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Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial.
BJU Int. 2008 Nov; 102(9):1120-7.BI

Abstract

OBJECTIVES

To examine the effects of the antimuscarinic agent solifenacin on urinary urgency, using a range of novel and established outcome measures, as urgency is the principal symptom of the overactive bladder syndrome (OAB).

PATIENTS AND METHODS

The study (SUNRISE, solifenacin in the treatment of urgency symptoms of OAB in a rising dose, randomized, placebo-controlled, double-blind, efficacy trial) was a randomized, double-blind, 16-week, placebo-controlled, multicentre study of solifenacin 5/10 mg in 863 patients with symptoms of OAB for > or = 3 months. The primary efficacy variable was the change from baseline to endpoint in the number of episodes of severe urgency with or without urgency incontinence per 24 h, as measured using the Patient Perception of Intensity of Urgency Scale, grade 3 + 4. Secondary efficacy variables included patient-reported outcomes for bladder condition, urgency bother and treatment satisfaction. A 3-day voiding diary was used to record micturition frequency and episodes of urgency and incontinence. A 7-day diary was used to assess speed of onset of effect.

RESULTS

Solifenacin 5/10 mg was significantly more effective than placebo in reducing the mean number of episodes of severe urgency with or without incontinence per 24 h from baseline to endpoint (-2.6 vs -1.8, P < 0.001). There were also statistically significant differences in favour of solifenacin 5/10 mg over placebo for all secondary variables measured at endpoint, including patient-reported outcomes. There was a significant improvement in urgency as early as day 3 of treatment. Treatmente-mergent adverse events with solifenacin 5/10 mg were mainly mild or moderate in severity, and only led to discontinuation in 3.6% of patients.

CONCLUSION

Solifenacin significantly reduced the number of urgency episodes and the extent of urgency bother, and was well tolerated; it was effective as early as day 3 of treatment.

Authors+Show Affiliations

King's College Hospital, Department of Urogynaecology, London, UK. lcardozo@compuserve.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18990175

Citation

Cardozo, Linda, et al. "Solifenacin in the Treatment of Urgency and Other Symptoms of Overactive Bladder: Results From a Randomized, Double-blind, Placebo-controlled, Rising-dose Trial." BJU International, vol. 102, no. 9, 2008, pp. 1120-7.
Cardozo L, Hessdörfer E, Milani R, et al. Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial. BJU Int. 2008;102(9):1120-7.
Cardozo, L., Hessdörfer, E., Milani, R., Arañó, P., Dewilde, L., Slack, M., Drogendijk, T., Wright, M., & Bolodeoku, J. (2008). Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial. BJU International, 102(9), 1120-7. https://doi.org/10.1111/j.1464-410X.2008.07939.x
Cardozo L, et al. Solifenacin in the Treatment of Urgency and Other Symptoms of Overactive Bladder: Results From a Randomized, Double-blind, Placebo-controlled, Rising-dose Trial. BJU Int. 2008;102(9):1120-7. PubMed PMID: 18990175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial. AU - Cardozo,Linda, AU - Hessdörfer,Elke, AU - Milani,Rodolfo, AU - Arañó,Pedro, AU - Dewilde,Luc, AU - Slack,Mark, AU - Drogendijk,Ted, AU - Wright,Mark, AU - Bolodeoku,John, AU - ,, Y1 - 2008/10/06/ PY - 2008/11/8/pubmed PY - 2009/1/1/medline PY - 2008/11/8/entrez SP - 1120 EP - 7 JF - BJU international JO - BJU Int VL - 102 IS - 9 N2 - OBJECTIVES: To examine the effects of the antimuscarinic agent solifenacin on urinary urgency, using a range of novel and established outcome measures, as urgency is the principal symptom of the overactive bladder syndrome (OAB). PATIENTS AND METHODS: The study (SUNRISE, solifenacin in the treatment of urgency symptoms of OAB in a rising dose, randomized, placebo-controlled, double-blind, efficacy trial) was a randomized, double-blind, 16-week, placebo-controlled, multicentre study of solifenacin 5/10 mg in 863 patients with symptoms of OAB for > or = 3 months. The primary efficacy variable was the change from baseline to endpoint in the number of episodes of severe urgency with or without urgency incontinence per 24 h, as measured using the Patient Perception of Intensity of Urgency Scale, grade 3 + 4. Secondary efficacy variables included patient-reported outcomes for bladder condition, urgency bother and treatment satisfaction. A 3-day voiding diary was used to record micturition frequency and episodes of urgency and incontinence. A 7-day diary was used to assess speed of onset of effect. RESULTS: Solifenacin 5/10 mg was significantly more effective than placebo in reducing the mean number of episodes of severe urgency with or without incontinence per 24 h from baseline to endpoint (-2.6 vs -1.8, P < 0.001). There were also statistically significant differences in favour of solifenacin 5/10 mg over placebo for all secondary variables measured at endpoint, including patient-reported outcomes. There was a significant improvement in urgency as early as day 3 of treatment. Treatmente-mergent adverse events with solifenacin 5/10 mg were mainly mild or moderate in severity, and only led to discontinuation in 3.6% of patients. CONCLUSION: Solifenacin significantly reduced the number of urgency episodes and the extent of urgency bother, and was well tolerated; it was effective as early as day 3 of treatment. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/18990175/Solifenacin_in_the_treatment_of_urgency_and_other_symptoms_of_overactive_bladder:_results_from_a_randomized_double_blind_placebo_controlled_rising_dose_trial_ L2 - https://doi.org/10.1111/j.1464-410X.2008.07939.x DB - PRIME DP - Unbound Medicine ER -