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Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis.
Br J Nutr. 2009 Jun; 101(12):1761-8.BJ

Abstract

Ethnicity-related differences in maternal n-3 and n-6 fatty acid status may be relevant to ethnic disparities in birth outcomes observed worldwide. The present study explored differences in early pregnancy n-3 and n-6 fatty acid composition of maternal plasma phospholipids between Dutch and ethnic minority pregnant women in Amsterdam, the Netherlands, with a focus on the major functional fatty acids EPA (20 : 5n-3), DHA (22 : 6n-3), dihomo-gamma-linolenic acid (DGLA; 20 : 3n-6) and arachidonic acid (AA; 20 : 4n-6). Data were derived from the Amsterdam Born Children and their Development (ABCD) cohort (inclusion January 2003 to March 2004). Compared with Dutch women (n 2443), Surinamese (n 286), Antillean (n 63), Turkish (n 167) and Moroccan (n 241) women had generally lower proportions of n-3 fatty acids (expressed as percentage of total fatty acids) but higher proportions of n-6 fatty acids (general linear model; P < 0.001). Ghanaian women (n 54) had higher proportions of EPA and DHA, but generally lower proportions of n-6 fatty acids (P < 0.001). Differences were most pronounced in Turkish and Ghanaian women, who, by means of a simple questionnaire, reported the lowest and highest fish consumption respectively. Adjustment for fish intake, however, hardly attenuated the differences in relative EPA, DHA, DGLA and AA concentrations between the various ethnic groups. Given the limitations of this observational study, further research into the ethnicity-related differences in maternal n-3 and n-6 fatty acid patterns is warranted, particularly to elucidate the explanatory role of fatty acid intake v. metabolic differences.

Authors+Show Affiliations

Department of Epidemiology, Documentation and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands. mveijsden@ggd.amsterdam.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18983717

Citation

van Eijsden, Manon, et al. "Ethnic Differences in Early Pregnancy Maternal N-3 and N-6 Fatty Acid Concentrations: an Explorative Analysis." The British Journal of Nutrition, vol. 101, no. 12, 2009, pp. 1761-8.
van Eijsden M, Hornstra G, van der Wal MF, et al. Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis. Br J Nutr. 2009;101(12):1761-8.
van Eijsden, M., Hornstra, G., van der Wal, M. F., & Bonsel, G. J. (2009). Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis. The British Journal of Nutrition, 101(12), 1761-8. https://doi.org/10.1017/S0007114508123455
van Eijsden M, et al. Ethnic Differences in Early Pregnancy Maternal N-3 and N-6 Fatty Acid Concentrations: an Explorative Analysis. Br J Nutr. 2009;101(12):1761-8. PubMed PMID: 18983717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis. AU - van Eijsden,Manon, AU - Hornstra,Gerard, AU - van der Wal,Marcel F, AU - Bonsel,Gouke J, Y1 - 2008/11/05/ PY - 2008/11/6/pubmed PY - 2009/9/4/medline PY - 2008/11/6/entrez SP - 1761 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 101 IS - 12 N2 - Ethnicity-related differences in maternal n-3 and n-6 fatty acid status may be relevant to ethnic disparities in birth outcomes observed worldwide. The present study explored differences in early pregnancy n-3 and n-6 fatty acid composition of maternal plasma phospholipids between Dutch and ethnic minority pregnant women in Amsterdam, the Netherlands, with a focus on the major functional fatty acids EPA (20 : 5n-3), DHA (22 : 6n-3), dihomo-gamma-linolenic acid (DGLA; 20 : 3n-6) and arachidonic acid (AA; 20 : 4n-6). Data were derived from the Amsterdam Born Children and their Development (ABCD) cohort (inclusion January 2003 to March 2004). Compared with Dutch women (n 2443), Surinamese (n 286), Antillean (n 63), Turkish (n 167) and Moroccan (n 241) women had generally lower proportions of n-3 fatty acids (expressed as percentage of total fatty acids) but higher proportions of n-6 fatty acids (general linear model; P < 0.001). Ghanaian women (n 54) had higher proportions of EPA and DHA, but generally lower proportions of n-6 fatty acids (P < 0.001). Differences were most pronounced in Turkish and Ghanaian women, who, by means of a simple questionnaire, reported the lowest and highest fish consumption respectively. Adjustment for fish intake, however, hardly attenuated the differences in relative EPA, DHA, DGLA and AA concentrations between the various ethnic groups. Given the limitations of this observational study, further research into the ethnicity-related differences in maternal n-3 and n-6 fatty acid patterns is warranted, particularly to elucidate the explanatory role of fatty acid intake v. metabolic differences. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18983717/Ethnic_differences_in_early_pregnancy_maternal_n_3_and_n_6_fatty_acid_concentrations:_an_explorative_analysis_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508123455/type/journal_article DB - PRIME DP - Unbound Medicine ER -