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Hepatitis E: an emerging infection in developed countries.
Lancet Infect Dis. 2008 Nov; 8(11):698-709.LI

Abstract

Hepatitis E is endemic in many developing countries where it causes substantial morbidity. In industrialised countries, it is considered rare, and largely confined to travellers returning from endemic areas. However, there is now a growing body of evidence that challenges this notion. Autochthonous hepatitis E in developed countries is far more common than previously recognised, and might be more common than hepatitis A. Hepatitis E has a predilection for older men in whom it causes substantial morbidity and mortality. The disease has a poor prognosis in the context of pre-existing chronic liver disease, and is frequently misdiagnosed as drug-induced liver injury. The source and route of infection remain uncertain, but it might be a porcine zoonosis. Patients with unexplained hepatitis should be tested for hepatitis E, whatever their age or travel history.

Authors+Show Affiliations

Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, UK. harry.dalton@rcht.cornwall.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18992406

Citation

Dalton, Harry R., et al. "Hepatitis E: an Emerging Infection in Developed Countries." The Lancet. Infectious Diseases, vol. 8, no. 11, 2008, pp. 698-709.
Dalton HR, Bendall R, Ijaz S, et al. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis. 2008;8(11):698-709.
Dalton, H. R., Bendall, R., Ijaz, S., & Banks, M. (2008). Hepatitis E: an emerging infection in developed countries. The Lancet. Infectious Diseases, 8(11), 698-709. https://doi.org/10.1016/S1473-3099(08)70255-X
Dalton HR, et al. Hepatitis E: an Emerging Infection in Developed Countries. Lancet Infect Dis. 2008;8(11):698-709. PubMed PMID: 18992406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E: an emerging infection in developed countries. AU - Dalton,Harry R, AU - Bendall,Richard, AU - Ijaz,Samreen, AU - Banks,Malcolm, PY - 2008/11/11/pubmed PY - 2008/12/24/medline PY - 2008/11/11/entrez SP - 698 EP - 709 JF - The Lancet. Infectious diseases JO - Lancet Infect Dis VL - 8 IS - 11 N2 - Hepatitis E is endemic in many developing countries where it causes substantial morbidity. In industrialised countries, it is considered rare, and largely confined to travellers returning from endemic areas. However, there is now a growing body of evidence that challenges this notion. Autochthonous hepatitis E in developed countries is far more common than previously recognised, and might be more common than hepatitis A. Hepatitis E has a predilection for older men in whom it causes substantial morbidity and mortality. The disease has a poor prognosis in the context of pre-existing chronic liver disease, and is frequently misdiagnosed as drug-induced liver injury. The source and route of infection remain uncertain, but it might be a porcine zoonosis. Patients with unexplained hepatitis should be tested for hepatitis E, whatever their age or travel history. SN - 1473-3099 UR - https://www.unboundmedicine.com/medline/citation/18992406/Hepatitis_E:_an_emerging_infection_in_developed_countries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-3099(08)70255-X DB - PRIME DP - Unbound Medicine ER -