Tags

Type your tag names separated by a space and hit enter

Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Am J Clin Nutr 2008; 88(5):1304-12AJ

Abstract

BACKGROUND

Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer.

OBJECTIVE

We aimed to investigate the association between fat consumption and breast cancer.

DESIGN

We prospectively investigated fat consumption in a large (n = 319,826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer.

RESULTS

An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable].

CONCLUSIONS

Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy.

Authors+Show Affiliations

Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18996867

Citation

Sieri, Sabina, et al. "Dietary Fat and Breast Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition." The American Journal of Clinical Nutrition, vol. 88, no. 5, 2008, pp. 1304-12.
Sieri S, Krogh V, Ferrari P, et al. Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2008;88(5):1304-12.
Sieri, S., Krogh, V., Ferrari, P., Berrino, F., Pala, V., Thiébaut, A. C., ... Riboli, E. (2008). Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. The American Journal of Clinical Nutrition, 88(5), pp. 1304-12.
Sieri S, et al. Dietary Fat and Breast Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition. Am J Clin Nutr. 2008;88(5):1304-12. PubMed PMID: 18996867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. AU - Sieri,Sabina, AU - Krogh,Vittorio, AU - Ferrari,Pietro, AU - Berrino,Franco, AU - Pala,Valeria, AU - Thiébaut,Anne C M, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Overvad,Kim, AU - Jakobsen,Marianne Uhre, AU - Clavel-Chapelon,Francoise, AU - Chajes,Veronique, AU - Boutron-Ruault,Marie-Christine, AU - Kaaks,Rudolf, AU - Linseisen,Jakob, AU - Boeing,Heiner, AU - Nöthlings,Ute, AU - Trichopoulou,Antonia, AU - Naska,Androniki, AU - Lagiou,Pagona, AU - Panico,Salvatore, AU - Palli,Domenico, AU - Vineis,Paolo, AU - Tumino,Rosario, AU - Lund,Eiliv, AU - Kumle,Merethe, AU - Skeie,Guri, AU - González,Carlos A, AU - Ardanaz,Eva, AU - Amiano,Pilar, AU - Tormo,María José, AU - Martínez-García,Carmen, AU - Quirós,Jose R, AU - Berglund,Göran, AU - Gullberg,Bo, AU - Hallmans,Göran, AU - Lenner,Per, AU - Bueno-de-Mesquita,H Bas, AU - van Duijnhoven,Fränzel J B, AU - Peeters,Petra H M, AU - van Gils,Carla H, AU - Key,Timothy J, AU - Crowe,Francesca L, AU - Bingham,Sheila, AU - Khaw,Kay Tee, AU - Rinaldi,Sabina, AU - Slimani,Nadia, AU - Jenab,Mazda, AU - Norat,Teresa, AU - Riboli,Elio, PY - 2008/11/11/pubmed PY - 2008/12/17/medline PY - 2008/11/11/entrez SP - 1304 EP - 12 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 88 IS - 5 N2 - BACKGROUND: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. OBJECTIVE: We aimed to investigate the association between fat consumption and breast cancer. DESIGN: We prospectively investigated fat consumption in a large (n = 319,826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. RESULTS: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. CONCLUSIONS: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18996867/Dietary_fat_and_breast_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26090 DB - PRIME DP - Unbound Medicine ER -