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Oxygen uptake of the human fetus at term.

Abstract

OBJECTIVE

To measure oxygen uptake of term human fetuses and compare the values between those delivered vaginally following normal labor and those delivered by cesarean section before the onset of labor.

DESIGN

This was a prospective cross-sectional study.

SETTING

University teaching hospital.

SAMPLE

Twenty healthy pregnant women at term (38-42 weeks) were included in this study. Among them, 10 were delivered by elective cesarean section and 10 had normal vaginal delivery.

METHODS

Umbilical vein volume blood flow was measured <24 hours before delivery. Immediately after delivery, the fetal weight was determined, and the umbilical venous and arterial blood samples were obtained. Blood gas analysis was performed and hemoglobin content was measured. Fetal oxygen uptake was calculated as a product of umbilical venous blood flow and the difference in the umbilical arterial and venous oxygen content.

RESULTS

We found that the mean oxygen uptake in human fetuses at term (median gestational age 39 weeks) to be 6.58 ml/min/kg (i.e. 0.29 mmol/min/kg). There was no significant difference in oxygen uptake between fetuses delivered following uncomplicated normal labor and those delivered by elective cesarean section before the onset of labor.

CONCLUSION

Oxygen uptake of the appropriately grown normal human fetus at term is approximately 6.6 ml/kg/min and is not significantly affected by normal labor and delivery. Human fetuses tolerate intermittent reductions in uterine blood flow and oxygen supply associated with myometrial contractions during normal labor quite well.

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  • Authors+Show Affiliations

    ,

    Faculty of Medicine, Institute of Clinical Medicine, University of Tromsø and University Hospital of Northern Norway, Tromsø, Norway. ganesh.acharya@fagmed.uit.no

    Source

    MeSH

    Acid-Base Equilibrium
    Adult
    Blood Flow Velocity
    Blood Gas Analysis
    Cesarean Section
    Cross-Sectional Studies
    Delivery, Obstetric
    Female
    Fetal Development
    Fetal Monitoring
    Fetal Weight
    Follow-Up Studies
    Humans
    Infant, Newborn
    Oxygen Consumption
    Placental Circulation
    Pregnancy
    Pregnancy Outcome
    Pregnancy Trimester, Third
    Probability
    Prospective Studies
    Statistics, Nonparametric
    Term Birth
    Umbilical Veins
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18991146

    Citation

    Acharya, Ganesh, and Vasilis Sitras. "Oxygen Uptake of the Human Fetus at Term." Acta Obstetricia Et Gynecologica Scandinavica, vol. 88, no. 1, 2009, pp. 104-9.
    Acharya G, Sitras V. Oxygen uptake of the human fetus at term. Acta Obstet Gynecol Scand. 2009;88(1):104-9.
    Acharya, G., & Sitras, V. (2009). Oxygen uptake of the human fetus at term. Acta Obstetricia Et Gynecologica Scandinavica, 88(1), pp. 104-9. doi:10.1080/00016340802460339.
    Acharya G, Sitras V. Oxygen Uptake of the Human Fetus at Term. Acta Obstet Gynecol Scand. 2009;88(1):104-9. PubMed PMID: 18991146.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxygen uptake of the human fetus at term. AU - Acharya,Ganesh, AU - Sitras,Vasilis, PY - 2008/11/11/pubmed PY - 2009/2/5/medline PY - 2008/11/11/entrez SP - 104 EP - 9 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 88 IS - 1 N2 - OBJECTIVE: To measure oxygen uptake of term human fetuses and compare the values between those delivered vaginally following normal labor and those delivered by cesarean section before the onset of labor. DESIGN: This was a prospective cross-sectional study. SETTING: University teaching hospital. SAMPLE: Twenty healthy pregnant women at term (38-42 weeks) were included in this study. Among them, 10 were delivered by elective cesarean section and 10 had normal vaginal delivery. METHODS: Umbilical vein volume blood flow was measured <24 hours before delivery. Immediately after delivery, the fetal weight was determined, and the umbilical venous and arterial blood samples were obtained. Blood gas analysis was performed and hemoglobin content was measured. Fetal oxygen uptake was calculated as a product of umbilical venous blood flow and the difference in the umbilical arterial and venous oxygen content. RESULTS: We found that the mean oxygen uptake in human fetuses at term (median gestational age 39 weeks) to be 6.58 ml/min/kg (i.e. 0.29 mmol/min/kg). There was no significant difference in oxygen uptake between fetuses delivered following uncomplicated normal labor and those delivered by elective cesarean section before the onset of labor. CONCLUSION: Oxygen uptake of the appropriately grown normal human fetus at term is approximately 6.6 ml/kg/min and is not significantly affected by normal labor and delivery. Human fetuses tolerate intermittent reductions in uterine blood flow and oxygen supply associated with myometrial contractions during normal labor quite well. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/18991146/Oxygen_uptake_of_the_human_fetus_at_term_ L2 - https://doi.org/10.1080/00016340802460339 DB - PRIME DP - Unbound Medicine ER -