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Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study.
Fertil Steril. 2009 Aug; 92(2):481-5.FS

Abstract

OBJECTIVE

To compare the efficacy of the microdose flare-up and multiple-dose antagonist protocols for poor-responder patients in intracytoplasmic sperm injection-ET cycles.

DESIGN

A randomized, prospective study.

SETTING

Center for assisted reproductive technology in Turkey.

PATIENT(S)

Ninety patients with poor ovarian response in a minimum of two previous IVF cycles.

INTERVENTION(S)

All women were prospectively randomized into two groups by computer-assisted randomization. The patients in group 1 were stimulated according to the microdose flare-up protocol (n = 45), while the patients in group 2 were stimulated according to antagonist multiple-dose protocol (n = 45).

MAIN OUTCOME MEASURE(S)

The mean number of mature oocytes retrieved was the primary outcome measure, and fertilization rate, implantation rate per embryo, and clinical pregnancy rates were secondary outcome measures.

RESULT(S)

The mean age of the women, the mean duration of infertility, basal FSH level, and the number of previous IVF cycles were similar in both groups. The total gonadotropin dose used was significantly higher in group 2, while the number of oocytes retrieved was significantly greater in group 1. Although the fertilization and clinical pregnancy rates were nonsignificantly higher in group 1 compared with group 2, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%).

CONCLUSION(S)

The microdose flare-up protocol seems to have a better outcome in poor-responder patients, with a significantly higher mean number of mature oocytes retrieved and higher implantation rate.

Authors+Show Affiliations

Clinic Women Health, Infertility and IVF Center, Hacettepe University Faculty of Medicine, Ankara, Turkey. ademirol@gmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18990368

Citation

Demirol, Aygul, and Timur Gurgan. "Comparison of Microdose Flare-up and Antagonist Multiple-dose Protocols for Poor-responder Patients: a Randomized Study." Fertility and Sterility, vol. 92, no. 2, 2009, pp. 481-5.
Demirol A, Gurgan T. Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study. Fertil Steril. 2009;92(2):481-5.
Demirol, A., & Gurgan, T. (2009). Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study. Fertility and Sterility, 92(2), 481-5. https://doi.org/10.1016/j.fertnstert.2008.07.006
Demirol A, Gurgan T. Comparison of Microdose Flare-up and Antagonist Multiple-dose Protocols for Poor-responder Patients: a Randomized Study. Fertil Steril. 2009;92(2):481-5. PubMed PMID: 18990368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study. AU - Demirol,Aygul, AU - Gurgan,Timur, Y1 - 2008/11/05/ PY - 2006/11/05/received PY - 2008/06/21/revised PY - 2008/07/09/accepted PY - 2008/11/8/pubmed PY - 2009/8/28/medline PY - 2008/11/8/entrez SP - 481 EP - 5 JF - Fertility and sterility JO - Fertil Steril VL - 92 IS - 2 N2 - OBJECTIVE: To compare the efficacy of the microdose flare-up and multiple-dose antagonist protocols for poor-responder patients in intracytoplasmic sperm injection-ET cycles. DESIGN: A randomized, prospective study. SETTING: Center for assisted reproductive technology in Turkey. PATIENT(S): Ninety patients with poor ovarian response in a minimum of two previous IVF cycles. INTERVENTION(S): All women were prospectively randomized into two groups by computer-assisted randomization. The patients in group 1 were stimulated according to the microdose flare-up protocol (n = 45), while the patients in group 2 were stimulated according to antagonist multiple-dose protocol (n = 45). MAIN OUTCOME MEASURE(S): The mean number of mature oocytes retrieved was the primary outcome measure, and fertilization rate, implantation rate per embryo, and clinical pregnancy rates were secondary outcome measures. RESULT(S): The mean age of the women, the mean duration of infertility, basal FSH level, and the number of previous IVF cycles were similar in both groups. The total gonadotropin dose used was significantly higher in group 2, while the number of oocytes retrieved was significantly greater in group 1. Although the fertilization and clinical pregnancy rates were nonsignificantly higher in group 1 compared with group 2, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). CONCLUSION(S): The microdose flare-up protocol seems to have a better outcome in poor-responder patients, with a significantly higher mean number of mature oocytes retrieved and higher implantation rate. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18990368/Comparison_of_microdose_flare_up_and_antagonist_multiple_dose_protocols_for_poor_responder_patients:_a_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)01457-X DB - PRIME DP - Unbound Medicine ER -