Tags

Type your tag names separated by a space and hit enter

The effect of caffeine on postprandial hypotension in the elderly.
J Am Geriatr Soc. 1991 Feb; 39(2):160-4.JA

Abstract

In a double-blind, randomized trial the effects of caffeinated and decaffeinated drinks on postprandial hemodynamic and neurohumoral changes were studied in seven fit, elderly subjects after a standard 2.4MJ meal. There was a significant difference in supine postprandial systolic blood pressure between the placebo and caffeine phases (P less than 0.01); at 60 minutes, supine systolic blood pressure had fallen 14 mmHg [95% confidence interval (CI)-7 to-21 mmHg, p less than 0.01) after placebo, but was unchanged after caffeine (+9 mmHg, CI 0 to 18 mmHg, NS]. Similar differences between placebo and caffeine were seen in erect systolic and diastolic blood pressure (P less than 0.01), although orthostatic tolerance was maintained throughout each study period. Postprandial plasma noradrenaline levels were higher (P less than 0.02) and the increase greater (P less than 0.02) after caffeine than after placebo. Caffeine administered at the end of a standard test meal prevents the postprandial fall in blood pressure in fit, elderly subjects. The clinical relevance of this finding has yet to be determined, but it may offer a simple remedy for patients with symptomatic postprandial hypotension.

Authors+Show Affiliations

Department of Geriatric Medicine, Kingston General Hospital, Hull, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1898434

Citation

Heseltine, D, et al. "The Effect of Caffeine On Postprandial Hypotension in the Elderly." Journal of the American Geriatrics Society, vol. 39, no. 2, 1991, pp. 160-4.
Heseltine D, Dakkak M, Woodhouse K, et al. The effect of caffeine on postprandial hypotension in the elderly. J Am Geriatr Soc. 1991;39(2):160-4.
Heseltine, D., Dakkak, M., Woodhouse, K., Macdonald, I. A., & Potter, J. F. (1991). The effect of caffeine on postprandial hypotension in the elderly. Journal of the American Geriatrics Society, 39(2), 160-4.
Heseltine D, et al. The Effect of Caffeine On Postprandial Hypotension in the Elderly. J Am Geriatr Soc. 1991;39(2):160-4. PubMed PMID: 1898434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of caffeine on postprandial hypotension in the elderly. AU - Heseltine,D, AU - Dakkak,M, AU - Woodhouse,K, AU - Macdonald,I A, AU - Potter,J F, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 160 EP - 4 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 39 IS - 2 N2 - In a double-blind, randomized trial the effects of caffeinated and decaffeinated drinks on postprandial hemodynamic and neurohumoral changes were studied in seven fit, elderly subjects after a standard 2.4MJ meal. There was a significant difference in supine postprandial systolic blood pressure between the placebo and caffeine phases (P less than 0.01); at 60 minutes, supine systolic blood pressure had fallen 14 mmHg [95% confidence interval (CI)-7 to-21 mmHg, p less than 0.01) after placebo, but was unchanged after caffeine (+9 mmHg, CI 0 to 18 mmHg, NS]. Similar differences between placebo and caffeine were seen in erect systolic and diastolic blood pressure (P less than 0.01), although orthostatic tolerance was maintained throughout each study period. Postprandial plasma noradrenaline levels were higher (P less than 0.02) and the increase greater (P less than 0.02) after caffeine than after placebo. Caffeine administered at the end of a standard test meal prevents the postprandial fall in blood pressure in fit, elderly subjects. The clinical relevance of this finding has yet to be determined, but it may offer a simple remedy for patients with symptomatic postprandial hypotension. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/1898434/The_effect_of_caffeine_on_postprandial_hypotension_in_the_elderly_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=1991&volume=39&issue=2&spage=160 DB - PRIME DP - Unbound Medicine ER -