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Serum and middle ear immunoglobulins in suppurative otitis media.

Abstract

BACKGROUND AND PURPOSE

Despite the increasing occurrence of suppurative otitis media (SOM), the content of immunoglobulin fractions in the middle ear secretion (MES) has still not been determined.

METHOD

The serum and MESwere analyzed for IgG and M using enzyme-linked immunoassay.

RESULT

The subjects and controls were 30 males and 22 females, between 6 months and 9 years old, with a mean age of 6 years (SD = 3.26). The patient group included 20 chronic SOM (CSOM) and 17 acute SOM (ASOM) cases, and sera of 15 subjects made the control group. The mean serum IgG levels were for controls 1,051 mg/dl, ASOM 666.1 mg/dl and CSOM 1,321.1 mg/dl; the MES levels were for ASOM 203.4 mg/dl and CSOM 511.5 mg/dl. The mean serum IgM levels were for controls 35 mg/dl, ASOM 64.1 mg/dl and CSOM 40 mg/dl; the MES levels were for ASOM 22.59 mg/dl and CSOM 3.44 mg/dl. The mean MES:serum ratios for IgG and IgM were between 0.1 and 0.4 in ASOM and CSOM. The ratio of serum IgG levels of controls to ASOM cases was 0.66 while that of controls to CSOM was 1.3. The corresponding ratios of IgM were 1.6 and 0.88. Multivariate analysis revealed a significant correlation between serum IgG levels of ASOM and CSOM (p = 0.043) and MES IgG (p = 0.02) in ASOM and CSOM but no correlation between serum IgG levels in controls and ASOM (p = 0.25), serum IgM levels in controls and CSOM (p = 0.62) and serum IgM levels in controls and ASOM (p = 0.73), ASOM and CSOM (p = 0.064) and MES IgM levels of ASOM and CSOM (p = 0.06).

CONCLUSIONS

Monitoring of the serum and MES IgG in ASOM may provide a useful index to assess the possibility of progression to chronicity. This forms a database for the immunological status of SOM patients.

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  • Authors+Show Affiliations

    ,

    Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria. akeemlasisi@gmail.com

    ,

    Source

    MeSH

    Acute Disease
    Analysis of Variance
    Biomarkers
    Case-Control Studies
    Child
    Child, Preschool
    Chronic Disease
    Disease Progression
    Ear, Middle
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Immunoglobulin G
    Immunoglobulin M
    Immunoglobulins
    Infant
    Male
    Monitoring, Physiologic
    Otitis Media, Suppurative
    Probability
    Prognosis
    Reference Values
    Risk Assessment
    Sensitivity and Specificity
    Severity of Illness Index

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    18984975

    Citation

    Lasisi, Akeem O., et al. "Serum and Middle Ear Immunoglobulins in Suppurative Otitis Media." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 70, no. 6, 2008, pp. 389-92.
    Lasisi AO, Arinola OG, Bakare RA. Serum and middle ear immunoglobulins in suppurative otitis media. ORL J Otorhinolaryngol Relat Spec. 2008;70(6):389-92.
    Lasisi, A. O., Arinola, O. G., & Bakare, R. A. (2008). Serum and middle ear immunoglobulins in suppurative otitis media. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 70(6), pp. 389-92. doi:10.1159/000163035.
    Lasisi AO, Arinola OG, Bakare RA. Serum and Middle Ear Immunoglobulins in Suppurative Otitis Media. ORL J Otorhinolaryngol Relat Spec. 2008;70(6):389-92. PubMed PMID: 18984975.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum and middle ear immunoglobulins in suppurative otitis media. AU - Lasisi,Akeem O, AU - Arinola,Olatubosun G, AU - Bakare,Rasheed A, Y1 - 2008/11/04/ PY - 2007/09/06/received PY - 2008/03/11/accepted PY - 2008/11/6/pubmed PY - 2009/2/12/medline PY - 2008/11/6/entrez SP - 389 EP - 92 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 70 IS - 6 N2 - BACKGROUND AND PURPOSE: Despite the increasing occurrence of suppurative otitis media (SOM), the content of immunoglobulin fractions in the middle ear secretion (MES) has still not been determined. METHOD: The serum and MESwere analyzed for IgG and M using enzyme-linked immunoassay. RESULT: The subjects and controls were 30 males and 22 females, between 6 months and 9 years old, with a mean age of 6 years (SD = 3.26). The patient group included 20 chronic SOM (CSOM) and 17 acute SOM (ASOM) cases, and sera of 15 subjects made the control group. The mean serum IgG levels were for controls 1,051 mg/dl, ASOM 666.1 mg/dl and CSOM 1,321.1 mg/dl; the MES levels were for ASOM 203.4 mg/dl and CSOM 511.5 mg/dl. The mean serum IgM levels were for controls 35 mg/dl, ASOM 64.1 mg/dl and CSOM 40 mg/dl; the MES levels were for ASOM 22.59 mg/dl and CSOM 3.44 mg/dl. The mean MES:serum ratios for IgG and IgM were between 0.1 and 0.4 in ASOM and CSOM. The ratio of serum IgG levels of controls to ASOM cases was 0.66 while that of controls to CSOM was 1.3. The corresponding ratios of IgM were 1.6 and 0.88. Multivariate analysis revealed a significant correlation between serum IgG levels of ASOM and CSOM (p = 0.043) and MES IgG (p = 0.02) in ASOM and CSOM but no correlation between serum IgG levels in controls and ASOM (p = 0.25), serum IgM levels in controls and CSOM (p = 0.62) and serum IgM levels in controls and ASOM (p = 0.73), ASOM and CSOM (p = 0.064) and MES IgM levels of ASOM and CSOM (p = 0.06). CONCLUSIONS: Monitoring of the serum and MES IgG in ASOM may provide a useful index to assess the possibility of progression to chronicity. This forms a database for the immunological status of SOM patients. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/18984975/Serum_and_middle_ear_immunoglobulins_in_suppurative_otitis_media_ L2 - https://www.karger.com?DOI=10.1159/000163035 DB - PRIME DP - Unbound Medicine ER -