Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6441-3.BM
Abstract
A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed.
Links
MeSH
Pub Type(s)
Journal Article
Language
eng
PubMed ID
18986807
Citation
Li, Mingzong, et al. "Semi-synthesis and Biological Activity of Gamma-lactones Analogs of Camptothecin." Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 24, 2008, pp. 6441-3.
Li M, Tang W, Zeng F, et al. Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorg Med Chem Lett. 2008;18(24):6441-3.
Li, M., Tang, W., Zeng, F., Lou, L., & You, T. (2008). Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorganic & Medicinal Chemistry Letters, 18(24), 6441-3. https://doi.org/10.1016/j.bmcl.2008.10.074
Li M, et al. Semi-synthesis and Biological Activity of Gamma-lactones Analogs of Camptothecin. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6441-3. PubMed PMID: 18986807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.
AU - Li,Mingzong,
AU - Tang,Weidong,
AU - Zeng,Fuxing,
AU - Lou,Liguang,
AU - You,Tianpa,
Y1 - 2008/10/19/
PY - 2008/08/31/received
PY - 2008/10/13/revised
PY - 2008/10/16/accepted
PY - 2008/11/7/pubmed
PY - 2009/4/30/medline
PY - 2008/11/7/entrez
SP - 6441
EP - 3
JF - Bioorganic & medicinal chemistry letters
JO - Bioorg Med Chem Lett
VL - 18
IS - 24
N2 - A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed.
SN - 1464-3405
UR - https://www.unboundmedicine.com/medline/citation/18986807/Semi_synthesis_and_biological_activity_of_gamma_lactones_analogs_of_camptothecin_
DB - PRIME
DP - Unbound Medicine
ER -