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Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).
Bioorg Med Chem. 2008 Dec 01; 16(23):9984-90.BM

Abstract

Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC(50) value 15.5+/-1.2microM.

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Authors+Show Affiliations

Shang L
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, PR China.
Wang Q
No affiliation info available
Fang H
No affiliation info available
Mu J
No affiliation info available
Wang X
No affiliation info available
Yuan Y
No affiliation info available
Wang B
No affiliation info available
Xu W
No affiliation info available

MeSH

CD13 AntigensCells, CulturedDiaminesHL-60 CellsHumansInhibitory Concentration 50Matrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMicrosomesProtease InhibitorsStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18996018

Citation

Shang, Luqing, et al. "Novel 3-phenylpropane-1,2-diamine Derivates as Inhibitors of Aminopeptidase N (APN)." Bioorganic & Medicinal Chemistry, vol. 16, no. 23, 2008, pp. 9984-90.
Shang L, Wang Q, Fang H, et al. Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN). Bioorg Med Chem. 2008;16(23):9984-90.
Shang, L., Wang, Q., Fang, H., Mu, J., Wang, X., Yuan, Y., Wang, B., & Xu, W. (2008). Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry, 16(23), 9984-90. https://doi.org/10.1016/j.bmc.2008.10.025
Shang L, et al. Novel 3-phenylpropane-1,2-diamine Derivates as Inhibitors of Aminopeptidase N (APN). Bioorg Med Chem. 2008 Dec 1;16(23):9984-90. PubMed PMID: 18996018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN). AU - Shang,Luqing, AU - Wang,Qiang, AU - Fang,Hao, AU - Mu,Jiajia, AU - Wang,Xuejian, AU - Yuan,Yumei, AU - Wang,Binghe, AU - Xu,Wenfang, Y1 - 2008/10/14/ PY - 2008/08/26/received PY - 2008/10/09/revised PY - 2008/10/10/accepted PY - 2008/11/11/pubmed PY - 2009/1/10/medline PY - 2008/11/11/entrez SP - 9984 EP - 90 JF - Bioorganic & medicinal chemistry JO - Bioorg Med Chem VL - 16 IS - 23 N2 - Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC(50) value 15.5+/-1.2microM. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/18996018/Novel_3_phenylpropane_12_diamine_derivates_as_inhibitors_of_aminopeptidase_N__APN__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(08)00975-9 DB - PRIME DP - Unbound Medicine ER -