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Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity.
J Asian Nat Prod Res. 2008 Sep-Oct; 10(9-10):873-80.JA

Abstract

Four new oleanane-type triterpenoid saponins, cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (1), cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-glucopyranosyl-(1 --> 3)-beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (2), cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-6-O-acetylglucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (3) and 3beta-O-[alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside]-16,28-dihydroxy-30-acetoxyoleana-12-en (4), along with one known triterpene saponin and ardisiacrispin A (5) were isolated from the rhizome of Ardisia gigantifolia. Their structures were established with the help of extensive spectroscopic techniques. Furthermore, the inhibitory effects of compounds on tumor cells (MTT based) in vitro were evaluated, and compounds 1, 2, and 5 showed potent anti-tumor activities.

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Authors+Show Affiliations

Wen P
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Zhang XM
No affiliation info available
Yang Z
No affiliation info available
Wang NL
No affiliation info available
Yao XS
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicArdisiaCell Line, TumorHumansMiceMolecular StructureRhizomeSaponinsTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18985500

Citation

Wen, Ping, et al. "Four New Triterpenoid Saponins From Ardisia Gigantifolia Stapf. and Their Cytotoxic Activity." Journal of Asian Natural Products Research, vol. 10, no. 9-10, 2008, pp. 873-80.
Wen P, Zhang XM, Yang Z, et al. Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity. J Asian Nat Prod Res. 2008;10(9-10):873-80.
Wen, P., Zhang, X. M., Yang, Z., Wang, N. L., & Yao, X. S. (2008). Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity. Journal of Asian Natural Products Research, 10(9-10), 873-80. https://doi.org/10.1080/10286020802144719
Wen P, et al. Four New Triterpenoid Saponins From Ardisia Gigantifolia Stapf. and Their Cytotoxic Activity. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):873-80. PubMed PMID: 18985500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity. AU - Wen,Ping, AU - Zhang,Xiao-Ming, AU - Yang,Zhu, AU - Wang,Nai-Li, AU - Yao,Xin-Sheng, PY - 2008/11/6/pubmed PY - 2009/3/25/medline PY - 2008/11/6/entrez SP - 873 EP - 80 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 10 IS - 9-10 N2 - Four new oleanane-type triterpenoid saponins, cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (1), cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-glucopyranosyl-(1 --> 3)-beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (2), cyclamiretin A 3beta-O-alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-6-O-acetylglucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside (3) and 3beta-O-[alpha-L-rhamnopyranosyl-(1 --> 3)-[beta-D-xylopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranoside]-16,28-dihydroxy-30-acetoxyoleana-12-en (4), along with one known triterpene saponin and ardisiacrispin A (5) were isolated from the rhizome of Ardisia gigantifolia. Their structures were established with the help of extensive spectroscopic techniques. Furthermore, the inhibitory effects of compounds on tumor cells (MTT based) in vitro were evaluated, and compounds 1, 2, and 5 showed potent anti-tumor activities. SN - 1028-6020 UR - https://www.unboundmedicine.com/medline/citation/18985500/Four_new_triterpenoid_saponins_from_Ardisia_gigantifolia_Stapf__and_their_cytotoxic_activity_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020802144719 DB - PRIME DP - Unbound Medicine ER -