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Characterization of chemical constituents in Guan Xin II decoction by liquid chromatography coupled with electrospray ionization-mass spectrometry.
Planta Med. 2008 Nov; 74(14):1720-9.PM

Abstract

Guan Xin II decoction (GX II) is a widely used traditional Chinese medicine (TCM) formula for the treatment of coronary heart diseases. However, the comprehensive chemical analysis of the formulated GX II is not clarified yet. An HPLC-DAD-ESI-MSn method was established to analyze GX II and its five component herbs, respectively. A total of 57 compounds, including phenolic acids, glycosides, flavonoids, and alkaloids were identified or tentatively characterized on the basis of their mass spectra or by comparison with reference standards. This is the first time that the chemical composition of GX II was elucidated by LC/MS. The established method will be used for quality control and pharmacokinetic studies of GX II.

Authors+Show Affiliations

The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18988142

Citation

Qiao, Xue, et al. "Characterization of Chemical Constituents in Guan Xin II Decoction By Liquid Chromatography Coupled With Electrospray Ionization-mass Spectrometry." Planta Medica, vol. 74, no. 14, 2008, pp. 1720-9.
Qiao X, Han J, Xu M, et al. Characterization of chemical constituents in Guan Xin II decoction by liquid chromatography coupled with electrospray ionization-mass spectrometry. Planta Med. 2008;74(14):1720-9.
Qiao, X., Han, J., Xu, M., Zhang, Z. C., Sun, S. F., Li, H. F., Wang, B. R., Ye, M., & Guo, D. A. (2008). Characterization of chemical constituents in Guan Xin II decoction by liquid chromatography coupled with electrospray ionization-mass spectrometry. Planta Medica, 74(14), 1720-9. https://doi.org/10.1055/s-0028-1088312
Qiao X, et al. Characterization of Chemical Constituents in Guan Xin II Decoction By Liquid Chromatography Coupled With Electrospray Ionization-mass Spectrometry. Planta Med. 2008;74(14):1720-9. PubMed PMID: 18988142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of chemical constituents in Guan Xin II decoction by liquid chromatography coupled with electrospray ionization-mass spectrometry. AU - Qiao,Xue, AU - Han,Jian, AU - Xu,Man, AU - Zhang,Zi-chuan, AU - Sun,Shi-feng, AU - Li,Hui-feng, AU - Wang,Bao-rong, AU - Ye,Min, AU - Guo,De-an, Y1 - 2008/11/04/ PY - 2008/11/7/pubmed PY - 2009/1/13/medline PY - 2008/11/7/entrez SP - 1720 EP - 9 JF - Planta medica JO - Planta Med VL - 74 IS - 14 N2 - Guan Xin II decoction (GX II) is a widely used traditional Chinese medicine (TCM) formula for the treatment of coronary heart diseases. However, the comprehensive chemical analysis of the formulated GX II is not clarified yet. An HPLC-DAD-ESI-MSn method was established to analyze GX II and its five component herbs, respectively. A total of 57 compounds, including phenolic acids, glycosides, flavonoids, and alkaloids were identified or tentatively characterized on the basis of their mass spectra or by comparison with reference standards. This is the first time that the chemical composition of GX II was elucidated by LC/MS. The established method will be used for quality control and pharmacokinetic studies of GX II. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/18988142/Characterization_of_chemical_constituents_in_Guan_Xin_II_decoction_by_liquid_chromatography_coupled_with_electrospray_ionization_mass_spectrometry_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1088312 DB - PRIME DP - Unbound Medicine ER -