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Cardiovascular risk and prevalence of metabolic syndrome by differing criteria.
Chin Med J (Engl). 2008 Aug 20; 121(16):1532-6.CM

Abstract

BACKGROUND

The prevalence of metabolic syndrome (MetS) in hypertensive population in Chinese countryside is unknown. Firstly, this study compared the prevalence of MetS according to National Cholesterol Education Program (NCEP) ATPIII, revised NCEP and International Diabetes Federation (IDF) definitions. Secondly, it investigated the association between MetS, coronary heart disease (CHD) and stroke in patients with hypertension.

METHODS

In this cross sectional study, the cluster sampling method was used. Three MetS definitions were applied to 1418 normal subjects and 5348 hypertensive patients aged 40-75 years in rural areas in China. The agreement between different MetS definitions was estimated by kappa statistics. Logistic regression analyses determined the association between MetS defined by the three MetS definitions and CHD and stroke.

RESULTS

In subjects without hypertension, the prevalence of Mets was 4.1% by NCEP definition, 8.3% revised NCEP definition and 7.8% IDF definition. In hypertensive individuals, the prevalence was 14.0%, 32.9%, and 27.4% in men; 35.6%, 53.1%, and 50.2% in women by the same definitions, respectively. In hypertensive individuals, the agreement was 94.4% in men and 97.0% in women between revised NCEP and IDF definitions. The IDF defined MetS was more strongly associated with CHD than the NCEP or revised NCEP defined MetS (adjusted odds ratio: 1.92 compared with 1.85 and 1.69 in men; 1.64 compared with 1.48 and 1.60 in women).

CONCLUSIONS

In the patients with hypertension, the revised NCEP and IDF definitions identified more individuals than NCEP definition and their agreement is very high. The IDF defined MetS is more strongly associated with CHD than the NCEP or revised NCEP defined MetS, but weakly or not associated with stroke.

Authors+Show Affiliations

Hypertension Div., Fuwai Hospital and Cardiovascular Inst., Key Lab. of Clinical Cardiovascular Genetics, Ministry of Educ., Sino-German Lab. for Molecular Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18985935

Citation

Li, Wei-ju, et al. "Cardiovascular Risk and Prevalence of Metabolic Syndrome By Differing Criteria." Chinese Medical Journal, vol. 121, no. 16, 2008, pp. 1532-6.
Li WJ, Xue H, Sun K, et al. Cardiovascular risk and prevalence of metabolic syndrome by differing criteria. Chin Med J. 2008;121(16):1532-6.
Li, W. J., Xue, H., Sun, K., Song, X. D., Wang, Y. B., Zhen, Y. S., Han, Y. F., & Hui, R. T. (2008). Cardiovascular risk and prevalence of metabolic syndrome by differing criteria. Chinese Medical Journal, 121(16), 1532-6.
Li WJ, et al. Cardiovascular Risk and Prevalence of Metabolic Syndrome By Differing Criteria. Chin Med J. 2008 Aug 20;121(16):1532-6. PubMed PMID: 18985935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk and prevalence of metabolic syndrome by differing criteria. AU - Li,Wei-ju, AU - Xue,Hao, AU - Sun,Kai, AU - Song,Xiao-dong, AU - Wang,Yi-bo, AU - Zhen,Yi-song, AU - Han,Yun-feng, AU - Hui,Ru-tai, PY - 2008/11/7/pubmed PY - 2008/12/17/medline PY - 2008/11/7/entrez SP - 1532 EP - 6 JF - Chinese medical journal JO - Chin. Med. J. VL - 121 IS - 16 N2 - BACKGROUND: The prevalence of metabolic syndrome (MetS) in hypertensive population in Chinese countryside is unknown. Firstly, this study compared the prevalence of MetS according to National Cholesterol Education Program (NCEP) ATPIII, revised NCEP and International Diabetes Federation (IDF) definitions. Secondly, it investigated the association between MetS, coronary heart disease (CHD) and stroke in patients with hypertension. METHODS: In this cross sectional study, the cluster sampling method was used. Three MetS definitions were applied to 1418 normal subjects and 5348 hypertensive patients aged 40-75 years in rural areas in China. The agreement between different MetS definitions was estimated by kappa statistics. Logistic regression analyses determined the association between MetS defined by the three MetS definitions and CHD and stroke. RESULTS: In subjects without hypertension, the prevalence of Mets was 4.1% by NCEP definition, 8.3% revised NCEP definition and 7.8% IDF definition. In hypertensive individuals, the prevalence was 14.0%, 32.9%, and 27.4% in men; 35.6%, 53.1%, and 50.2% in women by the same definitions, respectively. In hypertensive individuals, the agreement was 94.4% in men and 97.0% in women between revised NCEP and IDF definitions. The IDF defined MetS was more strongly associated with CHD than the NCEP or revised NCEP defined MetS (adjusted odds ratio: 1.92 compared with 1.85 and 1.69 in men; 1.64 compared with 1.48 and 1.60 in women). CONCLUSIONS: In the patients with hypertension, the revised NCEP and IDF definitions identified more individuals than NCEP definition and their agreement is very high. The IDF defined MetS is more strongly associated with CHD than the NCEP or revised NCEP defined MetS, but weakly or not associated with stroke. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/18985935/Cardiovascular_risk_and_prevalence_of_metabolic_syndrome_by_differing_criteria_ L2 - http://Insights.ovid.com/pubmed?pmid=18985935 DB - PRIME DP - Unbound Medicine ER -