Tags

Type your tag names separated by a space and hit enter

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial.
JAMA 2008; 300(17):2012-21JAMA

Abstract

CONTEXT

Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention.

OBJECTIVE

To evaluate the effect of combined folic acid, vitamin B(6), and vitamin B(12) treatment on cancer risk in women at high risk for cardiovascular disease.

DESIGN, SETTING, AND PARTICIPANTS

In the Women's Antioxidant and Folic Acid Cardiovascular Study, 5442 US female health professionals aged 42 years or older, with preexisting cardiovascular disease or 3 or more coronary risk factors, were randomly assigned to receive either a daily combination of folic acid, vitamin B(6), and vitamin B(12) or a matching placebo. They were treated for 7.3 years from April 1998 through July 31, 2005.

INTERVENTION

Daily supplementation of a combination of 2.5 mg of folic acid, 50 mg of vitamin B(6), and 1 mg of vitamin B(12) (n = 2721) or placebo (n = 2721).

MAIN OUTCOME MEASURES

Confirmed newly diagnosed total invasive cancer or breast cancer.

RESULTS

A total of 379 women developed invasive cancer (187 in the active treatment group and 192 in the placebo group). Compared with placebo, women receiving the active treatment had similar risk of developing total invasive cancer (101.1/10,000 person-years for the active treatment group vs 104.3/10,000 person-years for placebo group; hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.79-1.18; P = .75), breast cancer (37.8/10,000 person-years vs 45.6/10,000 person-years, respectively; HR, 0.83; 95% CI, 0.60-1.14; P = .24), or any cancer death (24.6/10,000 person-years vs 30.1/10,000 person-years, respectively; HR, 0.82; 95% CI, 0.56-1.21; P = .32).

CONCLUSION

Combined folic acid, vitamin B(6), and vitamin B(12) treatment had no significant effect on overall risk of total invasive cancer or breast cancer among women during the folic acid fortification era.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00000541.

Authors+Show Affiliations

Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. szhang@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18984888

Citation

Zhang, Shumin M., et al. "Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12 On Cancer Risk in Women: a Randomized Trial." JAMA, vol. 300, no. 17, 2008, pp. 2012-21.
Zhang SM, Cook NR, Albert CM, et al. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA. 2008;300(17):2012-21.
Zhang, S. M., Cook, N. R., Albert, C. M., Gaziano, J. M., Buring, J. E., & Manson, J. E. (2008). Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA, 300(17), pp. 2012-21. doi:10.1001/jama.2008.555.
Zhang SM, et al. Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12 On Cancer Risk in Women: a Randomized Trial. JAMA. 2008 Nov 5;300(17):2012-21. PubMed PMID: 18984888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. AU - Zhang,Shumin M, AU - Cook,Nancy R, AU - Albert,Christine M, AU - Gaziano,J Michael, AU - Buring,Julie E, AU - Manson,Joann E, PY - 2008/11/6/pubmed PY - 2008/11/11/medline PY - 2008/11/6/entrez SP - 2012 EP - 21 JF - JAMA JO - JAMA VL - 300 IS - 17 N2 - CONTEXT: Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention. OBJECTIVE: To evaluate the effect of combined folic acid, vitamin B(6), and vitamin B(12) treatment on cancer risk in women at high risk for cardiovascular disease. DESIGN, SETTING, AND PARTICIPANTS: In the Women's Antioxidant and Folic Acid Cardiovascular Study, 5442 US female health professionals aged 42 years or older, with preexisting cardiovascular disease or 3 or more coronary risk factors, were randomly assigned to receive either a daily combination of folic acid, vitamin B(6), and vitamin B(12) or a matching placebo. They were treated for 7.3 years from April 1998 through July 31, 2005. INTERVENTION: Daily supplementation of a combination of 2.5 mg of folic acid, 50 mg of vitamin B(6), and 1 mg of vitamin B(12) (n = 2721) or placebo (n = 2721). MAIN OUTCOME MEASURES: Confirmed newly diagnosed total invasive cancer or breast cancer. RESULTS: A total of 379 women developed invasive cancer (187 in the active treatment group and 192 in the placebo group). Compared with placebo, women receiving the active treatment had similar risk of developing total invasive cancer (101.1/10,000 person-years for the active treatment group vs 104.3/10,000 person-years for placebo group; hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.79-1.18; P = .75), breast cancer (37.8/10,000 person-years vs 45.6/10,000 person-years, respectively; HR, 0.83; 95% CI, 0.60-1.14; P = .24), or any cancer death (24.6/10,000 person-years vs 30.1/10,000 person-years, respectively; HR, 0.82; 95% CI, 0.56-1.21; P = .32). CONCLUSION: Combined folic acid, vitamin B(6), and vitamin B(12) treatment had no significant effect on overall risk of total invasive cancer or breast cancer among women during the folic acid fortification era. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000541. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/18984888/Effect_of_combined_folic_acid_vitamin_B6_and_vitamin_B12_on_cancer_risk_in_women:_a_randomized_trial_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2008.555 DB - PRIME DP - Unbound Medicine ER -