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Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks.
Behav Brain Res. 2009 Feb 11; 197(2):388-97.BB

Abstract

The present study was designed to determine the degree of functional dissociation between the rat perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. In one experiment, 30 rats were trained on a two-pair concurrent object discrimination task in an elevated radial arm maze. Rats with a perirhinal cortex lesion needed significantly more days to attain the criterion in the relearning of a pre-operatively acquired object discrimination task than the control rats and rats with a hippocampal lesion. However, there were no significant differences between the three groups in the days to attain the criterion in learning post-operatively the original object discrimination task with new discriminanda and its relearning. The rats with a hippocampal lesion did not show any impairment in object discrimination. In a second experiment, 27 rats were trained on a place discrimination task in the same maze. Rats with a hippocampal lesion required more days to attain the criterion than the control rats to relearn the pre-operatively acquired place discrimination task, and they had fewer correct responses in the first three sessions with new discriminanda than the control rats. Rats with a perirhinal cortex lesion, on the other hand, showed mild relearning impairment. These results suggest that there is a functionally single dissociation between the perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. They also suggest the possible involvement of the perirhinal cortex in spatial reference memory performance.

Authors+Show Affiliations

Division of Psychiatry, Department of Clinical Neuroscience, School of Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. abehiro@med.miyazaki-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18984009

Citation

Abe, Hiroshi, et al. "Functional Difference Between Rat Perirhinal Cortex and Hippocampus in Object and Place Discrimination Tasks." Behavioural Brain Research, vol. 197, no. 2, 2009, pp. 388-97.
Abe H, Ishida Y, Nonaka H, et al. Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks. Behav Brain Res. 2009;197(2):388-97.
Abe, H., Ishida, Y., Nonaka, H., & Iwasaki, T. (2009). Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks. Behavioural Brain Research, 197(2), 388-97. https://doi.org/10.1016/j.bbr.2008.10.012
Abe H, et al. Functional Difference Between Rat Perirhinal Cortex and Hippocampus in Object and Place Discrimination Tasks. Behav Brain Res. 2009 Feb 11;197(2):388-97. PubMed PMID: 18984009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks. AU - Abe,Hiroshi, AU - Ishida,Yasushi, AU - Nonaka,Hiroi, AU - Iwasaki,Tsuneo, Y1 - 2008/10/15/ PY - 2008/01/14/received PY - 2008/09/29/revised PY - 2008/10/04/accepted PY - 2008/11/6/pubmed PY - 2009/2/24/medline PY - 2008/11/6/entrez SP - 388 EP - 97 JF - Behavioural brain research JO - Behav Brain Res VL - 197 IS - 2 N2 - The present study was designed to determine the degree of functional dissociation between the rat perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. In one experiment, 30 rats were trained on a two-pair concurrent object discrimination task in an elevated radial arm maze. Rats with a perirhinal cortex lesion needed significantly more days to attain the criterion in the relearning of a pre-operatively acquired object discrimination task than the control rats and rats with a hippocampal lesion. However, there were no significant differences between the three groups in the days to attain the criterion in learning post-operatively the original object discrimination task with new discriminanda and its relearning. The rats with a hippocampal lesion did not show any impairment in object discrimination. In a second experiment, 27 rats were trained on a place discrimination task in the same maze. Rats with a hippocampal lesion required more days to attain the criterion than the control rats to relearn the pre-operatively acquired place discrimination task, and they had fewer correct responses in the first three sessions with new discriminanda than the control rats. Rats with a perirhinal cortex lesion, on the other hand, showed mild relearning impairment. These results suggest that there is a functionally single dissociation between the perirhinal cortex and hippocampus for reference memory performance on object and place discrimination tasks. They also suggest the possible involvement of the perirhinal cortex in spatial reference memory performance. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/18984009/Functional_difference_between_rat_perirhinal_cortex_and_hippocampus_in_object_and_place_discrimination_tasks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00556-1 DB - PRIME DP - Unbound Medicine ER -