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Oxygen uptake of the human fetus at term.
Acta Obstet Gynecol Scand 2009; 88(1):104-9AO

Abstract

OBJECTIVE

To measure oxygen uptake of term human fetuses and compare the values between those delivered vaginally following normal labor and those delivered by cesarean section before the onset of labor.

DESIGN

This was a prospective cross-sectional study.

SETTING

University teaching hospital.

SAMPLE

Twenty healthy pregnant women at term (38-42 weeks) were included in this study. Among them, 10 were delivered by elective cesarean section and 10 had normal vaginal delivery.

METHODS

Umbilical vein volume blood flow was measured <24 hours before delivery. Immediately after delivery, the fetal weight was determined, and the umbilical venous and arterial blood samples were obtained. Blood gas analysis was performed and hemoglobin content was measured. Fetal oxygen uptake was calculated as a product of umbilical venous blood flow and the difference in the umbilical arterial and venous oxygen content.

RESULTS

We found that the mean oxygen uptake in human fetuses at term (median gestational age 39 weeks) to be 6.58 ml/min/kg (i.e. 0.29 mmol/min/kg). There was no significant difference in oxygen uptake between fetuses delivered following uncomplicated normal labor and those delivered by elective cesarean section before the onset of labor.

CONCLUSION

Oxygen uptake of the appropriately grown normal human fetus at term is approximately 6.6 ml/kg/min and is not significantly affected by normal labor and delivery. Human fetuses tolerate intermittent reductions in uterine blood flow and oxygen supply associated with myometrial contractions during normal labor quite well.

Authors+Show Affiliations

Faculty of Medicine, Institute of Clinical Medicine, University of Tromsø and University Hospital of Northern Norway, Tromsø, Norway. ganesh.acharya@fagmed.uit.noNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18991146

Citation

Acharya, Ganesh, and Vasilis Sitras. "Oxygen Uptake of the Human Fetus at Term." Acta Obstetricia Et Gynecologica Scandinavica, vol. 88, no. 1, 2009, pp. 104-9.
Acharya G, Sitras V. Oxygen uptake of the human fetus at term. Acta Obstet Gynecol Scand. 2009;88(1):104-9.
Acharya, G., & Sitras, V. (2009). Oxygen uptake of the human fetus at term. Acta Obstetricia Et Gynecologica Scandinavica, 88(1), pp. 104-9. doi:10.1080/00016340802460339.
Acharya G, Sitras V. Oxygen Uptake of the Human Fetus at Term. Acta Obstet Gynecol Scand. 2009;88(1):104-9. PubMed PMID: 18991146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen uptake of the human fetus at term. AU - Acharya,Ganesh, AU - Sitras,Vasilis, PY - 2008/11/11/pubmed PY - 2009/2/5/medline PY - 2008/11/11/entrez SP - 104 EP - 9 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 88 IS - 1 N2 - OBJECTIVE: To measure oxygen uptake of term human fetuses and compare the values between those delivered vaginally following normal labor and those delivered by cesarean section before the onset of labor. DESIGN: This was a prospective cross-sectional study. SETTING: University teaching hospital. SAMPLE: Twenty healthy pregnant women at term (38-42 weeks) were included in this study. Among them, 10 were delivered by elective cesarean section and 10 had normal vaginal delivery. METHODS: Umbilical vein volume blood flow was measured <24 hours before delivery. Immediately after delivery, the fetal weight was determined, and the umbilical venous and arterial blood samples were obtained. Blood gas analysis was performed and hemoglobin content was measured. Fetal oxygen uptake was calculated as a product of umbilical venous blood flow and the difference in the umbilical arterial and venous oxygen content. RESULTS: We found that the mean oxygen uptake in human fetuses at term (median gestational age 39 weeks) to be 6.58 ml/min/kg (i.e. 0.29 mmol/min/kg). There was no significant difference in oxygen uptake between fetuses delivered following uncomplicated normal labor and those delivered by elective cesarean section before the onset of labor. CONCLUSION: Oxygen uptake of the appropriately grown normal human fetus at term is approximately 6.6 ml/kg/min and is not significantly affected by normal labor and delivery. Human fetuses tolerate intermittent reductions in uterine blood flow and oxygen supply associated with myometrial contractions during normal labor quite well. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/18991146/Oxygen_uptake_of_the_human_fetus_at_term_ L2 - https://doi.org/10.1080/00016340802460339 DB - PRIME DP - Unbound Medicine ER -