2 - BACKGROUND: The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UIP). Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is increased in various fibrotic diseases. We investigated the autoantibodies to HSP47 in IIPs. METHODS: We measured the serum levels of the autoantibodies to HSP47 in 38 patients with various forms of IIP [16 with idiopathic pulmonary fibrosis (IPF), 15 with idiopathic NSIP, 7 with cryptogenic organizing pneumonia (COP)] and 18 healthy volunteers. RESULTS: The serum levels of autoantibodies to HSP47 in patients with idiopathic NSIP were significantly higher than in patients with IPF (P < 0.01), COP (P < 0.05), and healthy volunteers (P < 0.05). In addition, those in fibrosing NSIP were significantly higher than those of cellular and fibrosing NSIP (p < 0.05). CONCLUSION: We found high levels of anti-HSP47 autoantibody titers in sera of patients with idiopathic fibrosing NSIP compared with other IIPs and healthy volunteers. SN - 1471-2466 UR - https://www.unboundmedicine.com/medline/citation/18983650/High_serum_concentrations_of_autoantibodies_to_HSP47_in_nonspecific_interstitial_pneumonia_compared_with_idiopathic_pulmonary_fibrosis_ L2 - https://bmcpulmmed.biomedcentral.com/articles/10.1186/1471-2466-8-23 DB - PRIME DP - Unbound Medicine ER -