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Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas.
ORL J Otorhinolaryngol Relat Spec. 2008; 70(6):344-51.OJ

Abstract

BACKGROUND/AIMS

The role of postoperative radiotherapy (PORT) in head and neck mucosal melanomas (HNMM) is not yet clearly defined. The aim of this study is to report the 21-year experience of the Brazilian National Cancer Institute in such treatment.

METHODS

From January 1983 to December 2003, 31 patients with confirmed histological diagnosis of HNMM underwent treatment at the Brazilian National Cancer Institute. Of these, 20 received radical treatment with surgery alone (8 patients--group 1) or surgery and PORT (12 patients--group 2).

RESULTS

Local control and the median time to local failure at 5 years were 75% and 14 months for group 1 and 83.5% and 40 months for group 2 (p = 0.06). The overall survival rates at 3 years were 37.5% for group 1 and 58% for group 2. At 5 years the survival rates were 25% for both groups (p = NS). When PORT was initiated within 60 days after surgery, there was a trend towards improvement in overall survival (p = 0.08). After univariate analysis, distant metastasis, location of primary disease and tobacco smoking were important prognostic factors.

CONCLUSION

Early (<60 days) PORT for HNMM provides better local control with a longer disease-free survival.

Authors+Show Affiliations

Department of Radiation Oncology, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18984969

Citation

Nakashima, Juliano P., et al. "Postoperative Adjuvant Radiation Therapy in the Treatment of Primary Head and Neck Mucosal Melanomas." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 70, no. 6, 2008, pp. 344-51.
Nakashima JP, Viégas CM, Fassizoli AL, et al. Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas. ORL J Otorhinolaryngol Relat Spec. 2008;70(6):344-51.
Nakashima, J. P., Viégas, C. M., Fassizoli, A. L., Rodrigues, M., Chamon, L. A., Silva, J. H., Dias, F. L., & Araújo, C. M. (2008). Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 70(6), 344-51. https://doi.org/10.1159/000163029
Nakashima JP, et al. Postoperative Adjuvant Radiation Therapy in the Treatment of Primary Head and Neck Mucosal Melanomas. ORL J Otorhinolaryngol Relat Spec. 2008;70(6):344-51. PubMed PMID: 18984969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas. AU - Nakashima,Juliano P, AU - Viégas,Célia M, AU - Fassizoli,Ana L, AU - Rodrigues,Marcelo, AU - Chamon,Leonardo A G, AU - Silva,João H C, AU - Dias,Fernando L, AU - Araújo,Carlos M, Y1 - 2008/11/04/ PY - 2007/07/10/received PY - 2007/10/17/accepted PY - 2008/11/6/pubmed PY - 2009/2/12/medline PY - 2008/11/6/entrez SP - 344 EP - 51 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J Otorhinolaryngol Relat Spec VL - 70 IS - 6 N2 - BACKGROUND/AIMS: The role of postoperative radiotherapy (PORT) in head and neck mucosal melanomas (HNMM) is not yet clearly defined. The aim of this study is to report the 21-year experience of the Brazilian National Cancer Institute in such treatment. METHODS: From January 1983 to December 2003, 31 patients with confirmed histological diagnosis of HNMM underwent treatment at the Brazilian National Cancer Institute. Of these, 20 received radical treatment with surgery alone (8 patients--group 1) or surgery and PORT (12 patients--group 2). RESULTS: Local control and the median time to local failure at 5 years were 75% and 14 months for group 1 and 83.5% and 40 months for group 2 (p = 0.06). The overall survival rates at 3 years were 37.5% for group 1 and 58% for group 2. At 5 years the survival rates were 25% for both groups (p = NS). When PORT was initiated within 60 days after surgery, there was a trend towards improvement in overall survival (p = 0.08). After univariate analysis, distant metastasis, location of primary disease and tobacco smoking were important prognostic factors. CONCLUSION: Early (<60 days) PORT for HNMM provides better local control with a longer disease-free survival. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/18984969/Postoperative_adjuvant_radiation_therapy_in_the_treatment_of_primary_head_and_neck_mucosal_melanomas_ L2 - https://www.karger.com?DOI=10.1159/000163029 DB - PRIME DP - Unbound Medicine ER -