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Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen.

Abstract

In this study, 42 female Wistar albino rats, weighing between 200 and 250 g, were used and they were divided into six equal groups. Group 1 was allocated as the control group. Rats included in groups 2 and 3 were administered a water-solubilized extract of bee pollen at a dose of 50 mg/kg bw/day and 100 mg/kg bw/day, respectively. Group 4 received 225 mg/kg bw/day carbaryl. Groups 5 and 6 were given a water-solubilized extract of bee pollen at a dose of 50 mg/kg bw/day and 100mg/kg bw/day, respectively, plus 225 mg/kg bw/day carbaryl. The indicated administrations were continued for 21 days for groups 1-6 by gavage. MDA levels and the activities of CAT, SOD and GSH-Px were analysed in blood and tissues (liver, kidney, brain and heart). At the same time, levels/activities of total protein, albumin, glucose, triglyceride, T-cholesterol, T-bilirubin, BUN, creatinine, uric acid, GGT, LDH, AST, ALT and ALP, magnesium, sodium, potassium and chloride were evaluated in serum samples. In conclusion, carbaryl was determined to cause negative changes in most of the oxidative stress markers and serum biochemical parameters investigated. These effects were observed to alleviate with the administration of bee pollen.

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  • Authors+Show Affiliations

    ,

    University of Erciyes, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 38090, Kocasinan, Kayseri, Turkey. geraslan38@hotmail.com

    ,

    Source

    MeSH

    Animals
    Bees
    Biomarkers
    Brain
    Carbaryl
    Erythrocytes
    Female
    Heart
    Kidney
    Liver
    Myocardium
    Oxidative Stress
    Pollen
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18996165

    Citation

    Eraslan, Gökhan, et al. "Effect of Carbaryl On some Biochemical Changes in Rats: the Ameliorative Effect of Bee Pollen." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 1, 2009, pp. 86-91.
    Eraslan G, Kanbur M, Silici S. Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem Toxicol. 2009;47(1):86-91.
    Eraslan, G., Kanbur, M., & Silici, S. (2009). Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(1), pp. 86-91. doi:10.1016/j.fct.2008.10.013.
    Eraslan G, Kanbur M, Silici S. Effect of Carbaryl On some Biochemical Changes in Rats: the Ameliorative Effect of Bee Pollen. Food Chem Toxicol. 2009;47(1):86-91. PubMed PMID: 18996165.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. AU - Eraslan,Gökhan, AU - Kanbur,Murat, AU - Silici,Sibel, Y1 - 2008/10/21/ PY - 2008/01/18/received PY - 2008/10/04/revised PY - 2008/10/13/accepted PY - 2008/11/11/pubmed PY - 2009/3/17/medline PY - 2008/11/11/entrez SP - 86 EP - 91 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 47 IS - 1 N2 - In this study, 42 female Wistar albino rats, weighing between 200 and 250 g, were used and they were divided into six equal groups. Group 1 was allocated as the control group. Rats included in groups 2 and 3 were administered a water-solubilized extract of bee pollen at a dose of 50 mg/kg bw/day and 100 mg/kg bw/day, respectively. Group 4 received 225 mg/kg bw/day carbaryl. Groups 5 and 6 were given a water-solubilized extract of bee pollen at a dose of 50 mg/kg bw/day and 100mg/kg bw/day, respectively, plus 225 mg/kg bw/day carbaryl. The indicated administrations were continued for 21 days for groups 1-6 by gavage. MDA levels and the activities of CAT, SOD and GSH-Px were analysed in blood and tissues (liver, kidney, brain and heart). At the same time, levels/activities of total protein, albumin, glucose, triglyceride, T-cholesterol, T-bilirubin, BUN, creatinine, uric acid, GGT, LDH, AST, ALT and ALP, magnesium, sodium, potassium and chloride were evaluated in serum samples. In conclusion, carbaryl was determined to cause negative changes in most of the oxidative stress markers and serum biochemical parameters investigated. These effects were observed to alleviate with the administration of bee pollen. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/18996165/Effect_of_carbaryl_on_some_biochemical_changes_in_rats:_the_ameliorative_effect_of_bee_pollen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00595-4 DB - PRIME DP - Unbound Medicine ER -