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Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.
Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6441-3.BM

Abstract

A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed.

Authors+Show Affiliations

Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18986807

Citation

Li, Mingzong, et al. "Semi-synthesis and Biological Activity of Gamma-lactones Analogs of Camptothecin." Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 24, 2008, pp. 6441-3.
Li M, Tang W, Zeng F, et al. Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorg Med Chem Lett. 2008;18(24):6441-3.
Li, M., Tang, W., Zeng, F., Lou, L., & You, T. (2008). Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. Bioorganic & Medicinal Chemistry Letters, 18(24), 6441-3. https://doi.org/10.1016/j.bmcl.2008.10.074
Li M, et al. Semi-synthesis and Biological Activity of Gamma-lactones Analogs of Camptothecin. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6441-3. PubMed PMID: 18986807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin. AU - Li,Mingzong, AU - Tang,Weidong, AU - Zeng,Fuxing, AU - Lou,Liguang, AU - You,Tianpa, Y1 - 2008/10/19/ PY - 2008/08/31/received PY - 2008/10/13/revised PY - 2008/10/16/accepted PY - 2008/11/7/pubmed PY - 2009/4/30/medline PY - 2008/11/7/entrez SP - 6441 EP - 3 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 18 IS - 24 N2 - A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/18986807/Semi_synthesis_and_biological_activity_of_gamma_lactones_analogs_of_camptothecin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(08)01272-9 DB - PRIME DP - Unbound Medicine ER -