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Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome.
Ann Nutr Metab. 2008; 53(2):137-42.AN

Abstract

Plasma citrulline is known to be a marker of absorptive enterocyte mass in humans. We evaluated whether citrulline and other blood amino acids are indicators of residual small intestinal length and therefore potential predictors of dependence on parenteral nutrition in the long term. We studied 25 patients with short bowel syndrome (SBS) after at least 18 months since last digestive circuit modification; 24 of them were again evaluated 1 year later. Ten patients were weaned off parenteral nutrition and 15 were dependent on parenteral nutrition. Fifty-four healthy volunteers (28 women and 26 men) served as controls. Amino acid levels were determined on serum with high-performance liquid chromatography (HPLC) as well as on blood and serum with tandem mass spectrometry analysis. Five amino acids (citrulline, leucine, isoleucine, valine and tyrosine) were significantly lower in all SBS patients than in controls, whereas glutamine, measured only by HPLC, was significantly higher. Nevertheless, only serum citrulline measured with HPLC was significantly related to small bowel length. We conclude that HPLC remains the reference methodology to evaluate blood or serum amino acid levels in adult population with SBS.

Authors+Show Affiliations

Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli Federico II, Napoli, Italy. nad2005@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18997462

Citation

Santarpia, Lidia, et al. "Citrulline Blood Levels as Indicators of Residual Intestinal Absorption in Patients With Short Bowel Syndrome." Annals of Nutrition & Metabolism, vol. 53, no. 2, 2008, pp. 137-42.
Santarpia L, Catanzano F, Ruoppolo M, et al. Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome. Ann Nutr Metab. 2008;53(2):137-42.
Santarpia, L., Catanzano, F., Ruoppolo, M., Alfonsi, L., Vitale, D. F., Pecce, R., Pasanisi, F., Contaldo, F., & Salvatore, F. (2008). Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome. Annals of Nutrition & Metabolism, 53(2), 137-42. https://doi.org/10.1159/000170888
Santarpia L, et al. Citrulline Blood Levels as Indicators of Residual Intestinal Absorption in Patients With Short Bowel Syndrome. Ann Nutr Metab. 2008;53(2):137-42. PubMed PMID: 18997462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome. AU - Santarpia,Lidia, AU - Catanzano,Francesca, AU - Ruoppolo,Margherita, AU - Alfonsi,Lucia, AU - Vitale,Dino Franco, AU - Pecce,Rita, AU - Pasanisi,Fabrizio, AU - Contaldo,Franco, AU - Salvatore,Francesco, Y1 - 2008/11/10/ PY - 2007/10/15/received PY - 2008/07/03/accepted PY - 2008/11/11/pubmed PY - 2009/3/3/medline PY - 2008/11/11/entrez SP - 137 EP - 42 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 53 IS - 2 N2 - Plasma citrulline is known to be a marker of absorptive enterocyte mass in humans. We evaluated whether citrulline and other blood amino acids are indicators of residual small intestinal length and therefore potential predictors of dependence on parenteral nutrition in the long term. We studied 25 patients with short bowel syndrome (SBS) after at least 18 months since last digestive circuit modification; 24 of them were again evaluated 1 year later. Ten patients were weaned off parenteral nutrition and 15 were dependent on parenteral nutrition. Fifty-four healthy volunteers (28 women and 26 men) served as controls. Amino acid levels were determined on serum with high-performance liquid chromatography (HPLC) as well as on blood and serum with tandem mass spectrometry analysis. Five amino acids (citrulline, leucine, isoleucine, valine and tyrosine) were significantly lower in all SBS patients than in controls, whereas glutamine, measured only by HPLC, was significantly higher. Nevertheless, only serum citrulline measured with HPLC was significantly related to small bowel length. We conclude that HPLC remains the reference methodology to evaluate blood or serum amino acid levels in adult population with SBS. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18997462/Citrulline_blood_levels_as_indicators_of_residual_intestinal_absorption_in_patients_with_short_bowel_syndrome_ L2 - https://www.karger.com?DOI=10.1159/000170888 DB - PRIME DP - Unbound Medicine ER -