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Parasitic brain infection, endocannabinoids, and schizophrenia.

Abstract

Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocannabinoid system have been considered as possible causes of various forms of mental illness and abnormal behavior. In this paper, a novel hypothesis is presented that suggests that an as yet undefined subset of schizophrenia is caused by an excess of endocannabinoids that are produced to protect the brain in response to infections by agents such as Toxoplasma gondii.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Biology Department, University of Colorado at Colorado, Springs, Colorado Springs, CO 80918, USA. rmelamed@uccs.edu

    Source

    Medical hypotheses 72:2 2009 Feb pg 220-2

    MeSH

    Cannabinoid Receptor Modulators
    Central Nervous System Parasitic Infections
    Endocannabinoids
    Humans
    Schizophrenia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18995970

    Citation

    TY - JOUR T1 - Parasitic brain infection, endocannabinoids, and schizophrenia. A1 - Melamede,Robert, Y1 - 2008/11/07/ PY - 2008/08/04/received PY - 2008/08/04/revised PY - 2008/08/15/accepted PY - 2008/11/11/pubmed PY - 2009/4/1/medline PY - 2008/11/11/entrez SP - 220 EP - 2 JF - Medical hypotheses JO - Med. Hypotheses VL - 72 IS - 2 N2 - Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocannabinoid system have been considered as possible causes of various forms of mental illness and abnormal behavior. In this paper, a novel hypothesis is presented that suggests that an as yet undefined subset of schizophrenia is caused by an excess of endocannabinoids that are produced to protect the brain in response to infections by agents such as Toxoplasma gondii. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/18995970/abstract/Parasitic_brain_infection_endocannabinoids_and_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(08)00491-X ER -