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Theory of mind deficit in bipolar disorder: is it related to a previous history of psychotic symptoms?
Psychiatry Res. 2008 Dec 15; 161(3):309-17.PR

Abstract

It has been hypothesized that a Theory of Mind (ToM) deficit could be a vulnerability marker for psychosis. Recent studies, however, have shown ToM deficits in affective relapses of bipolar disorder as well as in the euthymic phase. This study analyzes the relationship between ToM and a previous history of psychotic symptoms in bipolar disorder. ToM, sustained attention and executive functions were analyzed in 75 bipolar euthymic patients with three or more previous relapses (42 of them had a history of psychotic symptoms and 33 did not) and 48 healthy subjects. ToM was assessed with the Advanced Test by Happé. ToM performance was similar in bipolar patients with or without a history of psychotic symptoms, and in both cases it was significantly reduced as compared with the healthy control group. Similarly, both bipolar groups showed impaired sustained attention and executive functions. This general cognitive deficit partially explains the differences obtained in ToM. The ToM instrument used shows low sensitivity for assessing ToM in bipolar patients and it could partially reflect general cognitive functioning rather than a specific deficit in psychosis. ToM deficit is not a trait marker for psychosis, given that it is present in bipolar disorder regardless of a previous history of psychotic symptoms.

Authors+Show Affiliations

Psychiatry Department, Principe de Asturias University Hospital, University of Alcalá, Madrid, Spain. guillermo.lahera@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18996602

Citation

Lahera, Guillermo, et al. "Theory of Mind Deficit in Bipolar Disorder: Is It Related to a Previous History of Psychotic Symptoms?" Psychiatry Research, vol. 161, no. 3, 2008, pp. 309-17.
Lahera G, Montes JM, Benito A, et al. Theory of mind deficit in bipolar disorder: is it related to a previous history of psychotic symptoms? Psychiatry Res. 2008;161(3):309-17.
Lahera, G., Montes, J. M., Benito, A., Valdivia, M., Medina, E., Mirapeix, I., & Sáiz-Ruiz, J. (2008). Theory of mind deficit in bipolar disorder: is it related to a previous history of psychotic symptoms? Psychiatry Research, 161(3), 309-17. https://doi.org/10.1016/j.psychres.2007.08.009
Lahera G, et al. Theory of Mind Deficit in Bipolar Disorder: Is It Related to a Previous History of Psychotic Symptoms. Psychiatry Res. 2008 Dec 15;161(3):309-17. PubMed PMID: 18996602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Theory of mind deficit in bipolar disorder: is it related to a previous history of psychotic symptoms? AU - Lahera,Guillermo, AU - Montes,José Manuel, AU - Benito,Adolfo, AU - Valdivia,María, AU - Medina,Elena, AU - Mirapeix,Isabel, AU - Sáiz-Ruiz,Jerónimo, Y1 - 2008/11/08/ PY - 2007/04/02/received PY - 2007/07/17/revised PY - 2007/08/11/accepted PY - 2008/11/11/pubmed PY - 2009/2/5/medline PY - 2008/11/11/entrez SP - 309 EP - 17 JF - Psychiatry research JO - Psychiatry Res VL - 161 IS - 3 N2 - It has been hypothesized that a Theory of Mind (ToM) deficit could be a vulnerability marker for psychosis. Recent studies, however, have shown ToM deficits in affective relapses of bipolar disorder as well as in the euthymic phase. This study analyzes the relationship between ToM and a previous history of psychotic symptoms in bipolar disorder. ToM, sustained attention and executive functions were analyzed in 75 bipolar euthymic patients with three or more previous relapses (42 of them had a history of psychotic symptoms and 33 did not) and 48 healthy subjects. ToM was assessed with the Advanced Test by Happé. ToM performance was similar in bipolar patients with or without a history of psychotic symptoms, and in both cases it was significantly reduced as compared with the healthy control group. Similarly, both bipolar groups showed impaired sustained attention and executive functions. This general cognitive deficit partially explains the differences obtained in ToM. The ToM instrument used shows low sensitivity for assessing ToM in bipolar patients and it could partially reflect general cognitive functioning rather than a specific deficit in psychosis. ToM deficit is not a trait marker for psychosis, given that it is present in bipolar disorder regardless of a previous history of psychotic symptoms. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/18996602/Theory_of_mind_deficit_in_bipolar_disorder:_is_it_related_to_a_previous_history_of_psychotic_symptoms L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(07)00293-4 DB - PRIME DP - Unbound Medicine ER -