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Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla.

Abstract

Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T(1)-weighted images were acquired from 19 Alzheimer's disease patients [age 76 +/- 6 years, three males, Mini-Mental State Examination 13 +/- 4] and 19 controls (age 74 +/- 5 years, 11 males, Mini-Mental State Examination 29 +/- 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P < 0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P < 0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing.

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  • Authors+Show Affiliations

    ,

    Laboratory of Epidemiology Neuroimaging & Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy. gfrisoni@fatebenefratelli.it

    , , , , , , , ,

    Source

    Brain : a journal of neurology 131:Pt 12 2008 Dec pg 3266-76

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Brain Mapping
    Female
    Hippocampus
    Humans
    Image Interpretation, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Psychiatric Status Rating Scales

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18988639

    Citation

    Frisoni, Giovanni B., et al. "Mapping Local Hippocampal Changes in Alzheimer's Disease and Normal Ageing With MRI at 3 Tesla." Brain : a Journal of Neurology, vol. 131, no. Pt 12, 2008, pp. 3266-76.
    Frisoni GB, Ganzola R, Canu E, et al. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla. Brain. 2008;131(Pt 12):3266-76.
    Frisoni, G. B., Ganzola, R., Canu, E., Rüb, U., Pizzini, F. B., Alessandrini, F., ... Thompson, P. M. (2008). Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla. Brain : a Journal of Neurology, 131(Pt 12), pp. 3266-76. doi:10.1093/brain/awn280.
    Frisoni GB, et al. Mapping Local Hippocampal Changes in Alzheimer's Disease and Normal Ageing With MRI at 3 Tesla. Brain. 2008;131(Pt 12):3266-76. PubMed PMID: 18988639.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla. AU - Frisoni,Giovanni B, AU - Ganzola,Rossana, AU - Canu,Elisa, AU - Rüb,Udo, AU - Pizzini,Francesca B, AU - Alessandrini,Franco, AU - Zoccatelli,Giada, AU - Beltramello,Alberto, AU - Caltagirone,Carlo, AU - Thompson,Paul M, Y1 - 2008/11/06/ PY - 2008/11/8/pubmed PY - 2009/2/3/medline PY - 2008/11/8/entrez SP - 3266 EP - 76 JF - Brain : a journal of neurology JO - Brain VL - 131 IS - Pt 12 N2 - Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T(1)-weighted images were acquired from 19 Alzheimer's disease patients [age 76 +/- 6 years, three males, Mini-Mental State Examination 13 +/- 4] and 19 controls (age 74 +/- 5 years, 11 males, Mini-Mental State Examination 29 +/- 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P < 0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P < 0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/18988639/Mapping_local_hippocampal_changes_in_Alzheimer's_disease_and_normal_ageing_with_MRI_at_3_Tesla_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awn280 DB - PRIME DP - Unbound Medicine ER -