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Contribution of vascular pathology to the clinical expression of dementia.
Neurobiol Aging. 2010 Oct; 31(10):1710-20.NA

Abstract

Vascular lesions in the brain are common with advancing age; however, the independent and cumulative contributions of postmortem vascular lesions to antemortem cognitive status are not well established. We examined association of six vascular lesions (large infarcts, lacunar infarcts, leukoencephalopathy, microinfarcts, cribriform changes, and cerebral amyloid angiopathy) with antemortem diagnoses of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in 190 older adults from an autopsy series. We also developed a summary score based on three macroscopic vascular lesions: large infarcts (0, 1, and >or=2), lacunar infarcts (0, 1, and >or=2), and leukoencephalopathy (none, mild, and moderate-to-severe). Sixty-eight percent of cases had vascular lesions. Only leukoencephalopathy was associated with dementia (odds ratio (OR) 3.5, 95% CI 1.0-12.4), and only large infarcts were associated with VaD (OR 4.3, 95% CI 1.2-15.4). The vascular score was associated with dementia (OR 1.6, 95% CI 1.2-2.3), AD (OR 1.5, 95% CI 1.0-2.1) and VaD (OR 2.0, 95% CI 1.4-3.0). Leukoencephalopathy, large infarcts, and higher vascular burden is associated with the clinical expression of dementia and subtypes.

Authors+Show Affiliations

Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18996621

Citation

Strozyk, Dorothea, et al. "Contribution of Vascular Pathology to the Clinical Expression of Dementia." Neurobiology of Aging, vol. 31, no. 10, 2010, pp. 1710-20.
Strozyk D, Dickson DW, Lipton RB, et al. Contribution of vascular pathology to the clinical expression of dementia. Neurobiol Aging. 2010;31(10):1710-20.
Strozyk, D., Dickson, D. W., Lipton, R. B., Katz, M., Derby, C. A., Lee, S., Wang, C., & Verghese, J. (2010). Contribution of vascular pathology to the clinical expression of dementia. Neurobiology of Aging, 31(10), 1710-20. https://doi.org/10.1016/j.neurobiolaging.2008.09.011
Strozyk D, et al. Contribution of Vascular Pathology to the Clinical Expression of Dementia. Neurobiol Aging. 2010;31(10):1710-20. PubMed PMID: 18996621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of vascular pathology to the clinical expression of dementia. AU - Strozyk,Dorothea, AU - Dickson,Dennis W, AU - Lipton,Richard B, AU - Katz,Mindy, AU - Derby,Carol A, AU - Lee,Sunhee, AU - Wang,Cuiling, AU - Verghese,Joe, Y1 - 2008/11/08/ PY - 2008/07/24/received PY - 2008/09/15/revised PY - 2008/09/18/accepted PY - 2008/11/11/pubmed PY - 2010/12/25/medline PY - 2008/11/11/entrez SP - 1710 EP - 20 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 31 IS - 10 N2 - Vascular lesions in the brain are common with advancing age; however, the independent and cumulative contributions of postmortem vascular lesions to antemortem cognitive status are not well established. We examined association of six vascular lesions (large infarcts, lacunar infarcts, leukoencephalopathy, microinfarcts, cribriform changes, and cerebral amyloid angiopathy) with antemortem diagnoses of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in 190 older adults from an autopsy series. We also developed a summary score based on three macroscopic vascular lesions: large infarcts (0, 1, and >or=2), lacunar infarcts (0, 1, and >or=2), and leukoencephalopathy (none, mild, and moderate-to-severe). Sixty-eight percent of cases had vascular lesions. Only leukoencephalopathy was associated with dementia (odds ratio (OR) 3.5, 95% CI 1.0-12.4), and only large infarcts were associated with VaD (OR 4.3, 95% CI 1.2-15.4). The vascular score was associated with dementia (OR 1.6, 95% CI 1.2-2.3), AD (OR 1.5, 95% CI 1.0-2.1) and VaD (OR 2.0, 95% CI 1.4-3.0). Leukoencephalopathy, large infarcts, and higher vascular burden is associated with the clinical expression of dementia and subtypes. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/18996621/Contribution_of_vascular_pathology_to_the_clinical_expression_of_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(08)00336-9 DB - PRIME DP - Unbound Medicine ER -