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Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling.
J Lipid Res 2009; 50 Suppl:S272-6JL

Abstract

The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease. Activation of sphingosine kinases (SphKs) by a variety of agonists increases intracellular S1P, which in turn can be secreted out of the cell and bind to and signal through S1P receptors (S1PRs) in an autocrine and/or paracrine manner. Recent studies suggest that this "inside-out" signaling by S1P may play a role in many human diseases. As the roles of the S1PRs in cell and organismal physiology are discussed elsewhere in this volume, we focus this review mainly on recent reports showing how SphKs are activated and S1P reaches its receptors, the role of SphKs and S1P in regulating sphingolipid homeostasis, and the potential importance of the SphK/S1P axis as a therapeutic target in human diseases.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

18987387

Citation

Maceyka, Michael, et al. "Sphingosine-1-phosphate: the Swiss Army Knife of Sphingolipid Signaling." Journal of Lipid Research, vol. 50 Suppl, 2009, pp. S272-6.
Maceyka M, Milstien S, Spiegel S. Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J Lipid Res. 2009;50 Suppl:S272-6.
Maceyka, M., Milstien, S., & Spiegel, S. (2009). Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. Journal of Lipid Research, 50 Suppl, pp. S272-6. doi:10.1194/jlr.R800065-JLR200.
Maceyka M, Milstien S, Spiegel S. Sphingosine-1-phosphate: the Swiss Army Knife of Sphingolipid Signaling. J Lipid Res. 2009;50 Suppl:S272-6. PubMed PMID: 18987387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. AU - Maceyka,Michael, AU - Milstien,Sheldon, AU - Spiegel,Sarah, Y1 - 2008/11/05/ PY - 2008/11/7/pubmed PY - 2009/6/6/medline PY - 2008/11/7/entrez SP - S272 EP - 6 JF - Journal of lipid research JO - J. Lipid Res. VL - 50 Suppl N2 - The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease. Activation of sphingosine kinases (SphKs) by a variety of agonists increases intracellular S1P, which in turn can be secreted out of the cell and bind to and signal through S1P receptors (S1PRs) in an autocrine and/or paracrine manner. Recent studies suggest that this "inside-out" signaling by S1P may play a role in many human diseases. As the roles of the S1PRs in cell and organismal physiology are discussed elsewhere in this volume, we focus this review mainly on recent reports showing how SphKs are activated and S1P reaches its receptors, the role of SphKs and S1P in regulating sphingolipid homeostasis, and the potential importance of the SphK/S1P axis as a therapeutic target in human diseases. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/18987387/Sphingosine_1_phosphate:_the_Swiss_army_knife_of_sphingolipid_signaling_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=18987387 DB - PRIME DP - Unbound Medicine ER -