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[Mitochondrial dysfunction and oxidative damages in the molecular pathology of Parkinson's disease].
Mol Biol (Mosk). 2008 Sep-Oct; 42(5):809-19.MB

Abstract

Parkinson's disease is a complex disease characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. Development of this condition is defined by interaction between the genetic constitution of an organism and environmental factors. The analysis of the genes associated with development of monogenic forms of disease, has allowed pointing out proteasome degradation, the differentiation of dopaminergic neurons, the mitochondrial dysfunction and oxidative damage. In this review a variety of data which indicate on a key role of the mitochondrial dysfunction and oxidative stress in Parkinson's disease pathogenesis will be more detail considered.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

18988530

Citation

Shadrina, M I., and P A. Slominskiĭ. "[Mitochondrial Dysfunction and Oxidative Damages in the Molecular Pathology of Parkinson's Disease]." Molekuliarnaia Biologiia, vol. 42, no. 5, 2008, pp. 809-19.
Shadrina MI, Slominskiĭ PA. [Mitochondrial dysfunction and oxidative damages in the molecular pathology of Parkinson's disease]. Mol Biol (Mosk). 2008;42(5):809-19.
Shadrina, M. I., & Slominskiĭ, P. A. (2008). [Mitochondrial dysfunction and oxidative damages in the molecular pathology of Parkinson's disease]. Molekuliarnaia Biologiia, 42(5), 809-19.
Shadrina MI, Slominskiĭ PA. [Mitochondrial Dysfunction and Oxidative Damages in the Molecular Pathology of Parkinson's Disease]. Mol Biol (Mosk). 2008 Sep-Oct;42(5):809-19. PubMed PMID: 18988530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mitochondrial dysfunction and oxidative damages in the molecular pathology of Parkinson's disease]. AU - Shadrina,M I, AU - Slominskiĭ,P A, PY - 2008/11/8/pubmed PY - 2009/1/23/medline PY - 2008/11/8/entrez SP - 809 EP - 19 JF - Molekuliarnaia biologiia JO - Mol Biol (Mosk) VL - 42 IS - 5 N2 - Parkinson's disease is a complex disease characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. Development of this condition is defined by interaction between the genetic constitution of an organism and environmental factors. The analysis of the genes associated with development of monogenic forms of disease, has allowed pointing out proteasome degradation, the differentiation of dopaminergic neurons, the mitochondrial dysfunction and oxidative damage. In this review a variety of data which indicate on a key role of the mitochondrial dysfunction and oxidative stress in Parkinson's disease pathogenesis will be more detail considered. SN - 0026-8984 UR - https://www.unboundmedicine.com/medline/citation/18988530/[Mitochondrial_dysfunction_and_oxidative_damages_in_the_molecular_pathology_of_Parkinson's_disease]_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18988530.ui DB - PRIME DP - Unbound Medicine ER -