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Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus.
Toxicon. 2008 Dec 15; 52(8):842-51.T

Abstract

The genus Bothrops spp. is responsible for 90% of envenomation by snakes in Brazil, and the standard treatment for snakebites is the antivenom therapy. The anti-bothropic serum produced by Butantan Institute is prepared by the hyperimmunization of horses with a pool of venoms from Bothrops alternatus, Bothrops jararaca, Bothrops jararacussu, Bothrops moojeni and Bothrops neuwiedi. In this study, the biochemical and biological characteristics of the venoms from nineteen snakes of the genus Bothrops, responsible for human accidents in Brazil, were analysed. Venoms, particularly from Crotalidae and Viperidae snakes, are rich sources of serine proteases and metalloproteases and the ability of the Brazilian anti-bothropic serum to neutralize the proteolytic activity of these venoms were also tested. The results obtained here show the existence of a large range of variation in the composition and activities in Bothrops spp. toxins and demonstrate that the anti-bothropic serum is not able to fully neutralize the toxic activities of all analysed venoms. These suggest that for the preparation of a fully effective therapeutic anti-bothropic serum, other venoms should be included in the immunization mixture.

Authors+Show Affiliations

Immunochemistry Laboratory, Butantan Institute, Av. Prof. Vital Brazil, 1500, CEP 05503-900, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18983867

Citation

Queiroz, Giselle Pidde, et al. "Interspecific Variation in Venom Composition and Toxicity of Brazilian Snakes From Bothrops Genus." Toxicon : Official Journal of the International Society On Toxinology, vol. 52, no. 8, 2008, pp. 842-51.
Queiroz GP, Pessoa LA, Portaro FC, et al. Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. Toxicon. 2008;52(8):842-51.
Queiroz, G. P., Pessoa, L. A., Portaro, F. C., Furtado, M. d. e. . F., & Tambourgi, D. V. (2008). Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. Toxicon : Official Journal of the International Society On Toxinology, 52(8), 842-51. https://doi.org/10.1016/j.toxicon.2008.10.002
Queiroz GP, et al. Interspecific Variation in Venom Composition and Toxicity of Brazilian Snakes From Bothrops Genus. Toxicon. 2008 Dec 15;52(8):842-51. PubMed PMID: 18983867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. AU - Queiroz,Giselle Pidde, AU - Pessoa,Lucas Alves, AU - Portaro,Fernanda C V, AU - Furtado,Maria de Fátima D, AU - Tambourgi,Denise V, Y1 - 2008/10/17/ PY - 2008/04/18/received PY - 2008/09/05/revised PY - 2008/10/07/accepted PY - 2008/11/6/pubmed PY - 2009/3/13/medline PY - 2008/11/6/entrez SP - 842 EP - 51 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 52 IS - 8 N2 - The genus Bothrops spp. is responsible for 90% of envenomation by snakes in Brazil, and the standard treatment for snakebites is the antivenom therapy. The anti-bothropic serum produced by Butantan Institute is prepared by the hyperimmunization of horses with a pool of venoms from Bothrops alternatus, Bothrops jararaca, Bothrops jararacussu, Bothrops moojeni and Bothrops neuwiedi. In this study, the biochemical and biological characteristics of the venoms from nineteen snakes of the genus Bothrops, responsible for human accidents in Brazil, were analysed. Venoms, particularly from Crotalidae and Viperidae snakes, are rich sources of serine proteases and metalloproteases and the ability of the Brazilian anti-bothropic serum to neutralize the proteolytic activity of these venoms were also tested. The results obtained here show the existence of a large range of variation in the composition and activities in Bothrops spp. toxins and demonstrate that the anti-bothropic serum is not able to fully neutralize the toxic activities of all analysed venoms. These suggest that for the preparation of a fully effective therapeutic anti-bothropic serum, other venoms should be included in the immunization mixture. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/18983867/Interspecific_variation_in_venom_composition_and_toxicity_of_Brazilian_snakes_from_Bothrops_genus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(08)00545-X DB - PRIME DP - Unbound Medicine ER -