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Molecular and geographic analyses of vampire bat-transmitted cattle rabies in central Brazil.
BMC Vet Res. 2008 Nov 05; 4:44.BV

Abstract

BACKGROUND

Vampire bats are important rabies virus vectors, causing critical problems in both the livestock industry and public health sector in Latin America. In order to assess the epidemiological characteristics of vampire bat-transmitted rabies, the authors conducted phylogenetic and geographical analyses using sequence data of a large number of cattle rabies isolates collected from a wide geographical area in Brazil.

METHODS

Partial nucleoprotein genes of rabies viruses isolated from 666 cattle and 18 vampire bats between 1987 and 2006 were sequenced and used for phylogenetic analysis. The genetic variants were plotted on topographical maps of Brazil.

RESULTS

In this study, 593 samples consisting of 24 genetic variants were analyzed. Regional localization of variants was observed, with the distribution of several variants found to be delimited by mountain ranges which served as geographic boundaries. The geographical distributions of vampire-bat and cattle isolates that were classified as the identical phylogenetic group were found to overlap with high certainty. Most of the samples analyzed in this study were isolated from adjacent areas linked by rivers.

CONCLUSION

This study revealed the existence of several dozen regional variants associated with vampire bats in Brazil, with the distribution patterns of these variants found to be affected by mountain ranges and rivers. These results suggest that epidemiological characteristics of vampire bat-related rabies appear to be associated with the topographical and geographical characteristics of areas where cattle are maintained, and the factors affecting vampire bat ecology.

Authors+Show Affiliations

Nihon University Veterinary Research Center, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. snow_poning@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18983685

Citation

Kobayashi, Yuki, et al. "Molecular and Geographic Analyses of Vampire Bat-transmitted Cattle Rabies in Central Brazil." BMC Veterinary Research, vol. 4, 2008, p. 44.
Kobayashi Y, Sato G, Mochizuki N, et al. Molecular and geographic analyses of vampire bat-transmitted cattle rabies in central Brazil. BMC Vet Res. 2008;4:44.
Kobayashi, Y., Sato, G., Mochizuki, N., Hirano, S., Itou, T., Carvalho, A. A., Albas, A., Santos, H. P., Ito, F. H., & Sakai, T. (2008). Molecular and geographic analyses of vampire bat-transmitted cattle rabies in central Brazil. BMC Veterinary Research, 4, 44. https://doi.org/10.1186/1746-6148-4-44
Kobayashi Y, et al. Molecular and Geographic Analyses of Vampire Bat-transmitted Cattle Rabies in Central Brazil. BMC Vet Res. 2008 Nov 5;4:44. PubMed PMID: 18983685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and geographic analyses of vampire bat-transmitted cattle rabies in central Brazil. AU - Kobayashi,Yuki, AU - Sato,Go, AU - Mochizuki,Nobuyuki, AU - Hirano,Shinji, AU - Itou,Takuya, AU - Carvalho,Adolorata A B, AU - Albas,Avelino, AU - Santos,Hamilton P, AU - Ito,Fumio H, AU - Sakai,Takeo, Y1 - 2008/11/05/ PY - 2008/04/28/received PY - 2008/11/05/accepted PY - 2008/11/6/pubmed PY - 2009/1/22/medline PY - 2008/11/6/entrez SP - 44 EP - 44 JF - BMC veterinary research JO - BMC Vet Res VL - 4 N2 - BACKGROUND: Vampire bats are important rabies virus vectors, causing critical problems in both the livestock industry and public health sector in Latin America. In order to assess the epidemiological characteristics of vampire bat-transmitted rabies, the authors conducted phylogenetic and geographical analyses using sequence data of a large number of cattle rabies isolates collected from a wide geographical area in Brazil. METHODS: Partial nucleoprotein genes of rabies viruses isolated from 666 cattle and 18 vampire bats between 1987 and 2006 were sequenced and used for phylogenetic analysis. The genetic variants were plotted on topographical maps of Brazil. RESULTS: In this study, 593 samples consisting of 24 genetic variants were analyzed. Regional localization of variants was observed, with the distribution of several variants found to be delimited by mountain ranges which served as geographic boundaries. The geographical distributions of vampire-bat and cattle isolates that were classified as the identical phylogenetic group were found to overlap with high certainty. Most of the samples analyzed in this study were isolated from adjacent areas linked by rivers. CONCLUSION: This study revealed the existence of several dozen regional variants associated with vampire bats in Brazil, with the distribution patterns of these variants found to be affected by mountain ranges and rivers. These results suggest that epidemiological characteristics of vampire bat-related rabies appear to be associated with the topographical and geographical characteristics of areas where cattle are maintained, and the factors affecting vampire bat ecology. SN - 1746-6148 UR - https://www.unboundmedicine.com/medline/citation/18983685/Molecular_and_geographic_analyses_of_vampire_bat_transmitted_cattle_rabies_in_central_Brazil_ L2 - https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-4-44 DB - PRIME DP - Unbound Medicine ER -