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Antimicrobially active isoquinoline alkaloids from Litsea cubeba.
Planta Med. 2009 Jan; 75(1):76-9.PM

Abstract

Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)- N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were established by extensive spectroscopic techniques and by comparing spectroscopic data with those in the literature. Compounds 1 and 4 showed antimicrobial activities. This is the first report on the presence of compounds 1, 2, 6, 8, 9, 11, and 12 in this plant and on the antimicrobial activities of 1 and 4. The bioactivities of isoquinoline alkaloids are also at least partly responsible for the pharmacological function of the folk medicinal plant Litsea cubeba.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Feng T
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Xu Y
No affiliation info available
Cai XH
No affiliation info available
Du ZZ
No affiliation info available
Luo XD
No affiliation info available

MeSH

AlkaloidsAnti-Infective AgentsChemical FractionationFungiIsoquinolinesLitseaMicrobial Sensitivity TestsMycobacterium tuberculosisPlant Components, AerialPlant ExtractsStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18991207

Citation

Feng, Tao, et al. "Antimicrobially Active Isoquinoline Alkaloids From Litsea Cubeba." Planta Medica, vol. 75, no. 1, 2009, pp. 76-9.
Feng T, Xu Y, Cai XH, et al. Antimicrobially active isoquinoline alkaloids from Litsea cubeba. Planta Med. 2009;75(1):76-9.
Feng, T., Xu, Y., Cai, X. H., Du, Z. Z., & Luo, X. D. (2009). Antimicrobially active isoquinoline alkaloids from Litsea cubeba. Planta Medica, 75(1), 76-9. https://doi.org/10.1055/s-0028-1088344
Feng T, et al. Antimicrobially Active Isoquinoline Alkaloids From Litsea Cubeba. Planta Med. 2009;75(1):76-9. PubMed PMID: 18991207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobially active isoquinoline alkaloids from Litsea cubeba. AU - Feng,Tao, AU - Xu,Yan, AU - Cai,Xiang-Hai, AU - Du,Zhi-Zhi, AU - Luo,Xiao-Dong, Y1 - 2008/11/07/ PY - 2008/11/11/pubmed PY - 2009/4/21/medline PY - 2008/11/11/entrez SP - 76 EP - 9 JF - Planta medica JO - Planta Med VL - 75 IS - 1 N2 - Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)- N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were established by extensive spectroscopic techniques and by comparing spectroscopic data with those in the literature. Compounds 1 and 4 showed antimicrobial activities. This is the first report on the presence of compounds 1, 2, 6, 8, 9, 11, and 12 in this plant and on the antimicrobial activities of 1 and 4. The bioactivities of isoquinoline alkaloids are also at least partly responsible for the pharmacological function of the folk medicinal plant Litsea cubeba. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/18991207/Antimicrobially_active_isoquinoline_alkaloids_from_Litsea_cubeba_ DB - PRIME DP - Unbound Medicine ER -