Tags

Type your tag names separated by a space and hit enter

Investigation of stressful life events in patients with systemic sclerosis.
J Zhejiang Univ Sci B 2008; 9(11):853-6JZ

Abstract

OBJECTIVE

To assess the occurrence of stressful life events in the year before the initiation of systemic sclerosis.

METHODS

A consecutive series of 40 patients with systemic sclerosis (mean age (56.3+/-11.9) years, mean disease duration (4.3+/-3.1) years; 32 females and 8 males), including 28 with diffuse cutaneous scleroderma and 12 with limited cutaneous scleroderma, were evaluated. A control group of 40 healthy subjects free of systemic sclerosis also was included. Socioeconomic status was investigated and Paykel's interview for recent life events (a semi-structured research interview covering 64 life events) was conducted.

RESULTS

Patients with systemic sclerosis showed higher percentages of lower education (72.5%) and working class (82.5%), and reported more stressful life events (P<0.05), such as exits (P<0.05), undesirable events (P<0.01), and uncontrolled events (P<0.001), when compared with the control. More events that had an objective negative impact (P<0.001) were also reported in systemic sclerosis patients than in the control. These results are in accordance with a multifactorial model of pathogenesis in systemic sclerosis.

CONCLUSION

We reported a strong relationship between stressful life events and the initiation of systemic sclerosis. Our findings are consistent with current understanding of the extensive links of behavioral responses to stress with neurophysiological and biochemical processes.

Authors+Show Affiliations

Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. lxling@mail.hz.zj.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18988303

Citation

Chen, Yue, et al. "Investigation of Stressful Life Events in Patients With Systemic Sclerosis." Journal of Zhejiang University. Science. B, vol. 9, no. 11, 2008, pp. 853-6.
Chen Y, Huang JZ, Qiang Y, et al. Investigation of stressful life events in patients with systemic sclerosis. J Zhejiang Univ Sci B. 2008;9(11):853-6.
Chen, Y., Huang, J. Z., Qiang, Y., Wang, J., & Han, M. M. (2008). Investigation of stressful life events in patients with systemic sclerosis. Journal of Zhejiang University. Science. B, 9(11), pp. 853-6. doi:10.1631/jzus.B0820069.
Chen Y, et al. Investigation of Stressful Life Events in Patients With Systemic Sclerosis. J Zhejiang Univ Sci B. 2008;9(11):853-6. PubMed PMID: 18988303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of stressful life events in patients with systemic sclerosis. AU - Chen,Yue, AU - Huang,Ji-Zhong, AU - Qiang,Yu, AU - Wang,Jin, AU - Han,Mao-Mao, PY - 2008/11/7/pubmed PY - 2009/3/6/medline PY - 2008/11/7/entrez SP - 853 EP - 6 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 9 IS - 11 N2 - OBJECTIVE: To assess the occurrence of stressful life events in the year before the initiation of systemic sclerosis. METHODS: A consecutive series of 40 patients with systemic sclerosis (mean age (56.3+/-11.9) years, mean disease duration (4.3+/-3.1) years; 32 females and 8 males), including 28 with diffuse cutaneous scleroderma and 12 with limited cutaneous scleroderma, were evaluated. A control group of 40 healthy subjects free of systemic sclerosis also was included. Socioeconomic status was investigated and Paykel's interview for recent life events (a semi-structured research interview covering 64 life events) was conducted. RESULTS: Patients with systemic sclerosis showed higher percentages of lower education (72.5%) and working class (82.5%), and reported more stressful life events (P<0.05), such as exits (P<0.05), undesirable events (P<0.01), and uncontrolled events (P<0.001), when compared with the control. More events that had an objective negative impact (P<0.001) were also reported in systemic sclerosis patients than in the control. These results are in accordance with a multifactorial model of pathogenesis in systemic sclerosis. CONCLUSION: We reported a strong relationship between stressful life events and the initiation of systemic sclerosis. Our findings are consistent with current understanding of the extensive links of behavioral responses to stress with neurophysiological and biochemical processes. SN - 1673-1581 UR - https://www.unboundmedicine.com/medline/citation/18988303/Investigation_of_stressful_life_events_in_patients_with_systemic_sclerosis_ L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.B0820069 DB - PRIME DP - Unbound Medicine ER -